Zobrazeno 31 - 40
of 535
pro vyhledávání: ''
Autor:
Sin-Hyeog Im, John Chulhoon Park
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1383-1396 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Considerable evidence points to the critical role of the gut microbiota in physiology and disease. The administration of live microbes as a therapeutic modality is increasingly being considered. However, key questions such as how to identify candidat
Autor:
Edwin J C van der Schans, Steven E. Pierce, Jordan Prahl, Trevor A. Tyson, Alix Booms, Gerhard A. Coetzee
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-5 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
Genetic risk for complex diseases very rarely reflects only Mendelian-inherited phenotypes where single-gene mutations can be followed in families by linkage analysis. More commonly, a large set of low-penetrance, small effect-size variants combine t
Autor:
Alireza Faridar, Shixiang Wen, Jason R. Thonhoff, Aaron D. Thome, David R. Beers, Weihua Zhao, Jinghong Wang, Daniel Neal, Stanley H. Appel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder compromising muscle function resulting in death. Neuroinflammation is known to accelerate disease progression and accentuate disease severity
Autor:
Bin Zhang, Jian Q. Feng, Nan Su, Zhenhong Ni, Yangli Xie, Min Jin, Lin Chen, Xianding Sun, Shuo Huang, Dali Zhang, Hangang Chen, Jing Yang, Fengtao Luo, Huabing Qi, Qiaoyan Tan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-38 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation,
Autor:
Jinho Yang, Ju Kwang Choi, Yoon Jeong Park, Da Hyeon Choi, Jae Won Chang, Bon Seok Koo, Yoon Shin Park, Ho-Ryun Won, Won Hee Lee, Jiwon Park, Chan Oh, Ju Yeon Lee, Kyeong Eun Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1564-1573 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and re
Autor:
Maria Gavriatopoulou, Lia-Angela Moulopoulos, Evangelos Terpos, Nikolaos Kanellias, Andriani Βoultadaki, Efstathios Kastritis, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Magdalini Migkou, Charis Bourgioti, Despina Fotiou, Meletios A. Dimopoulos, Evangelos Eleutherakis-Papaiakovou, Vassilis Koutoulidis
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 9, Pp 1-7 (2020)
Blood Cancer Journal
Blood Cancer Journal
Introduction: Multiple myeloma (MM) is the second most common haematological malignancy and is characterized by bone marrow infiltration of monoclonal plasma cells and end-organ involvement. Smoldering MM (SMM) is an intermediate clinical entity betw
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
The akinetic/rigid (AR) motor subtype of Parkinson’s Disease is associated with increased rates of motor and cognitive decline. Cross-sectional studies examining the neural correlates of AR have found abnormalities in both subcortical and cortical
Autor:
Cecilie L. Bager, M. H. Tang, Anne-Christine Bay-Jensen, Søren Brunak, P. Frederiksen, Morten A. Karsdal, Joseph P.M. Blair
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Blair, J P M, Bay-Jensen, A-C, Tang, M H, Frederiksen, P, Bager, C, Karsdal, M & Brunak, S 2020, ' Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis ', Scientific Reports, vol. 10, no. 1, 13975 . https://doi.org/10.1038/s41598-020-70942-x
Scientific Reports
Blair, J P M, Bay-Jensen, A-C, Tang, M H, Frederiksen, P, Bager, C, Karsdal, M & Brunak, S 2020, ' Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis ', Scientific Reports, vol. 10, no. 1, 13975 . https://doi.org/10.1038/s41598-020-70942-x
Rheumatoid arthritis (RA) is a chronic inflammatory disease with fluctuating course of progression. Despite substantial improvement in treatments in recent years, treatment response is still not guaranteed. The aim of this study was to identify varia
Autor:
Yaqian Xu, Ashley S. Harms, Anna S. Nordvig, Luigi Zecca, James E. Goldman, K. Ray Chaudhuri, Elena Moro, Valentina Leta, Alessandro Sette, Stanley Fahn, Osama Al-Dalahmah, Richard J. Smeyne, David Sulzer, Olimpia Meucci, Angelo Antonini, Luigi Bubacco
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-10 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s diseas