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Autor:
Xiaohua Gong, Rongrong Le, Xiaojun Chen, Ke Xu, Shi Yujuan, Hongjin Chen, Xiaozhong Huang, Zimiao Chen, Gu Xuemei, Qihan Zhu, Feixia Shen, Chen Xiong
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to inhibit inflammation in macrophages. Herein, we investigated the ef
Publikováno v:
Scientific Reports
The role of p53 in renal fibrosis has recently been suggested, however, its function remains controversial and the underlying mechanism is unclear. Here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis,
Autor:
Inge Mannaerts, Ricard Farré, Olivier Govaere, Mathias Wenes, Petra Windmolders, Sabine Klein, Leo A. van Grunsven, Len Verbeke, Ingrid Vander Elst, Wim Laleman, Massimiliano Mazzone, Jonel Trebicka, Frederik Nevens, Robert Schierwagen
Publikováno v:
Scientific Reports
Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The Farnesoid-X receptor (FXR) antagonizes inflammation through NF-κB inhibition. We investigated preventive and therapeutic effects of FXR agonist obeticholic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf4e9af910a7f53cd0eb80d20fe7024
https://hdl.handle.net/20.500.14017/1fce66a1-b0d7-4666-866c-3092ac73fa46
https://hdl.handle.net/20.500.14017/1fce66a1-b0d7-4666-866c-3092ac73fa46