Zobrazeno 1 - 10
of 13
pro vyhledávání: ''
Autor:
Nancy J. Sullivan, Juan I. Moliva, Adam S. Olia, Shuishu Wang, Baoshan Zhang, Emily Phung, Peter D. Kwong, Christina Yap, Anne P. Werner, Barney S. Graham, Cara W. Chao, Raffaello Verardi, Lingshu Wang, Guillaume Stewart-Jones, Kizzmekia S. Corbett, John R. Mascola, Geoffrey B. Hutchinson, Amarendra Pegu, Olubukola M. Abiona, Eun Sung Yang, Yaroslav Tsybovsky, Tongqing Zhou
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
bioRxiv
Scientific Reports
bioRxiv
Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses and have been playing an increasingly prominent role in structure-based vaccines. However, the development of such immunogens is often complicated by inefficien
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
The function of steroid receptors in the cell depends on the chaperone machinery of Hsp90, as Hsp90 primes steroid receptors for hormone binding and transcriptional activation. Several conserved proteins are known to additionally participate in recep
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted
Autor:
Fayaj A. Mulani, Hariharakrishnan Chidambaram, Nalini Vijay Gorantla, Hirekodathakallu V. Thulasiram, Tushar Dubey, Subashchandrabose Chinnathambi, Rashmi Das
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
The Alzheimer’s disease pathology is associated with accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. The formation of initial nucleus triggers conformational changes in Tau and leads to its deposition. Hence,
Autor:
Vlad-Stefan Raducanu, Muhammad Tehseen, Nekane Merino, Afnan Shirbini, Francisco J. Blanco, Alfredo De Biasio, Fahad Rashid, Manal S. Zaher, Claudia Lancey, Samir M. Hamdan, Timothy J. Ragan, Christos G. Savva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-res
Autor:
Ira G. Schulman, Daniel Hovdal, Emma Evertsson, Emma Bratt, Anna Y. Belorusova, Eva-Lotte Lindstedt, Peter Åkerblad, Jenny Sandmark, Ingela Maxvall
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
'Communications Biology ', vol: 2, pages: 431-1-431-13 (2019)
Communications Biology
'Communications Biology ', vol: 2, pages: 431-1-431-13 (2019)
Liver X receptors (LXRs) are attractive drug targets for cardiovascular disease treatment due to their role in regulating cholesterol homeostasis and immunity. The anti-atherogenic properties of LXRs have prompted development of synthetic ligands, bu
Autor:
Emily C. Dykhuizen, Tyler M. Weaver, Catherine A. Musselman, Katelyn E. Connelly, Katayoun Varzavand, Jiachen Liu, Chris Coble
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
SANT domains are found in a number of chromatin regulators. They contain approximately 50 amino acids and have high similarity to the DNA binding domain of Myb related proteins. Though some SANT domains associate with DNA others have been found to bi
Autor:
Pingyong Xu, Fa Zhang, Fudong Xue, Fan Xu, Renmin Han, Mingshu Zhang, Jennifer Lippincott-Schwartz, Wenting He, Zhiyong Liu
Publikováno v:
Cell Research
Autor:
Nadya I. Tarasova, Urszula Nowicka, Marzena A. Dyba, Shigeo Murata, Fen Liu, Jun Hamazaki, Vinidhra Sridharan, Terrence R. Burke, David Hymel, Leah Randles, Sergey G. Tarasov, Xiuxiu Lu, Kylie J. Walters, Xue Zhi Zhao
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Proteasome–ubiquitin receptor hRpn13/Adrm1 binds and activates deubiquitinating enzyme Uch37/UCHL5 and is targeted by bis-benzylidine piperidone RA190, which restricts cancer growth in mice xenografts. Here, we solve the structure of hRpn13 with a
Publikováno v:
Scientific Reports
Photodynamic therapy (PDT) is a promising method for neoplastic and nonneoplastic diseases. In this study, we utilized sinoporphyrin sodium (DVDMS) as a sensitizer combined with light to investigate its cytotoxic effect on different cell lines. For t