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Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that
Autor:
Peijing Zhang, Shan Huang, Yiming Zeng, Manyu Zhao, Hong Luo, Zhicheng Zhou, Yuan Quan, Mengru Ma, Li Su, Lixu Tang, Jongchan Kim
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, h
Autor:
Song Wu, Anli Yang, Cheng Peng, Shunling Ou, Xing Li, Zhongying Huang, Lewei Zhu, Peng Liu, Fu Peng, Yanan Kong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Melatonin has been reported to have tumor-suppressive effects via comprehensive molecular mechanisms, and long non-coding RNAs (lncRNAs) may participate in this process. However, the mechanism by which melatonin affects the function of lncRNAs in tri
Autor:
Weijun Liu, Weiyang Cai, Ying-Li Wu, Wenfu Tan, Jun Yang, Yu Zou, Yuan Liu, Qingqing Ding, Wenjing Huang, Yu Zhang, Juan Wang, Jing Gao, Hu Zhou, Zhang Yanjie, Pei hao Yin, Yanyan Qiu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal
Autor:
Jiarui Liu, Shuai Ren, Yang Han, Xin Wang, Xiangxiang Zhou, Shunfeng Hu, Juan Yang, Yi Zhao, Yiqing Cai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chem
Autor:
Ke Chen, Xuemei Lu, Xian-Ning Zhang, Shufen Zhang, Xiao-Rui Luan, Wei Chen, Liqiang Hu, Jiayan Mao, J. Zhang, Xiaoxiao Zheng, Yuexiao Tang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Gastrointestinal stromal tumors (GISTs) are common neoplasms of the gastrointestinal tract that can be treated successfully using C-kit target therapy and surgery; however, imatinib chemoresistance is a major barrier to success in therapy. The presen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases. However, the role of pyroptosis in chemothe
Autor:
Nianzhao Zhang, Shuo Zhao, Cheng Liu, Jikai Liu, Shuo Pang, Yidong Fan, Luchao Li, Zhengfang Liu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Receptor tyrosine kinase (RTK) inhibitors, such as sunitinib and sorafenib, remain the first-line drugs for the treatment of mRCC. Acquired drug resistance and metastasis are the main causes of treatment failure. However, in the case of metastasis Re
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repai
Autor:
Bin Liao, Nan Wu, Pan Wang, Qian Yan, Sheng Gong, Yangmin Deng, Liangqi Wu, Jinyu Pan, Shuanglong Xiong, Dewei Zou, Junwei Wang, Lu Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
Hypoxia-inducible factor 1α (HIF1α) promotes the malignant progression of glioblastoma under hypoxic conditions, leading to a poor prognosis for patients with glioblastoma; however, none of the therapies targeting HIF1α in glioblastoma have succes