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of 43
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Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Autor:
Xiao Ming Xu, Risset Silvera, Vladimir Camarena, Gaofeng Wang, Kaiwen Peng, Regina M. Graham, Natalia Denise Andersen, David W. Sant, Gonzalo Piñero, Aisha Khan, Paula V. Monje
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Nerve-derived human Schwann cell (SC) cultures are irreplaceable models for basic and translational research but their use can be limited due to the risk of fibroblast overgrowth. Fibroblasts are an ill-defined population consisting of highly prolife
Autor:
Bohumila Jurkovicova-Tarabova, Miriam Kolnikova, Ludevit Kadasi, Lubica Lacinova, Andrea Soltysova, Tomas Foltan, Andrej Ficek, Viktor Demko, Daniela Kluckova
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Mutations in the voltage-gated sodium channel Nav1.1 (SCN1A) are linked to various epileptic phenotypes with different severities, however, the consequences of newly identified SCN1A variants on patient phenotype is uncertain so far. The functional i
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Smooth muscle cell migration is essential for many diverse biological processes such as pulmonary/cardiovascular development and homeostasis. Abi1 (Abelson interactor 1) is an adapter protein that has been implicated in nonmuscle cell migration. Howe
Autor:
Zhiwei Liao, Saideng Lu, Shengfeng Zhan, Xinghuo Wu, Cao Yang, Shuai Li, Yu Song, Xiaobo Feng, Huipeng Yin, Bingjin Wang, Liang Ma, Hang Liang, Yukun Zhang, Kun Wang, Gaocai Li, Rongjin Luo, Kangcheng Zhao, Wencan Ke
Publikováno v:
Cell Death and Disease, Vol 11, Iss 2, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
N6 methyladenosine (m6A) is one of the most prevalent epitranscriptomic modifications of mRNAs, and plays a critical role in various bioprocesses. Bone-derived mesenchymal stem cells (BMSCs) can attenuate apoptosis of nucleus pulposus cells (NPCs) un
Autor:
Heng-Pei Ang, Hon Shing Ong, Stephen Wahlig, Khadijah Adnan, F. Morales-Wong, Chan N. Lwin, Matthew Lovatt, Gary S L Peh, Jodhbir S. Mehta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
As the cornea is one of the most transplanted tissues in the body it has placed a burden on the provision of corneas from cadaveric donors. Corneal endothelial dysfunction is the leading indication for cornea transplant. Therefore, tissue engineering
Autor:
Gabriel Neiman, Fernanda Mesquita, Marcus N. dos Santos, Emiliano Medei, Gustavo Monnerat, Antonio Carlos Carvalho, Fernanda Gubert, Raiana A. Q. Barbosa, Isadora M. Vaz, Jorge L. Coutinho, Danúbia Silva dos Santos, Paulo C. Arantes, Adriana Bastos Carvalho, Tamara Borgonovo, Santiago Gabriel Miriuka, Dayana S. Araujo, Isabela de Carvalho Leitão, Fernando Cruz, Tais Hanae Kasai-Brunswick
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 long QT syndrome (LQTS2)-asso
Autor:
Manuel Mata Forsberg, Eva Sverremark-Ekström, Ludwig Lundqvist, Sophia Björkander, Yanhong Pang, Stefan Roos, Mama Ndi, Martin Ott, Irene Buesa Escribá, Marie-Charlotte Jaeger
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Secreted factors derived from Lactobacillus are able to dampen pro-inflammatory cytokine responses. Still, the nature of these components and the underlying mechanisms remain elusive. Here, we aimed to identify the components and the mechanism involv
Autor:
Qianyu Zhuang, Robert Chunhua Zhao, Ye Buqing, Shangyi Hui, Fan Zusen, Li Na, Yunfei Chen, Jing Li, Jianguo Zhang, Junfen Fan
Publikováno v:
Cell Death and Disease, Vol 10, Iss 11, Pp 1-14 (2019)
Cell Death & Disease
Cell Death & Disease
Adolescent idiopathic scoliosis (AIS) is a complex, three-dimensional deformity of the spine that commonly occurs in pubescent girls. Decreased osteogenic differentiation and aberrant melatonin signalling have been demonstrated in mesenchymal stem ce
Publikováno v:
Cell Death and Disease, Vol 10, Iss 3, Pp 1-17 (2019)
Cell Death & Disease
Cell Death & Disease
Chemokine receptors have been documented to exert critical functions in melanoma progression. However, current drugs targeting these receptors have limited efficacy in clinical applications, suggesting the urgency to further explore the roles of chem