Zobrazeno 1 - 10
of 258
pro vyhledávání: ''
Autor:
Lianpeng Chang, Xin Yi, Xuefeng Xia, Ming Chen, Yanfang Guan, Zhipeng Zhou, Pansong Li, Ling Yang, Rongrong Chen, Zhengbo Song, Yiping Zhang, Guoping Cheng, Wenxian Wang, Rongrong Zhou
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Brain metastasis (BM) is a common malignant event in lung cancer. Here, we recruited 33 lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor immune microenvironment (TIME) of the lung and BM independently. For ge
Autor:
Qinfeng Mu, Jun Zhang, Ying Zhou, Haixiang Xue, Tongbing Chen, Jisheng Liu, Miaomei Yu, Guanghua Luo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this stu
Autor:
Peter Bergman, Laia Gorchs, Alisa Knauf, Elena Rangelova, Rainer Heuchel, Chanté Mayer, Sultan Ahmed, Mattias Svensson, Carlos Fernández Moro, Helen Kaipe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact of calcipotriol, a vitamin D3 analogue, on the activation of human
Autor:
Zhipeng Meng, Minmin Zhu, Huanzhong He, Xuefang Shen, Qichao Wu, Yuqin Hu, Qing Hua, Jing Liu, Jing Wang, Xiangyuan Chen, Yanguang Su, Wanxia Xiong, Zhiyao Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1715-1729 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 partic
Publikováno v:
Cell Death and Disease, Vol 11, Iss 8, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
Androgen receptor (AR) signaling is a major driver of prostate cancer (CaP). Although most therapies targeting AR are initially effective in CaP patients, drug resistance is inevitable, mainly because of the inappropriate re-activation of AR pathway.
Autor:
Huijuan Wu, Hongbo Wu, Lijuan Chen, Xiufeng Hu, Yu Mu, Fangfang Yuan, Lei Liu, Wenjing Liu, Xiaoqian Mu, Jie Liu, Yanqiu Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 9, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Exosomes are small endogenous membrane vesicles that can mediate cell communication by transferring genetic materials. Based on that, exosomes have always been discussed as a cargo carrier for microRNA (miRNA) transportation. Accumulating data have r
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients
Autor:
Chang Gok Woo, Hyo Yung Yun, Hee Kyung Kim, Su-Hyung Park, Seung Myoung Son, Hyung-Don Kim, Jihyun Kwon, June Young Koh, Hongsik Kim, Tae Yong Kim, Minsuk Kwon, Hye Sook Han, Yaewon Yang, Dae Hoon Kim, Eui-Cheol Shin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic gastric cancer (MGC). CD4+ and CD8+ T-cell density and PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatc
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Carlos Fernandez-del Castillo, Andrew S. Liss, Matteo Ligorio, Eric Tai, Chittampalli Yashaswini, A. W. K. Liu, David P. Ryan, Julia Philipp, Daniel A. Haber, Huili Zhu, Anupriya S. Kulkarni, Pavlos Missios, Elizabeth M. Tassoni, Joseph W. Franses, Theodore S. Hong, Niyati Desai, Annamaria Szabolcs, Irun Bhan, George Q. Daley, David T. Ting, Benjamin Nicholson, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-i
Publikováno v:
Cell Death and Disease, Vol 11, Iss 7, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
The excessive activation and proliferation of lung fibroblasts are responsible for the abundant deposition of extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF), while its specific mechanism is still unknown. This study focuses on the
Autor:
Shuji Momose, Michihide Tokuhira, Morihiro Higashi, Yuka Tanaka, Takahisa Yamashita, Akiko Adachi, Jun-ichi Tamaru, Toshiki Watanabe, Masahiro Kizaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
MYC-associated factor X (MAX) is a protein in the basic helix-loop-helix leucine zipper family, which is ubiquitously and constitutively expressed in various normal tissues and tumors. MAX protein mediates various cellular functions such as prolifera