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pro vyhledávání: ''
Autor:
Hongxi Xiao, Yilan Zhang, Yiming Shao, Xiuli Chang, Rui Li, Yifan Zhao, Zhijun Zhou, Zhengli Yang, Fen Zhang, Qian Li, Yubin Zhang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Paraquat (PQ), a widely used herbicide, could cause neurodegenerative diseases, yet the mechanism remains incompletely understood. This study aimed to investigate the direct effect of PQ on NSC in vivo and its possible mechanism. Adult C57BL/6 mice w
Autor:
Lan-Hsiang Chien, Hung-Jung Lin, Chien-Chin Hsu, Chien-Cheng Huang, Ching-Ping Chang, Chung-Ching Chio, Mao-Tsun Lin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
To date, there is no good evidence that intestine epithelial cells (IEC) affected by ischemia/reperfusion (I/R) injury are able to cause cortical neuron injury directly. Additionally, it remains unclear whether the neuronal damage caused by I/R injur
Autor:
Jungwan Hong, Dongyeong Yoon, Youngpyo Nam, Tae Yong Lee, Kyoungho Suk, Kyung Suk Kim, Min Sung Kim, Sang Ryong Kim, Jong-Heon Kim, Ho-Won Lee, Pan-Woo Ko, Donggun Seo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Most cerebellar ataxias (CAs) are incurable neurological disorders, resulting in a lack of voluntary control by inflamed or damaged cerebellum. Although CA can be either directly or indirectly related to cerebellar inflammation, there is no suitable
Autor:
Francis Migneault, Alexandre Brodeur, Nicolas Thibodeau, Mélanie Dieudé, Marie-Pierre Hardy, Deborah Beillevaire, Claude Perreault, Julie Turgeon, Marie-Josée Hébert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Persistent endothelial injury promotes maladaptive responses by favoring the release of factors leading to perturbation in vascular homeostasis and tissue architecture. Caspase-3 dependent death of microvascular endothelial cells leads to the release
Autor:
Irene Romayor, Alba Herrero, Bård Smedsrød, Beatriz Arteta, Aitor Benedicto, Joana Marquez, Elvira Olaso
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
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Scientific Reports
Addi. Archivo Digital para la Docencia y la Investigación
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Scientific Reports
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellat
Autor:
Tae Il Kim, Soo Jung Park, Jae Hee Cheon, Seung Won Kim, Jae Hyeon Kim, Won Ho Kim, Sujeong Hong, Hyun Jung Lee, Je-Wook Yu, Inhwa Hwang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The pathogenesis of intestinal Behçet’s disease (BD) remains poorly understood. Therefore, we aimed to discover and validate biomarkers using proteomics analysis and subsequent functional studies. After two-dimensional electrophoresis, candidate p
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Chronic neuroinflammation is known to contributes to the toxicity of neurodegeneration of Parkinson’s disease (PD). However, the molecular and cellular mechanisms controlling inflammatory responses in the central nervous system remain poorly unders
Autor:
Susanne Michen, Andreas Janke, Dietmar Appelhans, Achim Temme, Alexander Hagstotz, Gabriele Schackert, Isabell Schau
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Application of Toll-like receptor (TLR) agonists is a promising approach to treat cancer. In particular, nucleic acid-based TLR agonists such as short ssRNA and dsRNA molecules, which activate endosomal TLRs, can be delivered to tumors by use of nano
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Male Wistar rats were exposed to herbicide, pendimethalin (PND) at varying oral doses of 62.5, 125 and 250 mg/kg b.w. for 14 days. Toxiological effects were assessed in terms of oxidative stress, DNA damage, histopathological alterations and inductio
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
RAW 264.7 cells and HUVECs were compared to evaluate the effects of dialyzed coffee extract (DCE) and artificial coffee (AC). Immunoprecipitation high performance liquid chromatography (IP-HPLC) showed DCE-2.5- (equivalent to 2.5 cups of coffee a day