Zobrazeno 1 - 10
of 86
pro vyhledávání: ''
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
Autor:
Liang Jin, Zijie Cai, Hongna Lai, Ying Li, Zongqi Wu, Erwei Song, Yujie Liu, Jingru Wang, Qiang Liu, Yudong Li, Mengdi Zhu, Shunying Li, Qianfeng Shi, Qian Li, Yanqing Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-r
Autor:
Ryul Kim, Sung Soo Yoon, Keonyong Lee, Nam Hoon Kwon, Yoosik Kim, Sunghoon Kim, Youngil Koh, Namseok Lee, Min A. Kim, Daeyoon Kim, Seulki Song, Dongchan Kim, Jayoung Ku
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications biology, vol 3, iss 1
Communications Biology
Communications biology, vol 3, iss 1
Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity a
Autor:
Shuji Momose, Michihide Tokuhira, Morihiro Higashi, Yuka Tanaka, Takahisa Yamashita, Akiko Adachi, Jun-ichi Tamaru, Toshiki Watanabe, Masahiro Kizaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
MYC-associated factor X (MAX) is a protein in the basic helix-loop-helix leucine zipper family, which is ubiquitously and constitutively expressed in various normal tissues and tumors. MAX protein mediates various cellular functions such as prolifera
Autor:
Johannes H. Dreyer, Maike Büttner-Herold, Laura Werner, Ulrike Grittner, Gerald Niedobitek, David Hartmann, Mário Henrique M. Barros
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Commonly attributed to the prevalence of M2 macrophages, tumor-associated macrophages (TAM) are linked to poor outcome in Hodgkin lymphoma (HL). MYC is supposed to control the expression of M2-specific genes in macrophages, and deficiency in MYC-posi
Publikováno v:
Cancer Gene Therapy, 27(1-2), 30-37. Nature Publishing Group
Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. Genetic abnormalities are powerful prognostic factors. P21-activated kinases (PAKs) are a kind of serine/threonine protein kinases, which
Autor:
Jessica Becker, Jan Rehkämper, Heidrun Gevensleben, Eva Wardelmann, Inga Grünewald, Wolfgang Hartmann, Marcel Trautmann, Sebastian Huss
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Desmoid-type fibromatosis (DTF, aggressive fibromatosis) is a non-metastasizing mesenchymal neoplasm of deep soft tissue with a tendency towards local recurrence. Genetic alterations affecting canonical Wnt/β-catenin signaling are reported in the ma
Autor:
Xue-mei Huang, Peng Zhang, Shun Lu, Yimin Liu, Jinyi Lang, Ping Yi, Chun-ting Wang, Jian Han, Jun Liu, Qi Zeng, Jianxin Guo
Publikováno v:
Cell Death and Disease, Vol 10, Iss 8, Pp 1-14 (2019)
Cell Death & Disease
Cell Death & Disease
ZIP4 is a zinc transporter involved in epithelial cell morphology and migration in various cancers. In the epithelial-to-mesenchymal transition (EMT), epithelial cells transition into mesenchymal cells. The EMT plays a crucial role in invasiveness an
Publikováno v:
Cell Death and Disease, Vol 10, Iss 3, Pp 1-17 (2019)
Cell Death & Disease
Cell Death & Disease
Chemokine receptors have been documented to exert critical functions in melanoma progression. However, current drugs targeting these receptors have limited efficacy in clinical applications, suggesting the urgency to further explore the roles of chem
Autor:
Chiou-Hwa Yuh, Shih Sheng Jiang, Chun Nan OuYang, Ngan Ming Tsang, Shu Chen Liu, Tien Hsu, An Ko Chung, Yu-Sun Chang, Ya Ping Liu, Chuen Hsueh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, s
Autor:
Zhi Liu, Jiankang Liu, Ruilian Li, Changji Li, Suju Luo, Zhengxiao Li, Jiao Yang, Jinjing Jia, Yan Zheng, Xin Wang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Psoriasis is a chronic inflammatory skin disease with high morbidity, poor treatment methods and high rates of relapse. Keratinocyte hyperproliferation and shortened cell cycles are important pathophysiological features of psoriasis. As a known oncog