Zobrazeno 21 - 30
of 51
pro vyhledávání: ''
Autor:
González-Serna, David, Ochoa, Eguzkine, López-Isac, Elena, Julià, Antonio, Degenhardt, Frauke, Ortego-Centeno, Norberto, Radstake, Timothy R.D.J., Franke, Andre, Marsal, Sara, Mayes, Maureen D., Martín, Javier, Márquez, Ana, Assassi, Shervin, Zhou, Xiaodong, Tan, Filemon K., Arnett, Frank C., Reveille, John D., Gorlova, Olga, Chen, Wei V., Ying, Jun, Gregersen, Peter K., Lee, Annette T., Voskuyl, Alexandre E., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Broen, Jasper, Koeleman, Bobby P.C., Simeón, Carmen P., Fonollosa, Vicente, Guillén, Alfredo, Carreira, Patricia, Castellví, Iván, González-Gay, Miguel A., Ríos, Raquel, Callejas-Rubio, Jose Luis, Vargas-Hitos, José A., García-Portales, Rosa, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Aguirre, Ma Ángeles, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, de la Peña, Paloma García, Vicente, Esther, Andreu, José Luis, Fernández de Castro, Mónica, López-Longo, Francisco Javier, Martínez, Lina, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Rodríguez-Carballeira, Mónica, Narváez, Francisco Javier, Rubio-Rivas, Manel, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Fanlo-Mateo, Patricia, Sáez-Comet, Luis, Díaz-González, Federico, Hernández, Vanesa, Beltrán, Emma, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco-García, Francisco J., Oreiro, Natividad, Freire, Mayka, Balsa, Alejandro, Ortiz, Ana M., Hunzelmann, Nicolas, Riemekasten, Gabriela, Distler, Jörg H.W., Witte, Torsten, Airó, Paolo, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando
Publikováno v:
Scientific Reports, 10(1):1862. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
González-Serna, D, Ochoa, E, López-Isac, E, Julià, A, Degenhardt, F, Ortego-Centeno, N, Radstake, T R D J, Franke, A, Marsal, S, Mayes, M D, Martín, J, Márquez, A, Assassi, S, Zhou, X, Tan, F K, Arnett, F C, Reveille, J D, Gorlova, O, Chen, W V, Ying, J, Gregersen, P K, Lee, A T, Voskuyl, A E, de Vries-Bouwstra, J, Magro-Checa, C, Broen, J, Koeleman, B P C, Simeón, C P, Fonollosa, V, Guillén, A, Carreira, P, Castellví, I, González-Gay, M A, Ríos, R, Callejas-Rubio, J L, Vargas-Hitos, J A, García-Portales, R, Camps, M T, Fernández-Nebro, A, González-Escribano, M F, García-Hernández, F J, Castillo, M J, Aguirre, M Á, Gómez-Gracia, I, Rodríguez-Rodríguez, L, Fernández-Gutiérrez, B, de la Peña, P G, Vicente, E, Andreu, J L, Fernández de Castro, M, López-Longo, F J, Martínez, L, Espinosa, G, Tolosa, C, Pros, A, Rodríguez-Carballeira, M, Narváez, F J, Rubio-Rivas, M, Ortiz-Santamaría, V, Madroñero, A B, Díaz, B, Trapiella, L, Sousa, A, Egurbide, M V, Fanlo-Mateo, P, Sáez-Comet, L, Díaz-González, F, Hernández, V, Beltrán, E, Román-Ivorra, J A, Grau, E, Alegre-Sancho, J J, Blanco-García, F J, Oreiro, N, Freire, M, Balsa, A, Ortiz, A M, Hunzelmann, N, Riemekasten, G, Distler, J H W, Witte, T, Airó, P, Beretta, L, Santaniello, A, Bellocchi, C, Lunardi, C, Moroncini, G, Gabrielli, A & Scleroderma Genetic Consortium 2020, ' A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease ', Scientific Reports, vol. 10, no. 1, 1862 . https://doi.org/10.1038/s41598-020-58741-w
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digibug. Repositorio Institucional de la Universidad de Granada
Scientific Reports
Scientific Reports (2020) 10:1862
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
González-Serna, D, Ochoa, E, López-Isac, E, Julià, A, Degenhardt, F, Ortego-Centeno, N, Radstake, T R D J, Franke, A, Marsal, S, Mayes, M D, Martín, J, Márquez, A, Assassi, S, Zhou, X, Tan, F K, Arnett, F C, Reveille, J D, Gorlova, O, Chen, W V, Ying, J, Gregersen, P K, Lee, A T, Voskuyl, A E, de Vries-Bouwstra, J, Magro-Checa, C, Broen, J, Koeleman, B P C, Simeón, C P, Fonollosa, V, Guillén, A, Carreira, P, Castellví, I, González-Gay, M A, Ríos, R, Callejas-Rubio, J L, Vargas-Hitos, J A, García-Portales, R, Camps, M T, Fernández-Nebro, A, González-Escribano, M F, García-Hernández, F J, Castillo, M J, Aguirre, M Á, Gómez-Gracia, I, Rodríguez-Rodríguez, L, Fernández-Gutiérrez, B, de la Peña, P G, Vicente, E, Andreu, J L, Fernández de Castro, M, López-Longo, F J, Martínez, L, Espinosa, G, Tolosa, C, Pros, A, Rodríguez-Carballeira, M, Narváez, F J, Rubio-Rivas, M, Ortiz-Santamaría, V, Madroñero, A B, Díaz, B, Trapiella, L, Sousa, A, Egurbide, M V, Fanlo-Mateo, P, Sáez-Comet, L, Díaz-González, F, Hernández, V, Beltrán, E, Román-Ivorra, J A, Grau, E, Alegre-Sancho, J J, Blanco-García, F J, Oreiro, N, Freire, M, Balsa, A, Ortiz, A M, Hunzelmann, N, Riemekasten, G, Distler, J H W, Witte, T, Airó, P, Beretta, L, Santaniello, A, Bellocchi, C, Lunardi, C, Moroncini, G, Gabrielli, A & Scleroderma Genetic Consortium 2020, ' A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease ', Scientific Reports, vol. 10, no. 1, 1862 . https://doi.org/10.1038/s41598-020-58741-w
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digibug. Repositorio Institucional de la Universidad de Granada
Scientific Reports
Scientific Reports (2020) 10:1862
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
We thank Sofia Vargas and Gema Robledo for her excellent technical assistance and all the patients and control donors for their essential collaboration. We thank WTCCC (Welcome Trust Case Control Consortium) for the access to GWAS data of Crohn’s d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d69d378d77c8af11b3972155f91244c
http://hdl.handle.net/10261/222176
http://hdl.handle.net/10261/222176
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-5 (2018)
Scientific Reports
Scientific Reports
Vitiligo is a skin disease that affects 1% of the population worldwide. Both environmental and genetic factors contribute to the risk of vitiligo. GZMB encodes the enzyme Granzyme B, which plays an important role in cytotoxic T cell-induced apoptosis
Autor:
Kyudong Han, Hak-Min Kim, Hyunho Kim, Je Hoon Jun, Yun Sung Cho, Chang Geun Kim, Yumi Kim, Jung-Eun Kim, Jeremy S. Edwards, Semin Lee, Jong Bhak, Hye Jin Lee, In Song Koh, Kyun Shik Chae, Byungchul Kim, Jessica A. Weber, Sungwoong Jho, Ok Sung Chung, Jinho Jang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants. We r
Autor:
Daniele Pastori, Anna Montali, Bruna De Masi, Alessia Di Costanzo, Marialuisa Sponziello, Diego Bailetti, Francesco Angelico, Laura D'Erasmo, Francesca Belardinilli, Licia Polimeni, Francesco Baratta, Giuseppe Giannini, Fabrizio Ceci, Gabriella Girelli, Antonio Angeloni, Maria Del Ben, Marcello Arca
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 gen
Autor:
Jarmo Ritari, Kati Hyvärinen, Satu Koskela, David Gallardo, Riitta Niittyvuopio, Jukka Partanen, Liisa Volin, Anne Nihtinen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Despite detailed human leukocyte antigen (HLA) matching and modern immunosuppressive therapy, severe graft-versus-host disease (GvHD) remains a major hurdle for successful allogeneic hematopoietic stem cell transplantation (HSCT). As the genetic dive
Autor:
Chao-Qun Wang, Chih-Hsin Tang, Yan Wang, Guinv Hu, Xiaoni Li, Bifei Huang, Chen-Ming Su, Qian Wang, Yongming Zhao, Lulu Jin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1 overexpression has been indicated in breast cancer patie
Autor:
Lars C Steggink, Jourik A. Gietema, Coby Meijer, Joop D. Lefrandt, Rudolf S N Fehrmann, Leon W.M.M. Terstappen, Hink Boer
Publikováno v:
The Pharmacogenomics Journal
Pharmacogenomics journal, 21. Nature Publishing Group
Pharmacogenomics Journal, 21(2), 152-164. Nature Publishing Group
Pharmacogenomics journal, 21. Nature Publishing Group
Pharmacogenomics Journal, 21(2), 152-164. Nature Publishing Group
Genetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ from known CVD-a
Autor:
My V. T. Phan, George Githinji, D. James Nokes, Paul Kellam, Patrick K. Munywoki, Graham F. Medley, Patricia A. Cane, Matthew Cotten, Charles N. Agoti
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, 9:10076. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, 9:10076. Nature Publishing Group
Infants (under 1-year-old) are at most risk of life threatening respiratory syncytial virus (RSV) disease. RSV epidemiological data alone has been insufficient in defining who acquires infection from whom (WAIFW) within households. We investigated RS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c4f378d3fe1bf19f33155b4a09da6b
http://hdl.handle.net/10044/1/71880
http://hdl.handle.net/10044/1/71880
Autor:
Rosalind A. Eeles, Karina Dalsgaard Sørensen, Torben F. Ørntoft, Jeri Kim, Wayne D. Tilley, Ruth C. Travis, Lorelei A. Mucci, Jenny L Donovan, Kay-Tee Khaw, Edward Giovannucci, Christopher I. Amos, Soo Hwang Teo, Claire Aukim-Hastie, Gerald L. Andriole, Linda Steele, Martin Eklund, Guomin Wang, Michael Borre, Antonio Finelli, Liesel M. FitzGerald, Thérèse Truong, Robert N. Hoover, Sandeep Singhal, Radka Kaneva, Frank Claessens, Robert Szulkin, Javier Llorca, Dominika Wokołorczyk, Esther M. John, Daniel J. Schaid, Jyotsna Batra, Kathryn L. Penney, Børge G. Nordestgaard, Catharine M L West, Hermann Brenner, Sue A. Ingles, Markus Aly, Jonathan Tyrer, Thomas J. Schnoeller, Xin Guo, Peter Iversen, Olivier Cussenot, Laurence N. Kolonel, Henrik Grönberg, Ninghan Feng, Geraldine Cancel-Tassin, Christiane Maier, David E. Neal, Marija Gamulin, Ezequiel Anokian, Christopher J. Logothetis, Shannon K. McDonnell, Lovise Maehle, Anssi Auvinen, Antonio Gómez-Caamaño, Tomislav Kuliš, Manuel Luedeke, Teuvo L.J. Tammela, Brian D. Carter, Zan Sun, Jong Y. Park, Nawaid Usmani, Ian M. Thompson, Zuxi Cui, Johanna Schleutker, Bernd Holleczek, Davor Lessel, Katarina Cuk, Eli Marie Grindedal, Milan S. Geybels, Yuan Chun Ding, Phyllis J. Goodman, Jing Ma, Paul A. Townsend, Edward J. Saunders, Melissa C. Southey, Graham G. Giles, Robert J. Hamilton, Laura Fachal, Mitchell J. Machiela, Demetrius Albanes, Gert De Meerleer, Paula Paulo, Agnieszka Michael, Yves Akoli Koudou, Janet L. Stanford, Kim De Ruyck, Thomas Van den Broeck, Tokhir Dadaev, Clara Cieza-Borrella, Sonja I. Berndt, Artitaya Lophatananon, Brian E. Henderson, Niclas Håkansson, Christopher A. Haiman, Florence Menegaux, Xueying Mao, Jan Lubinski, Elio Riboli, Paul D.P. Pharoah, David J. Hunter, Loic Le Marchand, Stephen N. Thibodeau, Fredrik Wiklund, Tobias Nordström, Thomas A. Sellers, Chee Goh, Elaine A. Ostrander, Sune F. Nielsen, Neil E. Fleshner, Neil G. Burnet, Rasmus Bisbjerg, Manuela Gago Dominguez, Csilla Sipeky, Maria Elena Martinez, Susan L. Neuhausen, Stephen J. Chanock, Hui Yi Lin, Laura E. Beane Freeman, A. Siddiq, Alicja Wolk, Gemma Castaño-Vinyals, Lisa F. Newcomb, Catherine M. Tangen, Ana Vega, Peter Kraft, Chavdar Slavov, Daniel Leongamornlert, Lisa A. Cannon-Albright, Stella Koutros, Manuel R. Teixeira, Susan M. Gapstur, Federico Canzian, Sara Lindström, Maren Weischer, Bettina F. Drake, Lisa G. Horvath, Daniel W. Lin, Jose Esteban Castelao, Yong-Jie Lu, Xin Sheng, Vanio Mitev, Ron H.N. van Schaik, Monique J. Roobol, Zsofia Kote-Jarai, Leire Moya, Alison M. Dunning, Mahbubl Ahmed, Kenneth Muir, Douglas F. Easton, Suzanne K. Chambers, Hongwei Zhang, Jianfeng Xu, Jasmine Lim, Meir J. Stampfer, Guido Jenster, Ali Amin Al Olama, Victoria L. Stevens, Sara Benlloch, Mark N. Brook, Azad Hassan Abdul Razack, Marta Cardoso, Matthew Parliament, Gail P. Risbridger, Samantha E.T. Larkin, Fredrick R. Schumacher, Martin Andreas Røder, Harry Ostrer, Judith A. Clements, Manolis Kogevinas, Barry S. Rosenstein, Steven Joniau, Richard M. Martin, Constance Turman, Mariana C. Stern, Joe Dennis, David V. Conti, Sarah L. Kerns, Adam S. Kibel, Robert J. MacInnis, Stephanie J. Weinstein, Freddie C. Hamdy, Cezary Cybulski, Nora Pashayan, Timothy J. Key, Hardev Pandha, Piet Ost
Publikováno v:
Schumacher, F R, Al Olama, A A, Berndt, S I, Benlloch, S, Ahmed, M, Saunders, E J, Dadaev, T, Leongamornlert, D, Anokian, E, Cieza-Borrella, C, Goh, C, Brook, M N, Sheng, X, Fachal, L, Dennis, J, Tyrer, J, Muir, K, Lophatananon, A, Stevens, V L, Gapstur, S M, Carter, B D, Tangen, C M, Goodman, P J, Thompson, I M, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Sorensen, K D, Orntoft, T F, Borre, M & Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8
the Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, 8, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8
Nature Genetics, 50(7), 928-+. Nature Publishing Group
the Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, 8, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8
Nature Genetics, 50(7), 928-+. Nature Publishing Group
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls
Publikováno v:
Scientific Reports
Rheumatoid arthritis (RA) is a common, chronic autoimmune disease affecting 0.5–1.0% of adults worldwide, including approximately 4.5–5.0 million patients in China. The genetic etiology and pathogenesis of RA have not yet been fully elucidated. R