Zobrazeno 1 - 10
of 70
pro vyhledávání: ''
Autor:
Nikunj Sharma, David R Sweet, Panjamaporn Sangwung, Yoichi Takami, Neelakantan T Vasudevan, Anthony Wynshaw-Boris, Paul Holvoet, Yuan Lu, Liyan Fan, Xudong Liao, Stanton L. Gerson, E. Ricky Chan, Chen Fu, Chloe E Booth, Vinesh Vinayachandran, Guangjin Zhou, Lilei Zhang, Keiichiro Matoba, Yulan Qing, Komal S Keerthy, Mukesh K. Jain, Lalitha Nayak, Derin Tugal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Substantial evidence implicates crosstalk between metabolic tissues and the immune system in the inception and progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally and peripherally remains incompletely
Autor:
Inkyu Lee, Habibur Rahman, Jae-Hong Kim, Il-Sung Jang, Kyoungho Suk, Mithilesh Kumar Jha, Younghoon Go, Anup Bhusal, Gyun Jee Song
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Hypothalamic inflammation plays an important role in disrupting feeding behavior and energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show that pyruvate dehydrogenase kinase (PDK)-2 plays a role in hypothalamic infl
Autor:
Xian J. Lian, Amr Omer, Imed-Eddine Gallouzi, Sergio Di Marco, Julian Lucas Moran, Monica Cruz Barrera, Christian Beauséjour
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its
Autor:
Darren Roblyer, Yanyu Zhao, John P. Dumas, Mark C. Pierce, Hannah M. Peterson, Jon C. Aster, Anahita Pilvar, John Jiang, Anup Tank
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Water and lipids are key participants in many biological processes, but there are few non-invasive methods that provide quantification of these components in vivo, and none that can isolate and quantify lipids in the blood. Here we develop a new imag
Autor:
Yijian Li, Xiangfeng Liu, Guangdi Li, Huiling Li, Jian Pan, Bohao Liu, Yunchang Yuan, Xiaozhou Li, Peilin Zheng, Xudong Xiang, Xiangping Chai, Zhengyu Peng, Zhibiao He, Feng Liu, Hongliang Zhang, Dongshan Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation of proximal tubular DsbA-L for renal tubuloint
Autor:
Larissa M. N. Pereira, Katherine A. Fitzgerald, Caroline Junqueira, Patricia A. Assis, Ricardo T. Gazzinelli, Dario S. Zamboni, Dhelio Batista Pereira, Natalia M. de Araujo, Danielle Fernandes Durso, Egil Lien, Douglas T. Golenbock, Marco Antonio Ataide
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Pl
Autor:
Nian Liu, Pingping Zhu, Yong Tian, Liuliu Yang, Zusen Fan, Buqing Ye, L.L. He, H.B. Li, Benyu Liu, Tiankun Lu, Xiaoxiao Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is
Autor:
Asaf Spiegel, Hassan Massalha, Shalev Itzkovitz, Orit Kollet, Eman Khatib-Massalha, Isabell Brandenburger, Suditi Bhattacharya, Francesca Avemaria, Ronen Alon, Ziv Shulman, Zachary Gerhart-Hines, Amiram Ariel, Tsvee Lapidot, Tomer Itkin, Adi Biram, Karin Golan, Ekaterina Petrovich-Kopitman, Anju Kumari, Stefan Offermanns, Matthias Gunzer, Shiri Gur-Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neut
Autor:
Charlotte Hansen, Marcus Altfeld, Claudia Marggraff, Jill Noll, Stefan Hoenow, Iris Bruchhaus, Nahla Galal Metwally, Marie Weskamm, Marie Groneberg, Christoph Dorn, Stephanie Stanelle-Bertram, Svenja Kuehl, Harald Ittrich, Thomas Jacobs, Sven Hendrik Hagen, Julie Sellau, Egbert Tannich, Julia Wernecke, Vincent Wolf, Helena Fehling, Thorsten Thye, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of
Autor:
Matthew Sermersheim, Adam D. Kenney, Kristyn Gumpper, Jacob S. Yount, Ki Ho Park, Haichang Li, Jianjie Ma, Pei-Hui Lin, Temet M. McMichael, Xinyu Zhou, T. M. Ayodele Adesanya, Chuanxi Cai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific TRIM protein. Here we show human macrophages express MG53, and MG53