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Autor:
Sara Hultberg, Kurt Wahlstedt, Margareta Reis, Jörgen Rosén, Kristoffer N.T. Månsson, Olof R. Hjorth, Malin Gingnell, Vanda Faria, Andreas Frick, Johanna M. Hoppe, Mark Lubberink, Mats Fredrikson, Iman Alaie, Tomas Furmark, Gunnar Antoni, My Jonasson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with serotonin transporte
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Cell Death & Disease
Cell Death & Disease
The decrease of neurotransmitter dopamine (DA) levels in the intestine is closely related to the development of inflammatory bowel disease (IBD). However, the functional relevance and underlying mechanistic basis of the effects of DA signaling on IBD
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat
Autor:
Wael N. Hozzein, Hany R. Hashem, Ayat Tawfik, Abdelazeem M. Algammal, Reham M. El-Tarabili, Waleed M. El Kazzaz, Helal F Hetta, Gaber El-Saber Batiha
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
This study aimed to evaluate the prevalence, multidrug-resistance traits, PCR-detection of virulence, and antibiotic-resistance genes of E. coli isolated from secondary infections following FMD-outbreak in cattle. A total of 160 random samples were g
Autor:
Stefan Vasile, Fenfei Leng, Sabrina Battista, Juliano Freitas, Jeremy W. Chambers, Alyssa Garabedian, Federica D'Alessio, Miriam Romano, Prem P. Chapagain, Linjia Su, Francisco Fernandez-Lima, Alfredo Fusco, Layton H. Smith, Nadezda Bryan, Fabiana Falanga, Lidia Kos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The rise of antibiotic resistance in many bacterial pathogens has been driven by the spread of a few successful strains, suggesting that some bacteria are genetically pre-disposed to evolving resistance. Here, we test this hypothesis by challenging a
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Medaka (Oryzias latipes) is a teleost fish with an XX/XY sex determination system, similar to that of mammals. However, under high temperature conditions, XX medaka is masculinised by elevation of cortisol, the major teleost glucocorticoid. In this s
Autor:
László Makrai, Dóra Tőzsér, Adrienn Gréta Tóth, István Csabai, Á Patai, Norbert Solymosi, Gergely Maróti, Eszter Krikó, Géza Szita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
The increasing prevalence of antimicrobial resistance (AMR) is a significant threat to global health. More and more multi-drug-resistant bacterial strains cause life-threatening infections and the death of thousands of people each year. Beyond diseas
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
Recent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resist
Autor:
Siyun Cheng, Tan Zhongming, Chen Dong, Huimin Qian, Dazhi Jin, Jinfeng Bao, Bing Gu, Changjun Bao, Jie Hong, Guoye Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Objective: To investigate the prevalence of Salmonella Typhi and Paratyphi resistance to quinolones and characterize the underlying mechanism in Jiangsu Province of China. Methods: Antimicrobial susceptibility testing was performed using Kirby-Bauer