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Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Cell Death & Disease
Cell Death & Disease
The decrease of neurotransmitter dopamine (DA) levels in the intestine is closely related to the development of inflammatory bowel disease (IBD). However, the functional relevance and underlying mechanistic basis of the effects of DA signaling on IBD
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat
Autor:
Wael N. Hozzein, Hany R. Hashem, Ayat Tawfik, Abdelazeem M. Algammal, Reham M. El-Tarabili, Waleed M. El Kazzaz, Helal F Hetta, Gaber El-Saber Batiha
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
This study aimed to evaluate the prevalence, multidrug-resistance traits, PCR-detection of virulence, and antibiotic-resistance genes of E. coli isolated from secondary infections following FMD-outbreak in cattle. A total of 160 random samples were g
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Medaka (Oryzias latipes) is a teleost fish with an XX/XY sex determination system, similar to that of mammals. However, under high temperature conditions, XX medaka is masculinised by elevation of cortisol, the major teleost glucocorticoid. In this s
Autor:
László Makrai, Dóra Tőzsér, Adrienn Gréta Tóth, István Csabai, Á Patai, Norbert Solymosi, Gergely Maróti, Eszter Krikó, Géza Szita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
The increasing prevalence of antimicrobial resistance (AMR) is a significant threat to global health. More and more multi-drug-resistant bacterial strains cause life-threatening infections and the death of thousands of people each year. Beyond diseas
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
Recent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resist
Autor:
Jean-Martin Beaulieu, Helia Tenza-Ferrer, Jivan Khlghatyan, Luiz Alexandre V. Magno, Thomas Del’Guidice, Eduardo de Souza Nicolau, Mélcar Collodetti, Marco Aurélio Romano-Silva
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Peripheral biomarker and post-mortem brains studies have shown alterations of neuronal calcium sensor 1 (Ncs-1) expression in people with bipolar disorder or schizophrenia. However, its engagement by psychiatric medications and potential contribution
Autor:
Jasmien Wellens, Keith R. Mehalek, Harbir S. Dhillon, Agnieszka Wozniak, Sneha S. Patil, Aya Agha, Kathleen R. Makielski, Yemarshet K. Gebreyohannes, Areej A. Ali, Anette Duensing, Jessica L. Rausch, Maria Debiec-Rychter, Yanis Tolstov, Patrick Schöffski, Donna M. Lee
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The majority of gastrointestinal stromal tumors (GISTs) are driven by oncogenic KIT signaling and can therefore be effectively treated with the tyrosine kinase inhibitor (TKI) imatinib mesylate. However, most GISTs develop imatinib resistance through
Autor:
Julia Sanchez-Garrido, Nitya Krishnan, Avinash R. Shenoy, Brian D. Robertson, Sathyavani Subbarao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Mycobacterium tuberculosis infection causes high rates of morbidity and mortality. Host-directed therapy may enhance the immune response, reduce tissue damage and shorten treatment duration. The inflammasome is integral to innate immune responses but
Autor:
Joanne Cable, Daniela Rosado, Ricardo Severino, Fernando Tavares, Marcos Pérez-Losada, Raquel Xavier
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
The mucosal surfaces of fish harbour microbial communities that can act as the first-line of defense against pathogens. Infectious diseases are one of the main constraints to aquaculture growth leading to huge economic losses. Despite their negative