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Publikováno v:
Scientific Reports
Inflammatory bowel disease confers an increased risk of developing colitis-associated colon cancer (CAC). During the active colitis or developing tumor stage, commensal bacteria show dynamic translocation. However, whether alteration of the bacterial
Autor:
Victoria Hedrick, Mostafa F. N. Abushahba, Tiago J. P. Sobreira, Mohamed N. Seleem, Lake N. Paul, Shankar Thangamani, Haroon Mohammad
Publikováno v:
Scientific Reports
Traditional methods employed to discover new antibiotics are both a time-consuming and financially-taxing venture. This has led researchers to mine existing libraries of clinical molecules in order to repurpose old drugs for new applications (as anti
Autor:
Hirobumi Fuchigami, Masahiro Yasunaga, Toshifumi Obonai, Fumiaki Furuya, Yasuhiro Matsumura, Naoyuki Kozuka
Publikováno v:
Scientific Reports
The diagnosis of early and aggressive types of cancer is important for providing effective cancer therapy. Cancer-induced fibrin clots exist only within lesions. Previously, we developed a monoclonal antibody (clone 102-10) that recognizes insoluble
Autor:
Mi-Ae Kim, JungIn Lee, Jae Sam Hwang, Wonhwa Lee, Roshan R. Kulkarni, MinKyun Na, Jong-Sup Bae
Publikováno v:
Scientific Reports
SCIENTIFIC REPORTS(6)
SCIENTIFIC REPORTS(6)
The aim of this study was to discover small-molecule anticoagulants from Scolopendra subspinipes mutilans (SSM). A new acylated polyamine (1) and a new sulfated quinoline alkaloid (2) were isolated from SSM. Treatment with the new alkaloids 1, 2, and
Autor:
Joya Chandra, Christa A. Manton, Blake Johnson, Cavan P. Bailey, Melissa M. Singh, Lisa Bouchier-Hayes
Publikováno v:
Scientific Reports
New therapies for glioblastoma (GBM) are needed, as five-year survival is in vivo properties of MRZ in GBM. The activation kinetics of initiator caspases 2, 8 and 9 were assessed using chemical and knockdown strategies to determine their contribution
Autor:
Louxin Zhang, Kwi Shan Seah, Audrey Yuen, Seok Hwee Koo, Thi Thuy Trang Nguyen, Brian W. Dymock, Edmund J.D. Lee, Eugene Guorong Yang, Shermaine Yu Wen Pang, Kim Kiat Lim, Jie Yin Yee, Wee Han Ang, Ee Sin Chen, Jacqueline Chua
Publikováno v:
Scientific Reports
Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting the most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we describe a targeted approach th
Autor:
Yanling Zhao, Wen-Ming Cao, Yifan Yang, Xin Xu, Wenjing Sun, Sophia L. Huang, Yan Shi, Hao Wang, Hong Zhang, Yang Yu, Eugene S. Kim, Yo Akiyama, Long Wang, Huiyuan Zhang, Zhenghu Chen, Jianhua Yang, Jonathan C. Pang, Fengmin Lu, Jodi A. Muscal, Yongfeng Wang, Shan Guan
Publikováno v:
Scientific Reports
ALK receptor tyrosine kinase has been shown to be a therapeutic target in neuroblastoma. Germline ALK activating mutations are responsible for the majority of hereditary neuroblastoma and somatic ALK activating mutations are also frequently observed
Autor:
Hadley Mouhsine, Caroline Bouchez, Rojo Ratsimandresy, Jean-François Zagury, Lucille Desallais, Françoise Quintin-Colonna, Matthieu Montes, Gabriel Moreau, Hervé Do
Publikováno v:
Scientific Reports
Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the dr
Autor:
Alex J. O'Neill, Anastasia Zhuravleva, Gary S. Thompson, Arnout P. Kalverda, Jennifer Tomlinson
Publikováno v:
Scientific Reports
Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural charac
Autor:
Markus Arnoldini, Philip Kollmannsberger, Stefan S. Weber, Martin Ackermann, Viola Vogel, Stefanie Meier, Vahid Hosseini, Ima Avalos Vizcarra
Publikováno v:
Scientific Reports
Scientific Reports, 6
SCIENTIFIC REPORTS
Scientific Reports, 6
SCIENTIFIC REPORTS
To survive antibiotics, bacteria use two different strategies: counteracting antibiotic effects by expression of resistance genes or evading their effects e.g. by persisting inside host cells. Since bacterial adhesins provide access to the shielded,