Zobrazeno 1 - 10
of 535
pro vyhledávání: ''
Autor:
David C. Page, Alan J. Gow, Ian J. Deary, Olivia K.L. Hamilton, M. del C. Valdés-Hernández, Paul Redmond, Simon R. Cox, Joanna M. Wardlaw, Adele M. Taylor, Lucia Ballerini, Janie Corley, Mark E. Bastin, S. Muñoz Maniega, F. Conte, Judith A. Okely
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD’s association with slowed processing might be due to its association with overall declining gen
Autor:
Xiangbin Pan, Yao-Hua Song, Yu Zhang, Yangxin Li, Xi-Yong Yu, Zhenya Shen, Bin Liu, Hui Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals. Inflammasome multiprotein complexes are composed of three parts: a sensor protein, an a
Autor:
Mengyuan Niu, Li Li, Yibing Ding, Lulu Wei, Wangsen Cao, Wenyuan Pu, Zhonglan Su, Shiyu Song, Qian Gao, Hongwei Wang, Chen Zhao, Junaid Wazir
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly impairs the quality of life of cancer patients; however, the underlying pathological proc
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric s
Autor:
Silvia Guerrera, Melania Manco, Silvia Di Vara, Lucilla Ravà, Stefano Vicari, Marta Ciofi Degli Atti, Giovanni Valeri
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
The autism spectrum disorder (ASD) is an etiologically heterogeneous disorder. Dysfunctions of the intermediate metabolism have been described in some patients. We speculate these metabolic abnormalities are associated with brain insulin resistance (
Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
Funder: Stanley Medical Research Institute (SMRI); doi: https://doi.org/10.13039/100007123
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Autor:
Markus J. Hofer, Samantha J. Lain, Velda X. Han, Natasha Nassar, Shekeeb S. Mohammad, Hannah F Jones, Russell C. Dale, Wendy A. Gold, Shrujna Patel, Timothy C Nielsen, Fabienne Brilot
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), trigge
Autor:
Kritika Subramanian, Selin Merdan, Turgay Ayer, Johan Van Weyenbergh, Jean L. Koff, Christopher R. Flowers, Andres Chang
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 1, Pp 1-12 (2021)
Blood Cancer Journal
Blood Cancer Journal
The clinical risk stratification of diffuse large B-cell lymphoma (DLBCL) relies on the International Prognostic Index (IPI) for the identification of high-risk disease. Recent studies suggest that the immune microenvironment plays a role in treatmen
Autor:
Tim S. Heistek, Sara Hijazi, Philip Scheltens, Derya R. Shimshek, August B. Smit, Ulf Neumann, Ronald E. van Kesteren, Huibert D. Mansvelder
Publikováno v:
Molecular Psychiatry, 25(12), 3380-3398. Nature Publishing Group
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibi