Zobrazeno 1 - 10
of 729
pro vyhledávání: ''
Autor:
Yiping Qu, Nongyue He, Jun Pu, Chenxing Da, Jian Yang, Peng Hou, Bingyin Shi, Yongxing Wu, Jing Wei, Zhe Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
HACE1, an E3 ubiquitin-protein ligase, is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of cancer. However, its role in glioma remains elusive. Here, we observed increased expression of HACE1 in gliom
Autor:
Yuyao Peng, Yi Li, Huan Yang, Cheng-Kai Yan, Liqun Xu, Qi Yang, Bo Xiao, Wanlin Jin, Zhaohui Luo
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-18 (2021)
Cell Discovery
Cell Discovery
Myasthenia gravis (MG) is a rare autoimmune disease. Although the impact of immune cell disorder in MG has been extensively studied, little is known about the transcriptomes of individual cells. Here, we assessed the transcriptional profiles of 39,24
Autor:
Fei Ye, Xi Lin, Ao Wen, Jiong Li, Xindan Zhang, Zimin Chen, Guobo Shen, Wei Wang, Xiawei Wei, Yushan Dai, Lingling Wang, Zhenling Wang, Hua Chen, Li Yang, Jing Yang, Sheng Lin, Honglu Sun, Fanli Yang, Jingyun Yang, Yu Cao, Guangwen Lu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 can therefore function as a decoy. Here we show that mutations of S19W, T27W, and N3
Autor:
Yun Ling, Qiming Liang, Yi Zhao, Yang-dian Lai, Lei Shen, Bing Su, Lingjie Luo, Wenhua Liang, Ying Wang, Yang Liu, Lei Chen, Xinrong Guo, Wang Xin, Shuye Zhang, Gang Xu, Bin Li, Jianfeng Pang, Yingying Chen, Michal Baniyash, Zheng Zhang, Hongzhou Lu, Feng Wang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-17 (2021)
Cell Discovery
Cell Discovery
SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection. Here, we present both single-cell TCR-se
Autor:
Guan Yang, Yao Zhang, Jian-Feng Liu, Rong-Rong Zhang, Ruiting Li, Cheng-Feng Qin, Qing Ye, Hui-Ming Zhu, Xiao Yang, Qi He, Qi Chen, Shu-Jia Wu, Yong-Qiang Deng, Ping Xu, Xiaofeng Li, Tao Zhang, Jia-Hui Shi, Jia Zhou, Hong-Ying Qiu
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Discovery
Cell Discovery
SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mechanism by which SARS-CoV-2 infection leads
Autor:
Xueliang Zhu, Liang Chen, Honghua Sun, Meiting Yue, Xinhua Feng, Zhen Qin, Xiumin Yan, Hongbin Ji, Xinwen Pan
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Discovery
Cell Discovery
EML4–ALK fusion, observed in about 3%–7% of human lung adenocarcinoma, is one of the most important oncogenic drivers in initiating lung tumorigenesis. However, it still remains largely unknown about how EML4–ALK fusion exactly fires downstream
Autor:
Xiangxi Wang, Lei Wang, De-Ju Xia, Hai Hou, Si-Hong Xu, Lunbiao Cui, Ling Zhu, Kang Wang, Da-Wei Shi, Rui Feng, Li Zhang, Zheng Binyang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-4 (2021)
Cell Discovery
Cell Discovery
Autor:
Xiaoqun Wang, Changjiang Zhang, Yantao Ma, Xiaomin Du, Lipeng Wang, Cheng Li, Hongkui Deng, Mengdi Wang, Shicheng Sun, Zhuo Huang, Jun Xu, Zhen Chai, Xueqin Jin, Handan Xie, Yawen Han, Longteng Wang, Qianqian Zhang, Xiang Li
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Discovery
Cell Discovery
In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue could potentially be compensated by converting nearby cells in situ through in vivo reprogramming. Small molecule-induced cell reprogramming offers a temporally
Autor:
Ping Lu, Xiaofeng Wen, Meifen Zhang, Ming Jin, Chan Zhao, Yanli Zou, Tingting Chen, Yu Liu, Richard W J Lee, Xinhua Huang, Li Miao, Ge Xiaofei, Weiyi Lai, Yinyin Li, Xiao Hu, Yuhua Deng, Jing Jing Li, Weirong Chen, Xiuli Deng, Haotian Lin, Chi-Chao Chan, Qinfen Zhang, Xiaofeng Lin, Chunmei Li, Yali Qin, Xiaomin Zhang, Dongni Wang, Xiaorong Li, Xun Wang, Xifang Li, Lin Lu, Guanghua Peng, Yan Li, Lai Wei, Yizhi Liu, Juanran Liang, Wei Chen, Liu Yang, Shixin Guo, Qiaoxing Liang, Bin Zou, Xiulan Zhang, Fuhua Yang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Discovery
Cell Discovery
The current dogma in ophthalmology and vision research presumes the intraocular environment to be sterile. However, recent evidence of intestinal bacterial translocation into the bloodstream and many other internal organs including the eyes, found in
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-3 (2021)
Human Genome Variation
Human Genome Variation
An infant with 46,XY karyotype, and unambiguous female phenotype was found to have testes in the inguinal regions. Capillary sequencing of the androgen receptor (AR) gene identified a hemizygous de novo mutation (NM_000044.6:c.1621G > T) in exon 2 re