Zobrazeno 1 - 10
of 20
pro vyhledávání: '"59"'
Publikováno v:
British Journal of Cancer
Background: Adjuvant trastuzumab with chemotherapy is standard treatment for HER2-positive breast cancer, defined as either HER2 IHC3+ or IHC2+ and FISH amplified. The aim of this study was to investigate the degree to which HER2 amplification in ter
Autor:
Hans-Detlev Saeger, Holger Kalthoff, Hans K. Schackert, Frank Dobrowolski, Robert Grützmann, Christian Pilarsky, G. Klöppel, Stephan Kersting, Jutta Lüttges, Ole Ammerpohl, Bence Sipos, Rainer Koch, Ingo Alldinger, Detlef Ockert
Publikováno v:
British Journal of Cancer
Gene expression profiling revealed ADAM9 to be distinctly overexpressed in pancreatic ductal adenocarcinoma (PDAC). We examined the relevance of ADAM9 expression in PDAC diagnosis and prognosis. A total of 59 infiltrating PDACs, 32 specimens from pat
Autor:
Zhaohui Zheng, Wen Kang, Mingru Zhang, Ya-Tao Wang, Kui Zhang, Jin Ding, Likun Ding, Yanyan Jia, Ye Zhang, Xiang-Min Yang, Aidong Wen, Ding Wei, Bin Wang, Li-Juan Wang, Lin-Na Liu, Yu-Meng Zhu, Xue Liang, Yi-Nan Ma, Hao Tang, Guoquan Li, Jing Wang, Jie-Lai Xia, Yang Zhang, Hong Du, Zhe Zhang, Xiu-Xuan Sun, Rong-Hua Xie, Jie-Jie Geng, Ke Wang, Ling Wang, Na Yao, Xiao-Chun Chen, Ke Dong, Qing-Yi Wang, Shuang-Shuang Liu, Ping Zhu, Jian-Qi Lian, Junfeng Jia, Qian He, Zhe Wang, Rui-Rui Yao, Zhi-Nan Chen, Ting Guo, Huijie Bian, Chun-Qiu Hao, Jinlin Miao, Wen-Zhen Kang, Di Zhang, Lu-Hua Gao, Xu Yang, Zhao-Wei Gao, Fei Huo, Zheng Zhang, Ruo Chen, Qing Wang, Jian-Sheng Zhou, Ying Shi, Zhiqin Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
sRecent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is a hum
Autor:
Carsten Weishaupt, Michael Geier, Andrea Forschner, Friedegund Meier, Ursula Dietrich, Jessica C. Hassel, Patrick Clemens, Markus Hecht, Stephan Grabbe, Ralf Gutzmer, Bülent Polat, Ricarda Rauschenberg, Carmen Loquai, Rainer Fietkau, Felix Kiecker, Lisa Zimmer, Carola Berking, Dirk Schadendorf, Simone M. Goldinger, Gerhard G. Grabenbauer, Luitpold Distel, Gerold Schuler, Jochen Utikal, Lucie Heinzerling, Panagiotis Balermpas
Publikováno v:
British Journal of Cancer
Background: Concomitant radiation with BRAF inhibitor (BRAFi) therapy may increase radiation-induced side effects but also potentially improve tumour control in melanoma patients. Methods: A total of 155 patients with BRAF-mutated melanoma from 17 Eu
Autor:
Louise E. Daly, S. Cushen, Derek G. Power, Henry Paul Redmond, Kathleen O'Sullivan, Maria Twomey, Paul Donnellan, David P Woodlock, Aoife M. Ryan, Aine O'Reilly
Publikováno v:
British Journal of Cancer
Background: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict Ipi toxicity and efficacy ex
Autor:
D.M. Busz, Adelita V. Ranchor, Johannes A. Langendijk, M Woltman-van Iersel, John H. Maduro, de Gh Bock, E.J. Bantema-Joppe, van den Er Edwin Heuvel
Publikováno v:
British Journal of Cancer
British Jounal of Cancer, 112(4), 636-643. Nature Publishing Group
British Journal of Cancer, 112, 636-643. Nature Publishing Group
British Jounal of Cancer, 112(4), 636-643. Nature Publishing Group
British Journal of Cancer, 112, 636-643. Nature Publishing Group
Background: The purpose of the study was to determine the impact of young age on health-related quality of life (HRQoL) by comparing HRQoL of younger and older breast cancer patients, corrected for confounding, and of young patients and a general Dut
Publikováno v:
British Journal of Cancer
Background: Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rat
Autor:
Takeo Nomi, Y Nakajima, Ichiro Yamato, Hiromichi Kanehiro, Hideo Yagita, Takahiro Akahori, Kiyohiko Hotta, Masayuki Sho, Noboru Konishi, Keiji Shimada
Publikováno v:
British Journal of Cancer
Background: B7-H3 is a new member of the B7 ligand family and regulates T-cell responses in various conditions. However, the role of B7-H3 in tumour immunity is largely unknown. The purpose of this study was to evaluate the clinical significance of B
Autor:
Nobumichi Tanaka, Yoshihiko Hirao, Kiyohide Fujimoto, Yoshitomo Chihara, Motoyoshi Tanaka, Kazumasa Torimoto, Hideyuki Akaza, Naoto Miyanaga, Akihide Hirayama, Tatsuo Yoneda
Publikováno v:
Prostate Cancer and Prostatic Diseases
The aim of this study was to evaluate the effect of supplementing healthy men with soy isoflavones on the serum levels of sex hormones implicated in prostate cancer development. A total of 28 Japanese healthy volunteers (18 equol producers and 10 equ
Autor:
David Wellsted, F Daley, Anwar R. Padhani, Andrew Gaya, Richard H. J. Begent, RB Pedley, Gillian M. Tozer, G. J. S. Rustin, N J Taylor, J. James Stirling, U Qureshi
Publikováno v:
British Journal of Cancer
Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic change