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of 111
pro vyhledávání: ''
Autor:
Song Wu, Anli Yang, Cheng Peng, Shunling Ou, Xing Li, Zhongying Huang, Lewei Zhu, Peng Liu, Fu Peng, Yanan Kong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Melatonin has been reported to have tumor-suppressive effects via comprehensive molecular mechanisms, and long non-coding RNAs (lncRNAs) may participate in this process. However, the mechanism by which melatonin affects the function of lncRNAs in tri
Autor:
Weijun Liu, Weiyang Cai, Ying-Li Wu, Wenfu Tan, Jun Yang, Yu Zou, Yuan Liu, Qingqing Ding, Wenjing Huang, Yu Zhang, Juan Wang, Jing Gao, Hu Zhou, Zhang Yanjie, Pei hao Yin, Yanyan Qiu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal
Publikováno v:
Oncogene. 39:5867-5875
Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplan
Autor:
Frank Seeliger, Carla P. Martins, Emily James, Sandra Wimberger, Camilla Johansson, Mohammad Bohlooly-Y, Emma J. Davies, Maryam Clausen, Lukas Badertscher, Michelle J. Porritt, Simon T. Barry, Xiufeng Xu, Anna Schantz, Roberto Nitsch, Amir Taheri-Ghahfarokhi, Marcello Maresca, Himjyot Jaiswal, Elizabeth Hardaker, Jenna Bradley, Babak Alaeimahabadi, Lorenz M. Mayr, Abdel Wahad Bidar, Therese Admyre, Anders Lundin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still expensive and time-consuming, demanding more target flexibility and faster turnaround times
Autor:
Hui-Chuan Sun, Zhao-You Tang, Bin Xu, Yunfei Xu, Yuan-Yuan Zhang, Xiao-Dong Zhu, Kang-Shuai Li, Wen-Kai Shi, Ming Lei, Shi-Zhe Zhang, Man-Qing Cao, Xiao-Long Li, Hongda Liu, Xue-Feng Liu, Nan Xiao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage; however, the effect of systemic therapy on advanced HCC remains undetermined. Therefore, new treatment targets must be identified. We analyzed Gene Expression Omnibus da
Autor:
Michael A. Rogers, Behnoush Kermanshahi, Saeed M. Ghazani, Katrina Tait, Matthew Tcheng, Richard W. Smith, Shannon P. Callender, Paul A. Spagnuolo, Shawn D. Wettig, William Tam, Nawaz Ahmed, Alessia Roma, Alejandro G. Marangoni
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic modulators that selectively induce apoptosis of leukemia stem cells and reverse pathologies assoc
Autor:
Gerburg M. Wulf, Lin Ding, Hai Hu, Phei Er Saw, Jiewen Chen, Man-Li Luo, Yandan Yao, Herui Yao, Huangming Hong, Xiaorong Lin, Wenkui Fu, Zhuofei Bi, Tao Qin, Qingjian Li, Xiao-Ding Xu, Fang Zheng, Wei Wu, Erwei Song
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Resistance development to one chemotherapeutic reagent leads frequently to acquired tolerance to other compounds, limiting the therapeutic options for cancer treatment. Herein, we find that overexpression of Rac1 is associated with multi-drug resista
Autor:
Satoshi Fujii, Midori Iida, Junichi Yamamoto, Shumpei Tateno, Tetsufumi Suwa, Takumi Ito, Hiroshi Handa, Miki Katayama, Satoshi Sakamoto, Yuki Yamaguchi, Haruka Tokuyama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through CRBN, a component of the E3 ubiquitin ligase complex CRL4CRBN. To search for novel factors involved in the anti-cancer acti
Autor:
Gian Paolo Spinelli, Rosalba Caccavale, Carmela Martire, Ilenia Cammarata, Paolo Visca, Sheila Spada, Felice Giangaspero, Paola Nisticò, Silvia Piconese, Silverio Tomao, Chiara Focaccetti, Fabiana Letizia Cecere, Gabriella Girelli, Julio Rodrigo Giròn Berrìos, Flavia Longo, Federica Buzzacchino, Carmine Mancone, Marino Paroli, Giovanna Peruzzi, Vincenzo Barnaba, Marta Buccilli, Mariangela Panetta, Alessio Grimaldi, Nicoletta D'Alessandris, Francesco Facciolo
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Here, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with th
Autor:
Caijun Zha, Yang Liu, Pengfei Wu, Yu Zhao, Tengfei Qi, Chuanlu Jiang, Bo Han, Xiangqi Meng, Ziwei Li, Jinquan Cai, Yangong Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Activation of receptor tyrosine kinase (RTK) protein is frequently observed in malignant progression of gliomas. In this study, the crosstalk activation of epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) sig