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Autor:
Yujin Shi, Wensheng Wei, Tao Jiao, Tian Zheng, Ruiyi Ma, Lili Ren, Qi Jiang, Zichun Xiang, Zhixun Dou, Jian Rao, Zhuo Zhou, Xinyi Zhang, Zhengfan Jiang, Jianwei Wang, Wenjing Wang, Xia Xiao, Tao Deng, Xiaojing Dong, Xiaobo Lei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the host immune system senses and responds to SARS-CoV-2 infection remain to be determi
Autor:
Sara Hultberg, Kurt Wahlstedt, Margareta Reis, Jörgen Rosén, Kristoffer N.T. Månsson, Olof R. Hjorth, Malin Gingnell, Vanda Faria, Andreas Frick, Johanna M. Hoppe, Mark Lubberink, Mats Fredrikson, Iman Alaie, Tomas Furmark, Gunnar Antoni, My Jonasson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with serotonin transporte
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that
Autor:
Jan Rybniker, Hannah S. Eisfeld, Melanie Fritsch, Manolis Pasparakis, Sebastian J. Theobald, Sandra Winter, Jessica Gräb, Maximilian Koch, Hamid Kashkar, Christoph Hölscher, Isabelle Suárez
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery
Cell Death Discovery
Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of p
Autor:
Qiudan Chen, Xiaotong Chen, Zhong Wu, Guanglei Song, Shihao Zhuang, Weifeng Wang, Shuying Chen, Yuan Lv, Yong Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug resistance of glioblastoma (GBM) cells. In this study, we analyzed the role and potential mechanism of l
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various fields including inflammation. The specific mechanism of metformin’s effect on immune cells remains unclear. Herein, it is verified that LPS-induced macroph
Autor:
Huey-Jiun Ko, Chung-Hwan Chen, Chihuei Wang, Po-Hsu Chou, Cheng-Jung Ho, Tzu-Shao Liao, Xiang-Ren Zheng, Li-Ting Wang, Ru-Wei Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred
Autor:
NiJiati AiErken, Pian Liu, Ying Lin, Huijuan Zeng, Nan Shao, Shenming Wang, Runyi Ye, Xiaying Kuang
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-10 (2021)
Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are a new class of SUMO E3 ligases, which
Autor:
Peijing Zhang, Shan Huang, Yiming Zeng, Manyu Zhao, Hong Luo, Zhicheng Zhou, Yuan Quan, Mengru Ma, Li Su, Lixu Tang, Jongchan Kim
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, h
Autor:
Dongxia Zhang, Yanling Lv, Jiongyu Hu, Yanhai Feng, Qiong Zhang, Yuesheng Huang, Yao Huang, Junhui Zhang, Lingfei Li, Jiezhi Jia
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Phosphorylation of MAP4 (p-MAP4) causes cardiac remodeling, with the cardiac microvascular endothelium being considered a vital mediator of this process. In the current study, we investigated the mechanism underlying p-MAP4 influences on cardiac micr