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Autor:
Elena Kostromina, Christoffer Nord, Tomas Alanentalo, Federico Morini, Per Olof Berggren, Yan Xiong, Erwin Ilegems, Jürgen Mayer, Pim P van Krieken, James Sharpe, Ulf Ahlgren, Teresa Pereira, Maria Eriksson, Jorge L. Ruas, Max Hahn
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Mouse models of Streptozotocin (STZ) induced diabetes represent the most widely used preclinical diabetes research systems. We applied state of the art optical imaging schemes, spanning from single islet resolution to the whole organ, providing a fir
Autor:
Yuxi Li, Jung-Chien Cheng, Sijia Wang, Zhen Wang, Xiaoyu Han, Yiran Li, Yingpu Sun, Yang Yan, Lanlan Fang, Ze Wu, Qiongqiong Jia
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1341-1350 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHS
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Fifteen adult Soay rams were employed in this study to investigate the effect of melatonin on the scrotal skin using histological, histochemical, and morphometrical analysis. The results revealed that the melatonin treated group showed a significant
Autor:
Jeanie B. Tryggestad, April M. Teague, Shaoning Jiang, Mary Ellen Jensen, Steven D. Chernausek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain
Autor:
Jorge F. Gómez-Cerezo, Tania Romacho, Susana Vallejo, Óscar Lorenzo, Inés Valencia, Álvaro San Hipólito-Luengo, Mariella Ramos-González, Carlos F. Sánchez-Ferrer, Miguel López-Esteban, Alejandra Romero, Concepción Peiró, Pablo Cannata
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Visfatin/extracellular-nicotinamide-phosphoribosyltranferase-(eNampt) is a multifaceted adipokine enhanced in type-2-diabetes and obesity. Visfatin/eNampt cause in vitro endothelial dysfunction and vascular inflammation, although whether the same eff
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Oxidative stress has been linked to a number of chronic diseases, and this has aroused interest in the identification of clinical biomarkers that can accurately assess its severity. We used liquid chromatography-high resolution mass spectrometry (LC-
Autor:
Shuyu Piao, Seonhee Kim, Byeong Hwa Jeon, Su-jeong Choi, Ikjun Lee, Cuk-Seong Kim, Harsha Nagar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Downregulation of CR6 interacting factor 1 (CRIF1) has been reported to induce mitochondrial dysfunction, resulting in reduced activity of endothelial nitric oxide synthase (eNOS) and NO production in endothelial cells. Tetrahydrobiopterin (BH4) is a
Autor:
Carla Bettoni, Petra Seebeck, Arezoo Daryadel, Carsten A. Wagner, Udo Schnitzbauer, Max Gassmann, Luciano Natale
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Fibroblast Growth Factor 23 (FGF23) is a phosphaturic factor causing increased renal phosphate excretion as well as suppression of 1,25 (OH)2-vitamin D3. Highly elevated FGF23 can promote development of rickets and osteomalacia. We and others previou
Autor:
Qing Gao, Luke Norton, Yuejuan Qin, Chris E. Shannon, Zi Ming Cheng, Muhammad A. Abdul-Ghani, Balakuntalam S. Kasinath, Anqi Luo, Nathan Harper, Xingyu Zhang, Marcel Fourcaudot, Patricia L. M. Dahia, Ricardo C.T. Aguiar, Subramanya Srikantan, Sifan Tao, Robert L. Reddick, Stephen Harrison, Sunil K. Ahuja, Zhi Li, Glaiza Mae Sande-Docor, Yilun Deng, Lily Q. Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Understanding the molecular components of insulin signaling is relevant to effectively manage insulin resistance. We investigated the phenotype of the TMEM127 tumor suppressor gene deficiency in vivo. Whole-body Tmem127 knockout mice have decreased a
Autor:
Lisanne L. Blauw, Yanan Wang, Huub J. van Eyk, Renée de Mutsert, Johannes W. A. Smit, Patrick C.N. Rensen, Ingrid M. Jazet, Ko Willems van Dijk, Hildo J. Lamb, Maurice B. Bizino
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, 9. NATURE PUBLISHING GROUP
Scientific Reports, 9
Scientific Reports
Scientific Reports, 9. NATURE PUBLISHING GROUP
Scientific Reports, 9
Scientific Reports
Cholesteryl ester transfer protein (CETP) is mainly expressed by Kupffer cells in the liver. A reduction of hepatic triglyceride content (HTGC) by pioglitazone or caloric restriction is accompanied by a decrease in circulating CETP. Since GLP-1 analo