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Autor:
Giorgio Durante, Cosimo Misciali, Martina Lambertini, Cristian Bassi, Massimo Negrini, Elisa Porcellini, Eric Londin, Mattia Riefolo, Isidore Rigoutsos, Roberta Roncarati, Phillipe Loher, Emi Dika, Annalisa Patrizi, Manuela Ferracin, Elisabetta Broseghini
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades. During their lifetime, about 8% of CM patients will develop multiple primary melanomas (MPMs
Autor:
Ling Li, Quanxin Long, Li Liu, Xiaoyong Zhang, Yanqun Wang, Hong Zhu, Sheng Nie, Ailong Huang, Jinlin Hou, Xin Xu, Jian Sun, Fan Fan Hou, Jincun Zhao, Qinglang Zeng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Our understanding of the protective immunity, particularly the long-term dynamics of neutralizing antibody (NAbs) response to SARS-CoV-2, is currently limited. We enrolled a cohort of 545 COVID-19 patients from Hubei, China, who were followed up up t
Autor:
Rita Mendes, Teresa F. Mendes, Marta Teixeira, Vítor E. Santo, Catarina Brito, Sofia Abreu, Fernanda Silva, Erwin R. Boghaert, Ana Félix
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Ovarian carcinoma (OvC) remains a major therapeutic challenge due to its propensity to develop resistance after an initial response to chemotherapy. Interactions of tumour cells with the surrounding microenvironment play a role in tumour survival, in
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
Autor:
Liang Jin, Zijie Cai, Hongna Lai, Ying Li, Zongqi Wu, Erwei Song, Yujie Liu, Jingru Wang, Qiang Liu, Yudong Li, Mengdi Zhu, Shunying Li, Qianfeng Shi, Qian Li, Yanqing Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-r
Autor:
Caroline Brenner Thomsen, Ivan Brandslund, Dorte Aa. Olsen, Jonna Skov Madsen, Rikke F. Andersen, Anders Jakobsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Olsen, D A, Thomsen, C E B, Andersen, R F, Madsen, J S, Jakobsen, A & Brandslund, I 2020, ' Decreased concentrations of intracellular signaling proteins in colon cancer patients with BRAF mutations ', Scientific Reports, vol. 10, 20113 . https://doi.org/10.1038/s41598-020-77109-8
Scientific Reports
Olsen, D A, Thomsen, C E B, Andersen, R F, Madsen, J S, Jakobsen, A & Brandslund, I 2020, ' Decreased concentrations of intracellular signaling proteins in colon cancer patients with BRAF mutations ', Scientific Reports, vol. 10, 20113 . https://doi.org/10.1038/s41598-020-77109-8
The activation of intracellular signaling pathways plays a critical role in cancer pathogenesis. The current study aims to quantify intracellular signaling proteins in localized colon cancer tissue to investigate the prognostic value of these biomark
Autor:
Ryul Kim, Sung Soo Yoon, Keonyong Lee, Nam Hoon Kwon, Yoosik Kim, Sunghoon Kim, Youngil Koh, Namseok Lee, Min A. Kim, Daeyoon Kim, Seulki Song, Dongchan Kim, Jayoung Ku
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications biology, vol 3, iss 1
Communications Biology
Communications biology, vol 3, iss 1
Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity a
Autor:
Dan Li, Guoping Ding, Weimin Wang, Xiaodong Xu, Dongnan Ping, Liping Cao, Shengnan Jia, Yuhao Chen
Publikováno v:
Cell Death and Disease, Vol 11, Iss 10, Pp 1-17 (2020)
Cell Death & Disease
Cell Death & Disease
Pancreatic adenocarcinoma (PDAC) is an extremely malignant tumor that is associated with low survival rates. Fisetin is a natural flavonoid that shows diverse antitumor effects, including DNA damage, in various cancers. Increasing studies have demons
Autor:
Han-Sin Jeong, Sanghoon Song, Young-Wook Kim, Keunchil Park, Joon Ho Kang, Woong-Yang Park, Teresa Swatloski, Young-Hyeh Ko, Miran Lee
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Salivary duct carcinoma (SDC) is one of the most aggressive subtypes of salivary gland cancers. Conventional chemotherapy and/or radiation have shown only limited clinical efficacy in the treatment of recurrent or metastatic SDC. Currently, clinicall
Autor:
Gavin W. Wilson, Sangeetha N Kalimuthu, Jonathan Allen, Nikolina Radulovich, Mathieu Derouet, Ming-Sound Tsao, Gail Darling, Jonathan C. Yeung, Christine Ng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Esophageal adenocarcinoma has few known recurrent mutations and therefore robust, reliable and reproducible patient-specific models are needed for personalized treatment. Patient-derived organoid culture is a strategy that may allow for the personali
Autor:
Kenneth Aldape, Sheila Mansouri, Yasin Mamatjan, Suganth Suppiah, Gelareh Zadeh, Shirin Karimi, Farshad Nassiri, Olivia Singh, Jeff C. Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Management of clinically aggressive meningiomas is a considerable challenge. PD-L1 induced immune suppression has increasingly gained attention in clinical management of cancer; however, to date, the clinical significance and regulatory mechanisms of