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pro vyhledávání: ''
Autor:
Kenneth Aldape, Sheila Mansouri, Yasin Mamatjan, Suganth Suppiah, Gelareh Zadeh, Shirin Karimi, Farshad Nassiri, Olivia Singh, Jeff C. Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Management of clinically aggressive meningiomas is a considerable challenge. PD-L1 induced immune suppression has increasingly gained attention in clinical management of cancer; however, to date, the clinical significance and regulatory mechanisms of
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients
Autor:
Chang Gok Woo, Hyo Yung Yun, Hee Kyung Kim, Su-Hyung Park, Seung Myoung Son, Hyung-Don Kim, Jihyun Kwon, June Young Koh, Hongsik Kim, Tae Yong Kim, Minsuk Kwon, Hye Sook Han, Yaewon Yang, Dae Hoon Kim, Eui-Cheol Shin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic gastric cancer (MGC). CD4+ and CD8+ T-cell density and PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatc
Autor:
Åsa Kågedal, Ola Winqvist, Lars-Olaf Cardell, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Pedro Farrajota Neves da Silva, Valtteri Häyry, Eric Hjalmarsson, Eva Munck-Wikland
Publikováno v:
British Journal of Cancer
Background: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. Methods: We analysed 4
Autor:
Wolfgang Hiddemann, Eike Bormann, Christoph Schliemann, Caroline Pabst, Linus Angenendt, Tobias Herold, Guy Sauvageau, Maria Francisca Arteaga, Klaus H. Metzeler, Klaus Wethmar, Wolfgang E. Berdel, Hubert Serve, Vijay Alla, Jan-Henrik Mikesch, Carsten Müller-Tidow, Georg Lenz, Kim Dohlich, Bob Löwenberg, Wolfgang Hartmann, Torsten Kessler, Adrian Angenendt, Matthias Stelljes, Rolf M. Mesters, Peter J. M. Valk, Karsten Spiekermann, Josée Hébert, Dennis Görlich, Stefan K. Bohlander, Utz Krug, Christian Schwöppe, M Christina Sauerland, Bernhard Wörmann, Leonie Braun, Maja Rothenberg-Thurley
Publikováno v:
Leukemia 33, 2830-2841 (2019)
Leukemia, 33(12), 2830-2841. Nature Publishing Group
Leukemia, 33(12), 2830-2841. Nature Publishing Group
Calcitonin receptor-like (CALCRL) is a G-protein-coupled neuropeptide receptor involved in the regulation of blood pressure, angiogenesis, cell proliferation, and apoptosis, and is currently emerging as a novel target for the treatment of migraine. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845323dcc3018ec9a3bc8d294f1472fe
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56286
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56286
Autor:
Luca Mastracci, Giada Munari, Fotios Loupakis, Marco Scarpa, Stefano Brignola, Antonio Pellino, Giuseppe Nicolò Fanelli, Giovanni Zaninotto, Rocco Cappellesso, Gábor Lotz, Irene Coati, Nicola Valeri, Matteo Fassan, Salvatore Pucciarelli, Vincenza Guzzardo, Gaya Spolverato, Cristiano Lanza, Massimo Rugge, Pierluigi Pilati, Fabio Farinati, Sara Lonardi, András Kiss, Stefano Realdon
Publikováno v:
British Journal of Cancer
Background Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform of CLDN18, the Claudin 18.2, has recently emerged as an innovative drug target for metastatic gastric cancer. Methods We investigated the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c49e3cab41d0b558e584f8a1baea2f
http://hdl.handle.net/11567/970163
http://hdl.handle.net/11567/970163
Publikováno v:
British Journal of Cancer
Background: Oral squamous cell carcinomas have high potential for locoregional invasion and nodal metastasis. Thus, early detection and elucidation of detailed molecular mechanisms of OSCCs are important. Roles of LEM domain containing 1 (LEMD1), a n
Autor:
Jenny Chang-Claude, Curtis Olswold, Veli-Matti Kosma, Penny Coulson, Jonine D. Figueroa, Qin Wang, Melissa C. Southey, Paul D.P. Pharoah, Manjeet K. Bolla, Carl Blomqvist, Vesa Kataja, Janet E. Olson, Graham G. Giles, H. Raza Ali, Rulla M. Tamimi, A. Heather Eliassen, Hyuna Sung, Angela Cox, Douglas F. Easton, Heli Nevanlinna, Päivi Heikkilä, Fergus J. Couch, William J. Howat, Marjanka K. Schmidt, Xiaohong R. Yang, Reijo Sironen, Rainer Fagerholm, Emily Hallberg, Roger L. Milne, Fiona M. Blows, Simon S. Cross, Montserrat Garcia-Closas, Mark E. Sherman, Catriona McLean, Peter Kraft, Arto Mannermaa
Publikováno v:
British Journal of Cancer
Background: Luminal A breast cancer defined as hormone receptor positive and human epidermal growth factor receptor 2 (HER2) negative is known to be heterogeneous. Previous study showed that luminal A tumours with the expression of basal markers ((cy
Autor:
Thomas Hermanns, Sophia Sander, Joerg Beyer, Oliver Gross, Lisa Roth, Christian D. Fankhauser, Tullio Sulser, Burkhardt Seifert, Daniel Eberli
Publikováno v:
British Journal of Cancer
Fankhauser, Christian Daniel; Sander, Sophia; Roth, Lisa; Gross, Oliver; Eberli, Daniel; Sulser, Tullio; Seifert, Burkhardt; Beyer, Jörg; Hermanns, Thomas (2018). Systemic inflammatory markers have independent prognostic value in patients with metastatic testicular germ cell tumours undergoing first-line chemotherapy. British journal of cancer, 118(6), pp. 825-830. Nature Publishing Group 10.1038/bjc.2017.467
Fankhauser, Christian Daniel; Sander, Sophia; Roth, Lisa; Gross, Oliver; Eberli, Daniel; Sulser, Tullio; Seifert, Burkhardt; Beyer, Jörg; Hermanns, Thomas (2018). Systemic inflammatory markers have independent prognostic value in patients with metastatic testicular germ cell tumours undergoing first-line chemotherapy. British journal of cancer, 118(6), pp. 825-830. Nature Publishing Group 10.1038/bjc.2017.467
BACKGROUND The prognostic utility of systemic inflammatory markers has so far not been investigated in patients with metastatic testicular germ cell tumours (GCTs). METHODS International Germ Cell Cancer Cooperative Group (IGCCCG) risk groups and blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd85893c88e7ff55d3d80f5322a81258
Publikováno v:
British Journal of Cancer
Background: It has recently been shown that WISP proteins (Wnt-inducted secreted proteins), a group of intra- and extra-cellular regulatory proteins, have been implicated in the initiation and progression of a variety of tumour types including colore
Autor:
Zeenath Jehan, Shaham Beg, F Al-Dayel, Abdul K. Siraj, S Prabakaran, Saif S. Al-Sobhi, Mohammed Al-Dawish, Khawla S. Al-Kuraya
Publikováno v:
British Journal of Cancer
Background: PTEN gene at chromosomes 10q23.3 is a tumour suppressor gene that is inactivated in many types of human cancers. The known mechanisms of PTEN inactivation are rendered to mutation, epigenetic silencing by aberrant methylation or gene dele