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Autor:
Yusuke Murakami, Takashi Ishii, Keigo Kurata, Hiroki Nunokawa, Naomi Yamashita, Tomoya Narita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Allergic asthma is one of most famous allergic diseases, which develops lung and airway inflammation. Recent studies have revealed the relationship between the pathology of allergic asthma and the increase of host-derived DNA in inflamed lung, but th
Autor:
Pedro J. Sánchez-Cordón, John Spiropoulos, Daryan A. Kaveh, Philip J. Hogarth, M. Carmen Garcia-Pelayo, Naomi Bull
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Heterologous BCG prime-boost regimens represent a promising strategy for an urgently required improved tuberculosis vaccine. Identifying the mechanisms which underpin the enhanced protection induced by such strategies is one key aim which would signi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Bovine tuberculosis (bTB), a zoonosis mainly caused by Mycobacterium bovis has severe socio-economic consequences and impact on animal health. Host–pathogen interactions during M. bovis infection are poorly understood, especially early events which
Autor:
Ashley J. Snider, Yusuf A. Hannun, Rasheed Ahmad, Zunair Ahmad, Motasem Melhem, Fahd Al-Mulla, Fatema Al-Rashed, Lina M. Obeid, Reeby Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Obesity is associated with elevated levels of TNF-α and proinflammatory CD11c monocytes /macrophages. TNF-α mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, includi
Autor:
Ilke De Boeck, Cristina García-Timermans, Tom Van de Wiele, Charlotte De Rudder, Sarah Lebeer, Marta Calatayud Arroyo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
SCIENTIFIC REPORTS
Scientific reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
SCIENTIFIC REPORTS
Live biotherapeutic products (LBP) are emerging as alternative treatment strategies for chronic rhinosinusitis. The selection of interesting candidate LBPs often involves model systems that do not include the polymicrobial background (i.e. the host m
Autor:
Alireza Faridar, Shixiang Wen, Jason R. Thonhoff, Aaron D. Thome, David R. Beers, Weihua Zhao, Jinghong Wang, Daniel Neal, Stanley H. Appel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder compromising muscle function resulting in death. Neuroinflammation is known to accelerate disease progression and accentuate disease severity
Autor:
Zijie Yuan, Youde Cao, Yonghua Yuan, Zhonghua Deng, Yanghua Yue, Jie Chen, Lu Wang, Menghua Zhao, Chaochao Tan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Kawasaki disease (KD) is a multi-systemic vasculitis of unknown etiology that occurs mainly in children, and the disturbance of gut microbiota is generally believed to cause a hyperimmune reaction triggering KD. The aim of the study was to investigat
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
There are a number of respiratory diseases characterized by the presence of excess neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chronic obstructive pulmonary disease (COPD). NE is considered a primary contributor to dis
Autor:
Larissa M. N. Pereira, Katherine A. Fitzgerald, Caroline Junqueira, Patricia A. Assis, Ricardo T. Gazzinelli, Dario S. Zamboni, Dhelio Batista Pereira, Natalia M. de Araujo, Danielle Fernandes Durso, Egil Lien, Douglas T. Golenbock, Marco Antonio Ataide
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Pl
Autor:
Christine A. Butts, Shanthi G. Parkar, Matthew R. Perrott, Kerry L. Bentley-Hewitt, Duncan Hedderley, Halina Stoklosinski
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Kiwifruit (KF) contains bioactive compounds with potential anti-inflammatory properties. In this study, we investigated the protective effects of KF on gastric and duodenal damage induced by soluble aspirin in healthy rats. Sixty-four male Sprague Da