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Publikováno v:
Blood Cancer Journal, Vol 11, Iss 3, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Immunotherapy has shown efficacy in relapsed multiple myeloma (MM). However, these therapies may depend on a functional tumor immune microenvironment (iTME) for their efficacy. Characterizing the evolution of the iTME over the disease course is neces
Publikováno v:
Oncogene. 39:5867-5875
Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplan
Autor:
Huijuan Wu, Hongbo Wu, Lijuan Chen, Xiufeng Hu, Yu Mu, Fangfang Yuan, Lei Liu, Wenjing Liu, Xiaoqian Mu, Jie Liu, Yanqiu Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 9, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Exosomes are small endogenous membrane vesicles that can mediate cell communication by transferring genetic materials. Based on that, exosomes have always been discussed as a cargo carrier for microRNA (miRNA) transportation. Accumulating data have r
Autor:
Yabo Ouyang, Dexi Chen, Lijun Pang, Xianghua Guo, Ronghua Jin, Jiming Yin, Ying-Mei Feng, Hongbo Shi, Honglin Shi, Wenjing Wang, Luxin Qiao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 6, Pp 1-8 (2020)
Cell Death & Disease
Cell Death & Disease
Background: Although most patients with COVID-19 pneumonia have a good prognosis, some patients develop to severe or critical cases, and the mortality of critical cases was up to 61.5%. However, specific information and molecular mechanism about crit
Autor:
Gian Paolo Spinelli, Rosalba Caccavale, Carmela Martire, Ilenia Cammarata, Paolo Visca, Sheila Spada, Felice Giangaspero, Paola Nisticò, Silvia Piconese, Silverio Tomao, Chiara Focaccetti, Fabiana Letizia Cecere, Gabriella Girelli, Julio Rodrigo Giròn Berrìos, Flavia Longo, Federica Buzzacchino, Carmine Mancone, Marino Paroli, Giovanna Peruzzi, Vincenzo Barnaba, Marta Buccilli, Mariangela Panetta, Alessio Grimaldi, Nicoletta D'Alessandris, Francesco Facciolo
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Here, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with th
Autor:
Tadakazu Shimoda, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa, Kiron M. Das, Chiyomi Ito, Jiro Watari, Tadayuki Oshima
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
The risk of gastric cancer (GC) declines after Helicobacter pylori (H. pylori) eradication and long-term aspirin use. We evaluated the effects of H. pylori eradication (Cohort 1) and aspirin use (Cohort 2) on the methylation of microRNAs (miRNAs), su
Autor:
Gurcan Tunali, Yahya Buyukasik, Tolga Sutlu, Digdem Yoyen-Ermis, Gunes Esendagli, Didem Ozkazanc, Ece Tavukcuoglu, Utku Horzum
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leu
Autor:
Alessandro Cherubini, Francesco Maria Crisà, Elena Trombetta, Laura Guarnaccia, Laura Riboni, Laura Fontana, Monica Miozzo, Rolando Campanella, Marco Locatelli, Chiara Cordiglieri, Paolo Rampini, Manuela Caroli, Stefania Elena Navone, Giovanni Marfia
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Gliomas are the most common brain tumors, with diverse biological behaviour. Glioblastoma (GBM), the most aggressive and with the worst prognosis, is characterized by an intense and aberrant angiogenesis, which distinguishes it from low-grade gliomas
Autor:
Zita Borbényi, Suddhasatta Acharyya, Karen W.L. Yee, Je-Hwan Lee, Massimo Breccia, S. Ide, Árpád Illés, Alan Macwhannell, Carlos Graux, Miklos Egyed, Nancy Zhu, David Valcárcel, James D. Cavenagh, Reinhard Stauder, Huda Salman, Daniel J. DeAngelo, Mikkael A. Sekeres, M. Marker, Oliver G. Ottmann, G. Garcia-Manero, Lucien Gazi, Pierre Fenaux
Publikováno v:
Leukemia
Treatment with azacitidine (AZA), a demethylating agent, prolonged overall survival (OS) vs conventional care in patients with higher-risk myelodysplastic syndromes (MDS). As median survival with monotherapy is
Autor:
Sook Ryun Park, Sohei Matsumoto, Hiroshi Honda, Kyung Hee Lee, Seokyung Hahn, Hyuk Joon Lee, Min Hee Ryu, Han-Kwang Yang, Jeong Hwan Yook, Haruhiko Cho, Toru Masuzawa, Yukinori Kurokawa, Takashi Ishikawa, Toshio Shimokawa, Seock-Ah Im, Oh Kyoung Kwon, Seiichi Hirota, Seong Ho Kong, Toshirou Nishida, Kazuhito Nabeshima, Yuichiro Doki, Yoon-Koo Kang
Publikováno v:
British Journal of Cancer
Background: Gastrointestinal stromal tumours (GISTs) with high-risk features have poor prognosis even if adjuvant treatment is given. Neoadjuvant imatinib may increase the cure rate by shrinking large GISTs and preserve organ function. Methods: We co