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Autor:
Jiao Li, Shaoheng Li, Liping Liu, Hee-Do Hong, Qinggao Zhang, Yong Yang, Shuo Yuan, Xiaoyu Tan, Yuying Cao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Aging is an irreversible process. This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rosen, in aging rats. Rats were subcutaneously injected with 400 mg/kg of d-galactose daily, a
Autor:
Hu, Yuanyuan, Cronan, John E.
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Pimelic acid, a seven carbon α,ω-dicarboxylic acid (heptanedioic acid), is known to provide seven of the ten biotin carbon atoms including all those of the valeryl side chain. Distinct pimelate synthesis pathways were recently elucidated in Escheri
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Hippocampal atrophy and cognitive decline are common sequelae of many neurodegenerative disorders, including stroke. To determine whether cognitive decline can be ameliorated by exercise-induced neurogenesis, C57BL/6 mice in which a unilateral hippoc
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Acute cerebral ischaemia may lead to serious consequences, including brain injury caused by uncontrolled reperfusion, which occurs when circulation is re-established. The long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) pla
Autor:
Keiko Hikino, Satoshi Nakagawa, Kentaro Ide, Chikashi Terao, Taisei Mushiroda, Masaru Koido, Nao Nishimura
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
We aimed to identify attributing factors to the interindividual variabilities of the infusion rates in unfractionated heparin therapy. We included patients who required unfractionated heparin therapy to achieve the target APTT after cardiac surgery b
Autor:
José María Zapico, Gonzalo Herradón, Esther Gramage, M. Pilar Ramos-Alvarez, Marta Vicente-Rodríguez, Milagros Galán-Llario, María Uribarri, Rosalía Fernández-Calle, Marcel Ferrer-Alcón, Begoña Zapatería, Beatriz de Pascual-Teresa, Ana Ramos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels i
Autor:
Stefan Vasile, Fenfei Leng, Sabrina Battista, Juliano Freitas, Jeremy W. Chambers, Alyssa Garabedian, Federica D'Alessio, Miriam Romano, Prem P. Chapagain, Linjia Su, Francisco Fernandez-Lima, Alfredo Fusco, Layton H. Smith, Nadezda Bryan, Fabiana Falanga, Lidia Kos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and
Autor:
Qinfeng Mu, Jun Zhang, Ying Zhou, Haixiang Xue, Tongbing Chen, Jisheng Liu, Miaomei Yu, Guanghua Luo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this stu
Autor:
Gustavo Monasterio, Rolando Vernal, Maria Elena Vega, Mario Galindo, Carla Alvarez, Rawan Almarhoumi, Carolina Rojas, Alpdogan Kantarci, Salwa Suliman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
The alveolar bone resorption is a distinctive feature of periodontitis progression and determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive mechanisms and tissue repairing functions, which are critical to support pe
Autor:
Sinead M. Waters, Mark McGee, Jennifer B. McClure, Dayle Johnston, Bernadette Earley, C.G. Todd, Carla Surlis, Matthew C. McClure, Robert Mukiibi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Johnston, D, Mukiibi, R, Waters, S M, McGee, M, Surlis, C, McClure, J C, McClure, M C, Todd, C G & Earley, B 2020, ' Genome wide association study of passive immunity and disease traits in beef-suckler and dairy calves on Irish farms ', Scientific Reports, vol. 10, no. 1, 18998 . https://doi.org/10.1038/s41598-020-75870-4
Scientific Reports
Johnston, D, Mukiibi, R, Waters, S M, McGee, M, Surlis, C, McClure, J C, McClure, M C, Todd, C G & Earley, B 2020, ' Genome wide association study of passive immunity and disease traits in beef-suckler and dairy calves on Irish farms ', Scientific Reports, vol. 10, no. 1, 18998 . https://doi.org/10.1038/s41598-020-75870-4
Scientific Reports
Calves with lower concentrations of immunoglobulin G (IgG) in their blood, have a greater risk of developing diseases. There is a lack of knowledge on genetic markers known to be associated with immunological variability or disease resistance. Theref