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Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Ribosomes stalled during translation must be rescued to replenish the pool of translation-competent ribosomal subunits. Bacterial alternative rescue factor B (ArfB) releases nascent peptides from ribosomes stalled on mRNAs truncated at the A site, al
Autor:
Jonathan S. Abebe, Alexa B. R. McIntyre, Matthew D. Weitzman, Alexander M. Price, Nandan S. Gokhale, Christopher E. Mason, Daniel P. Depledge, Ashley N. Della Fera, Katharina E. Hayer, Stacy M. Horner, Angus C. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery. Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes the addition of N6-methyladenosine (m6A) to mRNAs. While m6A-modified adeno
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Membrane-less organelles or compartments are considered to be dynamic reaction centers for spatiotemporal control of diverse cellular processes in eukaryotic cells. Although their formation mechanisms have been steadily elucidated via the classical c
Autor:
João Mello-Vieira, Maria M. Mota, Vanessa Zuzarte-Luis, Tania F. de Koning-Ward, Francisco J. Enguita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Autor:
Ashutosh Tripathy, Deepa Ajit, Natallia V. Riddick, John Q. Trojanowski, Michelle S. Itano, Sheryl S. Moy, Hanna Trzeciakiewicz, Todd J. Cohen, Zarin Tabassum, Youjun Chen, Claire Peterson, Rebecca Lobrovich, Jui-Heng Tseng, Aditi Ajit, Virginia M.-Y. Lee, David J. Irwin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates ta
Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
Autor:
Christiaan de Leeuw, Martijn P. van den Heuvel, Philip R. Jansen, Yongbin Wei, Danielle Posthuma, Mats Nagel, Jeanne E. Savage, Sophie van der Sluis, Kyoko Watanabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1):5606
Nature Communications
Jansen, P R, Nagel, M, Watanabe, K, Wei, Y, Savage, J E, de Leeuw, C A, van den Heuvel, M P, van der Sluis, S & Posthuma, D 2020, ' Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence ', Nature Communications, vol. 11, no. 1, 5606 . https://doi.org/10.1038/s41467-020-19378-5
Nature Communications, 11:5606, 1-12. Nature Publishing Group
Jansen, P R, Nagel, M, Watanabe, K, Wei, Y, Savage, J E, de Leeuw, C A, van den Heuvel, M P, van der Sluis, S & Posthuma, D 2020, ' Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence ', Nature Communications, vol. 11, 5606, pp. 1-12 . https://doi.org/10.1038/s41467-020-19378-5
Nature Communications, 11(1):5606
Nature Communications
Jansen, P R, Nagel, M, Watanabe, K, Wei, Y, Savage, J E, de Leeuw, C A, van den Heuvel, M P, van der Sluis, S & Posthuma, D 2020, ' Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence ', Nature Communications, vol. 11, no. 1, 5606 . https://doi.org/10.1038/s41467-020-19378-5
Nature Communications, 11:5606, 1-12. Nature Publishing Group
Jansen, P R, Nagel, M, Watanabe, K, Wei, Y, Savage, J E, de Leeuw, C A, van den Heuvel, M P, van der Sluis, S & Posthuma, D 2020, ' Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence ', Nature Communications, vol. 11, 5606, pp. 1-12 . https://doi.org/10.1038/s41467-020-19378-5
The phenotypic correlation between human intelligence and brain volume (BV) is considerable (r ≈ 0.40), and has been shown to be due to shared genetic factors. To further examine specific genetic factors driving this correlation, we present genomic
Autor:
Risako Nakano, Aisha Yesbolatova, Yumiko Saga, Kosuke Fukui, Yuichiro Saito, Ken-ichiro Hayashi, Hirofumi Nakaoka, Kanae Gamo, Rieko Ajima, Naomi Kitamoto, Yusuke Tominari, Hatsune Makino-Itou, Masato T. Kanemaki, Haruki Takeuchi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Protein knockdown using the auxin-inducible degron (AID) technology is useful to study protein function in living cells because it induces rapid depletion, which makes it possible to observe an immediate phenotype. However, the current AID system has
Autor:
Nikunj Sharma, David R Sweet, Panjamaporn Sangwung, Yoichi Takami, Neelakantan T Vasudevan, Anthony Wynshaw-Boris, Paul Holvoet, Yuan Lu, Liyan Fan, Xudong Liao, Stanton L. Gerson, E. Ricky Chan, Chen Fu, Chloe E Booth, Vinesh Vinayachandran, Guangjin Zhou, Lilei Zhang, Keiichiro Matoba, Yulan Qing, Komal S Keerthy, Mukesh K. Jain, Lalitha Nayak, Derin Tugal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Substantial evidence implicates crosstalk between metabolic tissues and the immune system in the inception and progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally and peripherally remains incompletely
Autor:
Henrik Nielsen, Yuan Mang, Canan Doganli, Louise Lindbæk, Nicolai Krogh, André Brás Gonçalves, Lars Allan Larsen, Kjeld Møllgård, Søren T. Christensen, Shahid Mahmood Baig, Muhammad Farooq, Jay Gopalakrishnan, Hans Eiberg, Maren Mönnich, Lars Hansen, Niels Tommerup, Lotte B. Pedersen, Vivi Søgaard Andersen, Cecilie Keller, Ambrin Fatima, Muhammad Sajid Hussain, Srinivasan Sakthivel, Klaus W. Kjaer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Farooq, M, Lindbæk, L, Krogh, N, Doganli, C, Keller, C, Mönnich, M, Gonçalves, A B, Sakthivel, S, Mang, Y, Fatima, A, Andersen, V S, Hussain, M S, Eiberg, H, Hansen, L, Kjaer, K W, Gopalakrishnan, J, Pedersen, L B, Møllgård, K, Nielsen, H, Baig, S M, Tommerup, N, Christensen, S T & Larsen, L A 2020, ' RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis ', Nature Communications, vol. 11, 5816 . https://doi.org/10.1038/s41467-020-19658-0
Nature Communications
Farooq, M, Lindbæk, L, Krogh, N, Doganli, C, Keller, C, Mönnich, M, Gonçalves, A B, Sakthivel, S, Mang, Y, Fatima, A, Andersen, V S, Hussain, M S, Eiberg, H, Hansen, L, Kjaer, K W, Gopalakrishnan, J, Pedersen, L B, Møllgård, K, Nielsen, H, Baig, S M, Tommerup, N, Christensen, S T & Larsen, L A 2020, ' RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis ', Nature Communications, vol. 11, 5816 . https://doi.org/10.1038/s41467-020-19658-0
Nature Communications
Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual disability. The exact pathophysiological mechanism underlying MCPH remains to be elucidated, but dysfunction of neuronal progenitors in the developing neocortex plays
Autor:
Inkyu Lee, Habibur Rahman, Jae-Hong Kim, Il-Sung Jang, Kyoungho Suk, Mithilesh Kumar Jha, Younghoon Go, Anup Bhusal, Gyun Jee Song
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Hypothalamic inflammation plays an important role in disrupting feeding behavior and energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show that pyruvate dehydrogenase kinase (PDK)-2 plays a role in hypothalamic infl