Zobrazeno 1 - 10
of 41
pro vyhledávání: ''
Autor:
Walter Berger, Bálint Szeder, Dona Greta Isai, Ildikó Kovács, Edina Bugyik, Zoltan Neufeld, Andras Czirok, Balazs Dome, Júlia Tárnoki-Zách, Elod Mehes, Balazs Hegedus, Sufi M. Thomas, Sándor Paku, Paul Stockhammer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Malignant pleural mesothelioma (MPM) has an overall poor prognosis and unsatisfactory treatment options. MPM nodules, protruding into the pleural cavity may have growth and spreading dynamics distinct that of other solid tumors. We demonstrate that m
Autor:
Nancy J. Sullivan, Juan I. Moliva, Adam S. Olia, Shuishu Wang, Baoshan Zhang, Emily Phung, Peter D. Kwong, Christina Yap, Anne P. Werner, Barney S. Graham, Cara W. Chao, Raffaello Verardi, Lingshu Wang, Guillaume Stewart-Jones, Kizzmekia S. Corbett, John R. Mascola, Geoffrey B. Hutchinson, Amarendra Pegu, Olubukola M. Abiona, Eun Sung Yang, Yaroslav Tsybovsky, Tongqing Zhou
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
bioRxiv
Scientific Reports
bioRxiv
Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses and have been playing an increasingly prominent role in structure-based vaccines. However, the development of such immunogens is often complicated by inefficien
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Gap junction (GJ) channels permit molecules, such as ions, metabolites and second messengers, to transfer between cells. Their function is critical for numerous cellular interactions. GJ channels are composed of Connexin (Cx) hexamers paired across e
Autor:
Gehre, Christian, Flechner, Marie, Kammerer, Sarah, Küpper, Jan-Heiner, Coleman, Charles Dominic, Püschel, Gerhard Paul, Uhlig, Katja, Duschl, Claus
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Most in vitro test systems for the assessment of toxicity are based on endpoint measurements and cannot contribute much to the establishment of mechanistic models, which are crucially important for further progress in this field. Hence, in recent yea
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Acidosis of the tumor microenvironment leads to cancer invasion, progression and resistance to therapies. We present a biophysical model that describes how tumor cells regulate intracellular and extracellular acidity while they grow in a microenviron
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
The function of steroid receptors in the cell depends on the chaperone machinery of Hsp90, as Hsp90 primes steroid receptors for hormone binding and transcriptional activation. Several conserved proteins are known to additionally participate in recep
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Tumor invasion within the interstitial space is critically regulated by the force balance between cell-extracellular matrix (ECM) and cell-cell interactions. Interstitial flows (IFs) are present in both healthy and diseased tissues. However, the role
Autor:
Houfang Long, Cong Liu, Dan Li, Yunpeng Sun, Chunyu Zhao, Xueming Li, Yaowang Li, Feng Luo, Kun Zhao, Youqi Tao, Xiao-Dong Su, Zhenying Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-65287-4
info:cnr-pdr/source/autori:Fiore, Michele and Picco, Cristiana and Moran, Oscar/titolo:Correctors modify the bicarbonate permeability of F508del-CFTR/doi:10.1038%2Fs41598-020-65287-4/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-65287-4
info:cnr-pdr/source/autori:Fiore, Michele and Picco, Cristiana and Moran, Oscar/titolo:Correctors modify the bicarbonate permeability of F508del-CFTR/doi:10.1038%2Fs41598-020-65287-4/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports
One of the most common mutations in Cystic Fibrosis (CF) patients is the deletion of the amino acid phenylalanine at position 508. This mutation causes both the protein trafficking defect and an early degradation. Over time, small molecules, called c
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted