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Autor:
Xiaohua Gong, Rongrong Le, Xiaojun Chen, Ke Xu, Shi Yujuan, Hongjin Chen, Xiaozhong Huang, Zimiao Chen, Gu Xuemei, Qihan Zhu, Feixia Shen, Chen Xiong
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to inhibit inflammation in macrophages. Herein, we investigated the ef
Publikováno v:
Scientific Reports
The role of p53 in renal fibrosis has recently been suggested, however, its function remains controversial and the underlying mechanism is unclear. Here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis,