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Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that
Autor:
Qiudan Chen, Xiaotong Chen, Zhong Wu, Guanglei Song, Shihao Zhuang, Weifeng Wang, Shuying Chen, Yuan Lv, Yong Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug resistance of glioblastoma (GBM) cells. In this study, we analyzed the role and potential mechanism of l
Autor:
Huey-Jiun Ko, Chung-Hwan Chen, Chihuei Wang, Po-Hsu Chou, Cheng-Jung Ho, Tzu-Shao Liao, Xiang-Ren Zheng, Li-Ting Wang, Ru-Wei Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred
Autor:
NiJiati AiErken, Pian Liu, Ying Lin, Huijuan Zeng, Nan Shao, Shenming Wang, Runyi Ye, Xiaying Kuang
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-10 (2021)
Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are a new class of SUMO E3 ligases, which
Autor:
Peijing Zhang, Shan Huang, Yiming Zeng, Manyu Zhao, Hong Luo, Zhicheng Zhou, Yuan Quan, Mengru Ma, Li Su, Lixu Tang, Jongchan Kim
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, h
Autor:
Peiquan Zhang, Jinbao Liu, Leyi Yao, Ding Yan, Q. Ping Dou, Qingtian Huang, Xin Chen, Xiaofen Li, Qianqian Yang, Shuhui Lin, Wenshuang Sun
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously rep
Autor:
Song Wu, Anli Yang, Cheng Peng, Shunling Ou, Xing Li, Zhongying Huang, Lewei Zhu, Peng Liu, Fu Peng, Yanan Kong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Melatonin has been reported to have tumor-suppressive effects via comprehensive molecular mechanisms, and long non-coding RNAs (lncRNAs) may participate in this process. However, the mechanism by which melatonin affects the function of lncRNAs in tri
Autor:
Weijun Liu, Weiyang Cai, Ying-Li Wu, Wenfu Tan, Jun Yang, Yu Zou, Yuan Liu, Qingqing Ding, Wenjing Huang, Yu Zhang, Juan Wang, Jing Gao, Hu Zhou, Zhang Yanjie, Pei hao Yin, Yanyan Qiu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal
Autor:
Xiaoyu Xia, Dongya Zhang, Yuchen Pan, Guoping Shi, Jingman Li, Yujun Xu, Dan Li, Li Lu, Yayi Hou, Huan Dou
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. Myeloid-derived suppressor cells (MDSCs) have been found to be involved in the regulation of SLE development. However, little is known about the association between MDSC sub
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Chemotherapy remains the primary treatment of advanced solid cancer, including lung cancer. However, as first-line treatment, cisplatin-based therapy is restricted by the frequent development of drug resistance. Increasing data showed that the progra