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Autor:
Ramesh K. Ganju, Sanjay Varikuti, Manish Charan, Nabanita Chatterjee, Swati Misri, Abhay R. Satoskar, Kirti Kaul, Dinesh K. Ahirwar, Sanjay Mishra, Subhadip Das
Publikováno v:
Cell Death and Disease, Vol 11, Iss 9, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype of highly aggressive breast cancer with worse prognosis and poor survival rate. Macrophage migration inhibitory factor (MIF) is a pleiot
Autor:
Yijian Li, Xiangfeng Liu, Guangdi Li, Huiling Li, Jian Pan, Bohao Liu, Yunchang Yuan, Xiaozhou Li, Peilin Zheng, Xudong Xiang, Xiangping Chai, Zhengyu Peng, Zhibiao He, Feng Liu, Hongliang Zhang, Dongshan Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation of proximal tubular DsbA-L for renal tubuloint
Autor:
Wei Xia, Xue Yin, Xue-fei Zhu, Bingyu Zhang, Weiming Liu, Peirong Lu, Chi Ren, Lei Chen, Gaoqin Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the macular area. Although close attention has been paid to AMD, and anti-vascular endothelial growth factor (V
Publikováno v:
Cell Death and Disease, Vol 11, Iss 1, Pp 1-17 (2020)
Cell Death & Disease
Cell Death & Disease
Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays a crucial role in mediating abnormal keratinocytes hyperproliferatio
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
RAW 264.7 cells and HUVECs were compared to evaluate the effects of dialyzed coffee extract (DCE) and artificial coffee (AC). Immunoprecipitation high performance liquid chromatography (IP-HPLC) showed DCE-2.5- (equivalent to 2.5 cups of coffee a day
Autor:
Yin Li, Nan lan, Xiefang Yuan, Zhigang Liu, Xiang He, Xing Wang, Xi Dai, Xiaoyun Wang, Bin Niu, Guoping Li, Dehong Wu, Yun Zhang, Junyi Wang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of allergen specific immunotherapy (SIT) in maintaining airway epithelial barrier function in asthma remains unknown. In the current study, we showed tha
CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation
Autor:
Esther Bandala-Sanchez, John M. Wentworth, Yuxia Zhang, Leonard C. Harrison, Timothy E. Adams, James E Vince, Swarna L Vijayaraj, Alana M. Neale, Robert J.J. O'Donoghue, Kate E. Lawlor, Maryam Rashidi
Soluble CD52 is a small glycoprotein that suppresses T-cell activation, but its effect on innate immune cell function is unknown. Here we demonstrate that soluble CD52 inhibits Toll-like receptor and tumor necrosis factor receptor signaling to limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa048f048ae761a062e0af008dbff756
https://europepmc.org/articles/PMC5762852/
https://europepmc.org/articles/PMC5762852/
In order to establish infection, intra-macrophage parasite Leishmania donovani needs to inhibit host defense parameters like inflammatory cytokine production and apoptosis. In the present study, we demonstrate that the parasite achieves both by explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f2f5efffe804940fb9b5c58ca36a5
https://europepmc.org/articles/PMC5071566/
https://europepmc.org/articles/PMC5071566/
Autor:
Gerald Münch, Sonia Sanz Muñoz, Nicole Steiner, Yizhen Wu, Jeremy S. Lum, Perminder S. Sachdev, Michael D O'Connor, Kuldip S. Sidhu, Dadong Wang, Martin Engel, Lezanne Ooi, Rachelle Balez, Pascal Vallotton
Publikováno v:
Scientific Reports
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and ne
Autor:
Jeroen Raes, Hans Clevers, Paul Rutgeerts, Lars Vereecke, Geert van Loo, Rudi Beyaert, Conor Mc Guire, Johan H. van Es, Maaike van den Born, Sara Vieira-Silva, Thomas Billiet, Mozes Sze, Severine Vermeire, Karolina Slowicka, Gert De Hertogh
Publikováno v:
Nature Communications, 5. Nature Publishing Group
The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes to chronic inflammation and inflammatory bowel disease (IBD). A20, an inhibitor of both NF-κB and apoptotic signalling, was identified as a susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a99f248a117499b9e6954767e660291
https://lirias.kuleuven.be/handle/123456789/487963
https://lirias.kuleuven.be/handle/123456789/487963