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Autor:
Jie-hui Tan, Jia Xu, Guo-wei Zhang, Yang-chen Jin, Min Luo, Xue-mei Chen, Jun-ling Zeng, Lei Zhou, Shu-ji Li, Rong-chang Cao, Guo-dong Hu, Jin Jin, Jia-yu Lin, Zhao-chang Qi, Huo-ji Chen, Zhi-tao Zhou
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains problematic due to a lack of knowledge about disease-specific regulatory targets and mechanisms. The purpose of this study was to screen proteins related to endoplasmic reticu
Autor:
Harshal Hanumant Nandurkar, Melrine Pereira, Carly Selan, Natasha Ting Lee, David W. Wright, Akram Zamani, Maithili Sashindranath, Sharelle Anne Sturgeon, Joanne S. J. Chia
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic injury, restoration of blood
Autor:
Ramesh K. Ganju, Sanjay Varikuti, Manish Charan, Nabanita Chatterjee, Swati Misri, Abhay R. Satoskar, Kirti Kaul, Dinesh K. Ahirwar, Sanjay Mishra, Subhadip Das
Publikováno v:
Cell Death and Disease, Vol 11, Iss 9, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype of highly aggressive breast cancer with worse prognosis and poor survival rate. Macrophage migration inhibitory factor (MIF) is a pleiot
Autor:
Yijian Li, Xiangfeng Liu, Guangdi Li, Huiling Li, Jian Pan, Bohao Liu, Yunchang Yuan, Xiaozhou Li, Peilin Zheng, Xudong Xiang, Xiangping Chai, Zhengyu Peng, Zhibiao He, Feng Liu, Hongliang Zhang, Dongshan Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation of proximal tubular DsbA-L for renal tubuloint
Autor:
Wei Xia, Xue Yin, Xue-fei Zhu, Bingyu Zhang, Weiming Liu, Peirong Lu, Chi Ren, Lei Chen, Gaoqin Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the macular area. Although close attention has been paid to AMD, and anti-vascular endothelial growth factor (V
Publikováno v:
Cell Death and Disease, Vol 11, Iss 1, Pp 1-17 (2020)
Cell Death & Disease
Cell Death & Disease
Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays a crucial role in mediating abnormal keratinocytes hyperproliferatio
Autor:
Ayaz Najafov, Muhah Jung, Song-Yi Lee, Jaemin Kang, Soosung Kang, Shaomeng Wang, Yong-Keun Jung, Junying Yuan, Cathena Meiling Li, Hyun-Joo Kim
Publikováno v:
Cell Death and Disease, Vol 10, Iss 12, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Upon necroptosis activation, receptor interacting serine/threonine kinase (RIPK)1 and RIPK3 form a necrosome complex with pseudokinase mixed lineage kinase-like (MLKL). Although protein phosphorylation is a key event for RIPK1 and RIPK3 activation in
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently, there is no treatment for this detrimental disorder. Development of therapies
Autor:
Irene Romayor, Alba Herrero, Bård Smedsrød, Beatriz Arteta, Aitor Benedicto, Joana Marquez, Elvira Olaso
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
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Scientific Reports
Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellat
Autor:
Tae Il Kim, Soo Jung Park, Jae Hee Cheon, Seung Won Kim, Jae Hyeon Kim, Won Ho Kim, Sujeong Hong, Hyun Jung Lee, Je-Wook Yu, Inhwa Hwang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The pathogenesis of intestinal Behçet’s disease (BD) remains poorly understood. Therefore, we aimed to discover and validate biomarkers using proteomics analysis and subsequent functional studies. After two-dimensional electrophoresis, candidate p