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of 241
pro vyhledávání: ''
Autor:
Qiudan Chen, Xiaotong Chen, Zhong Wu, Guanglei Song, Shihao Zhuang, Weifeng Wang, Shuying Chen, Yuan Lv, Yong Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug resistance of glioblastoma (GBM) cells. In this study, we analyzed the role and potential mechanism of l
Autor:
Huey-Jiun Ko, Chung-Hwan Chen, Chihuei Wang, Po-Hsu Chou, Cheng-Jung Ho, Tzu-Shao Liao, Xiang-Ren Zheng, Li-Ting Wang, Ru-Wei Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred
Autor:
Peijing Zhang, Shan Huang, Yiming Zeng, Manyu Zhao, Hong Luo, Zhicheng Zhou, Yuan Quan, Mengru Ma, Li Su, Lixu Tang, Jongchan Kim
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, h
Autor:
Dongxia Zhang, Yanling Lv, Jiongyu Hu, Yanhai Feng, Qiong Zhang, Yuesheng Huang, Yao Huang, Junhui Zhang, Lingfei Li, Jiezhi Jia
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Phosphorylation of MAP4 (p-MAP4) causes cardiac remodeling, with the cardiac microvascular endothelium being considered a vital mediator of this process. In the current study, we investigated the mechanism underlying p-MAP4 influences on cardiac micr
Autor:
Peiquan Zhang, Jinbao Liu, Leyi Yao, Ding Yan, Q. Ping Dou, Qingtian Huang, Xin Chen, Xiaofen Li, Qianqian Yang, Shuhui Lin, Wenshuang Sun
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously rep
Autor:
Jianping Zhang, Tian Zhan, Haojun Yang, Fan Li, Yi Dai, Yuwen Jiao, Yunwei Xia, Liming Tang, Guoguang Wang, Hanyang Liu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Platinum drug treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). However, the therapeutic effect is less than satisfactory, largely due to the acquired resistance to platinum drugs. Therefore,
Autor:
Jiarui Liu, Shuai Ren, Yang Han, Xin Wang, Xiangxiang Zhou, Shunfeng Hu, Juan Yang, Yi Zhao, Yiqing Cai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chem
Autor:
Laura J. Jenkins, Ashleigh R Poh, W.D. Fairlie, Marco Evangelista, Erinna F. Lee, Srividya B. Balachander, John M. Mariadason, Trishe Leong, Megan O'Brien, Jonathan Cebon, Surein Arulananda, Justin Cidado, Thomas John, Marzena Walkiewicz
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro, and contr
Autor:
Alexei Verkhratsky, Peter Illes, Na Xie, Zhao Huang, Yong Tang, Beáta Sperlágh, Shu-Guang Yu, Francesco Di Virgilio, Henning Ulrich, Alexey Semyanov, Canhua Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Signal Transduction and Targeted Therapy
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Signal Transduction and Targeted Therapy
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout ti
Autor:
Varisa Pongrakhananon, Pithi Chanvorachote, Onsurang Wattanathamsan, Ratchanee Rodsiri, Chanida Vinayanuwattikun, Rawikorn Thararattanobon
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
The posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance. In this study, we aimed to investigate the biological role of microtubule PTMs in the re