Zobrazeno 241 - 250
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Autor:
Steven Clarke, Michael Michael, Zhangkai Jason Cheng, Fatemeh Vafaee, Connie I. Diakos, Lisa G. Horvath, Zdenka Kuncic, Michaela B. Kirschner, Hamid Alinejad-Rokny, Glen Reid
Publikováno v:
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-12 (2018)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Recent advances in high-throughput technologies have provided an unprecedented opportunity to identify molecular markers of disease processes. This plethora of complex-omics data has simultaneously complicated the problem of extracting meaningful mol
Autor:
Gilaad G. Kaplan, Troy Perry, Masoumeh Sikaroodi, Karen L. Madsen, Heekuk Park, Bryan Dicken, Karen I. Kroeker, Patrick M. Gillevet, Michael Laffin, Richard N. Fedorak, Levinus A. Dieleman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Crohn’s disease (CD) patients who undergo ileocolonic resection (ICR) typically have disease recurrence at the anastomosis which has been linked with a gut dysbiosis. The aims of this study were to define the mucosa-associated microbiota at the tim
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Corpora amylacea (CA) are spherical bodies mainly composed of polyglucans and, to a lesser extent, proteins. They are abundant in brains from patients with neurodegenerative diseases, particularly Alzheimer's disease. Although CA were discovered many
Autor:
Melissa A. Troester, Charles M. Perou, Joseph Geradts, Katherine A. Hoadley, Lindsay A. Williams, Ashley M. Fuller, Emma H. Allott, Eboneé N. Butler, Stephanie M. Cohen, Xuezheng Sun, Andrew F. Olshan
Publikováno v:
npj Breast Cancer, Vol 4, Iss 1, Pp 1-6 (2018)
NPJ Breast Cancer
Williams, L A, Butler, E N, Sun, X, Allott, E H, Cohen, S M, Fuller, A M, Hoadley, K A, Perou, C M, Geradts, J, Olshan, A F & Troester, M A 2018, ' TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases ', npj Breast Cancer, vol. 25, no. 4, 13 . https://doi.org/10.1038/s41523-018-0067-5
NPJ Breast Cancer
Williams, L A, Butler, E N, Sun, X, Allott, E H, Cohen, S M, Fuller, A M, Hoadley, K A, Perou, C M, Geradts, J, Olshan, A F & Troester, M A 2018, ' TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases ', npj Breast Cancer, vol. 25, no. 4, 13 . https://doi.org/10.1038/s41523-018-0067-5
Mutations in tumor suppressor TP53 have been inconsistently linked to breast cancer risk factors and survival. Immunohistochemistry (IHC) staining, a primary clinical means of TP53 mutation determination, only detects mutations that facilitate protei
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a syst
Autor:
Shinichiro Hayashi, Madoka Mori-Yoshimura, Ichizo Nishino, Hirokazu Shiraishi, Satoru Noguchi, Shunsuke Yoshimura, Akira Tsujino, Michio Inoue, Yukiko K. Hayashi, Ikuya Nonaka, Yuji Takahashi, Aritoshi Iida, Atsushi Nagaoka
Publikováno v:
Human Genome Variation, Vol 5, Iss 1, Pp 1-5 (2018)
Human Genome Variation
Human Genome Variation
VCP mutations were first associated with inclusion body myopathy with Paget’s disease of bone and frontotemporal dementia (IBMPFD) but was later associated with amyotrophic lateral sclerosis and Charcot–Marie–Tooth disease. Now, a new name, “
Autor:
Alexandre Prat, Yousra Khalfallah, Camille Grasmuck, Rachel Kuta, Christine Vande Velde, Heather D. Durham
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Stress granules (SGs) are cytoplasmic foci that form in response to various external stimuli and are essential to cell survival following stress. SGs are studied in several diseases, including ALS and FTD, which involve the degeneration of motor and
Autor:
Zhiwen Zhou, Xudong Mao, Qihong Cheng, Bin Hu, Jing Gao, Qing Gong, Yan Wu, Yue He, Xubin Xing, Ying Hu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Hypovitaminosis D is associated with age-related illnesses, including hypertension, cardiovascular disease (CRVD), cerebrovascular disease (CAD) and type 2 diabetes mellitus (T2DM). In our retrospective observational study, blood samples of elderly h
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory responses and is upregulated during sepsis and pulmonary infection. The association between serum soluble TREM-1 (sTREM-1) level and pulmonary tuberculosis (PTB) disease
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Translational Psychiatry
Translational Psychiatry
Genetic components susceptible to complex disease such as schizophrenia include a wide spectrum of variants, including common variants (CVs) and de novo mutations (DNMs). Although CVs and DNMs differ by origin, it remains elusive whether and how they