Zobrazeno 51 - 60
of 309
pro vyhledávání: ''
Autor:
Taro Yamashita, Takayoshi Shirasaki, Tetsuro Suzuki, Masao Honda, Ryougo Shimizu, Katsuji Yoshioka, Tokiharu Sato, Saki Nakasyo, Tetsuro Shimakami, Kouki Nio, Natsumi Shirasaki, Kazuhisa Murai, Shuichi Kaneko, Yoshio Sakai, Hikari Okada
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling and hepatit
Autor:
Zheng Ruan, Zhu Chen, Wenda Xi, Lie Ma, Kongkai Zhu, Cheng Luo, Ru Zhang, Jian-Hua Mao, Xiaodong Xi, Yan Shen, Sai-Juan Chen
Publikováno v:
Cell Death and Disease, Vol 9, Iss 10, Pp 1-15 (2018)
Non-small cell lung cancer (NSCLC) is characterized by hyperexpression and/or gain-of-function mutations of the epidermal growth factor receptor (EGFR), resulting in an elevated overall kinase activity. Gefitinib is remarkably effective in patients w
Autor:
Katarzyna Poleszak, Bartosz Wojtas, Dominika Grzeganek, Maria Pasierbinska, Kamil Wojnicki, Aleksandra Ellert-Miklaszewska, Bozena Kaminska, Malgorzata Sielska, Piotr Przanowski, Min-Chi Ku, Helmut Kettenmann
Publikováno v:
British Journal of Cancer
Background Malignant tumours release factors, which attract myeloid cells and induce their polarisation to pro-invasive, immunosuppressive phenotypes. Brain-resident microglia and peripheral macrophages accumulate in the tumour microenvironment of gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628b5739312947a90a1310a84b8e8a44
http://edoc.mdc-berlin.de/18918/7/18918suppl.pdf
http://edoc.mdc-berlin.de/18918/7/18918suppl.pdf
Autor:
Tatjana Walther, Lena Wagner, Małgorzata Oleś, Benedikt Brors, Wolfgang Huber, Thorsten Zenz, Jennifer Hüllein, Leopold Sellner, Roman Vladimirovich Kurilov, Marina Lukas, Katarzyna Tomska, Kwang Seok Lee
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Burkitt lymphoma (BL) is a highly aggressive B-cell lymphoma associated with MYC translocation. Here, we describe drug response profiling of 42 blood cancer cell lines including 17 BL to 32 drugs targeting key cancer pathways and provide a systematic
Autor:
Peng Li, Yihua Pang, Fei Lu, Jingru Zhang, Xin Dong, Chunyan Ji, Min Ji, Wei Li, Daoxin Ma, Jingjing Ye, Shaolei Zang
Publikováno v:
Cell Death and Disease, Vol 9, Iss 9, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Tyrosine kinase inhibitor treatment of chronic myeloid leukemia (CML) has demonstrated beneficial effects. However, resistance to tyrosine kinase inhibitors and disease relapse are still a challenge for CML therapy. In this study, we analyzed bone ma
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
Epidermal growth factor receptor (EGFR) was evaluated as a target antigen for cancer cell capture by microfluidic methods based on antigen-antibody association. A polymer CTC-chip microfluidic device was surface-functionalized with three different an
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Hepatitis E is the most common type of acute hepatitis prevalent worldwide. The open reading frame 3 protein of HEV (HEV ORF3) is proposed to create a favorable environment for viral replication and pathogenesis. However, the mechanisms by which HEV
Autor:
Karin Boucke, Jovan Pavlovic, Cornel Fraefel, Christian Münz, Michel Crameri, Urs F. Greber, Francesca D. Franzoso, Raphael Walker, Andrea Zbinden, Nicole Caduff, Fiona Steiner, Talissa Kucera, Michael Bauer, Cornelia Gujer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Cytokine
5th Annual Meeting of the International-Cytokine-and-Interferon-Society
5th Annual Meeting of the International-Cytokine-and-Interferon-Society, Oct 2017, Kanazawa, Japan. pp.1
Nature Communications
Cytokine
5th Annual Meeting of the International-Cytokine-and-Interferon-Society
5th Annual Meeting of the International-Cytokine-and-Interferon-Society, Oct 2017, Kanazawa, Japan. pp.1
Nature Communications
The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, al
Autor:
Natalia D. Marchenko, Lucas Garcia, Alisha R. Yallowitz, Evguenia M. Alexandrova, Amr M. Ghaleb
Publikováno v:
Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Despite success of ERBB2-targeted therapies such as lapatinib, resistance remains a major clinical concern. Multiple compensatory receptor tyrosine kinase (RTK) pathways are known to contribute to lapatinib resistance. The heterogeneity of these adap
Autor:
Cori Ballard, Xiuhua Li, Yusheng Qian, Suzette D. Laing, K.C. Biju, Zhixu He, Guo Ge, Senlin Li, Eliezer Masliah, Cang Chen, Jingwei Liu, Robert A. Clark, Jason C. O'Connor
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent tested in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF is restricted by the blood-brain barrier (BBB). Using total