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Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
In heterozygous genomes, allele-specific measurements can reveal biologically significant differences in DNA methylation between homologous alleles associated with local changes in genetic sequence. Current approaches for detecting such events from w
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Liu, Q, Pan, J, Berzuini, C, Rutter, M K & Guo, H 2020, ' Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes ', Scientific Reports, vol. 10, no. 1 . https://doi.org/10.1038/s41598-020-64493-4
Scientific Reports
Liu, Q, Pan, J, Berzuini, C, Rutter, M K & Guo, H 2020, ' Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes ', Scientific Reports, vol. 10, no. 1 . https://doi.org/10.1038/s41598-020-64493-4
Scientific Reports
Genome-wide association studies have identified hundreds of single nucleotide polymorphisms (SNPs) that are associated with BMI and diabetes. However, lack of adequate data has for long time prevented investigations on the pathogenesis of diabetes wh
Autor:
Charleen D. Adams
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Education and intelligence are highly correlated and inversely associated with schizophrenia. Counterintuitively, education genetically associates with an increased risk for the disease. To investigate why, this study applies a multivariable Mendelia
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry
Translational Psychiatry
Patients with late-onset Alzheimer’s disease (LOAD) frequently manifest comorbid neuropsychiatric symptoms with depression and anxiety being most frequent, and individuals with major depressive disorder (MDD) have an increased prevalence of LOAD. T
Autor:
Kathleen M. Loomes, Ramakrishnan Rajagopalan, Nancy B. Spinner, Marcella Devoto, Susan Kelly, Christopher M. Grochowski, Ellen A. Tsai
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Biliary atresia (BA) is a severe pediatric liver disease resulting in necroinflammatory obliteration of the extrahepatic biliary tree. BA presents within the first few months of life as either an isolated finding or with additional syndromic features
Autor:
Yoonsu Cho, Jie Zheng, Tom R. Gaunt, Andrew P. Morris, George Davey Smith, Eleanor Sanderson, Philip C Haycock, Gibran Hemani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, no. 1, 1010, pp. 1010 . https://doi.org/10.1038/s41467-020-14452-4
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, 1010 (2020) . https://doi.org/10.1038/s41467-020-14452-4
Nature Communications
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, no. 1, 1010, pp. 1010 . https://doi.org/10.1038/s41467-020-14452-4
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, 1010 (2020) . https://doi.org/10.1038/s41467-020-14452-4
In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX,
Autor:
Lina-Marcela Diaz-Gallo, Tomoko Iseda, Lars Alfredsson, Susanna Kullberg, Camilla Bengtsson, Leonid Padyukov, Karina Patasova, Ingrid Kockum, Natalia V. Rivera, Johan Grunewald, Anders Eklund
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren’s
Autor:
Gene-Siew Ngian, Ali Bayoumi, Khaled Thabet, Lorenzo Beretta, Wendy Stevens, Nicholas Manolios, Kathleen Tymms, Susanna Proudman, Jane Zochling, Jacob George, Janet Roddy, Maureen Rischmueller, Mayada Metwally, Gemma Strickland, Susan C. Lester, Olfat G. Shaker, Pravin Hissaria, Mohammed Eslam, Mandana Nikpour, Christopher Liddle, Joanne Sahhar, Jennifer G Walker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-5 (2019)
Scientific Reports
Scientific Reports
Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene (IFNL3) was shown to be associated with fibrosis in liver across
Autor:
Wen Wang, Chad L. Myers, Nathan Pankratz, Michael Steinbach, Gang Fang, Michael Costanzo, Vipin Kumar, Xiaotong Liu, Hamed Heydari, Eric E. Schadt, Benjamin VanderSluis, Benjamin Oately, Xiaoye Liu, Vanja Paunic, Brian G Van Ness, Charles Boone
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Genetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans remains unclear. In principle, genome-wide association studies (GWAS) provide a platform for
Autor:
Sabine Matou-Nasri, Hamad I. Al-Ashgar, Jahad Alghamdi, Khalid Alswat, Ahmed A. Al-Qahtani, Waleed Al-Hamoudi, Arwa A. Al-Qahtani, Mashael R. Al-Anazi, Mohammed Q. Khan, Marie Fe F. Bohol, Monis Bilal Shamsi, Ayman A. Abdo, Mohammed N. Al-Ahdal, Salah K. Alanazi, Faisal M. Sanai, Ali Albenmousa, Damian M. Dela Cruz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Interleukin-37 (IL-37) has recently been recognized as a strong anti-inflammatory cytokine having anti-tumor activity against hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients. HCC is a typical inflammation-related cancer, a