Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Autor:
Lina-Marcela Diaz-Gallo, Tomoko Iseda, Lars Alfredsson, Susanna Kullberg, Camilla Bengtsson, Leonid Padyukov, Karina Patasova, Ingrid Kockum, Natalia V. Rivera, Johan Grunewald, Anders Eklund
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren’s
Autor:
Gene-Siew Ngian, Ali Bayoumi, Khaled Thabet, Lorenzo Beretta, Wendy Stevens, Nicholas Manolios, Kathleen Tymms, Susanna Proudman, Jane Zochling, Jacob George, Janet Roddy, Maureen Rischmueller, Mayada Metwally, Gemma Strickland, Susan C. Lester, Olfat G. Shaker, Pravin Hissaria, Mohammed Eslam, Mandana Nikpour, Christopher Liddle, Joanne Sahhar, Jennifer G Walker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-5 (2019)
Scientific Reports
Scientific Reports
Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene (IFNL3) was shown to be associated with fibrosis in liver across
Autor:
Sabine Matou-Nasri, Hamad I. Al-Ashgar, Jahad Alghamdi, Khalid Alswat, Ahmed A. Al-Qahtani, Waleed Al-Hamoudi, Arwa A. Al-Qahtani, Mashael R. Al-Anazi, Mohammed Q. Khan, Marie Fe F. Bohol, Monis Bilal Shamsi, Ayman A. Abdo, Mohammed N. Al-Ahdal, Salah K. Alanazi, Faisal M. Sanai, Ali Albenmousa, Damian M. Dela Cruz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Interleukin-37 (IL-37) has recently been recognized as a strong anti-inflammatory cytokine having anti-tumor activity against hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients. HCC is a typical inflammation-related cancer, a
Autor:
Teleri Clark, Sylviane Metairon, Patrick Descombes, Nele Gheldof, Joerg Hager, Victoria Shenton, Arne Astrup, Mary-Ellen Harper, Dominique Langin, Ondine Walter, Robert Dent, Hélène Ruffieux, G. Gregory Neely, Qiao-Ping Wang, Nathalie Viguerie, Wim H. M. Saris, Jérôme Carayol, Lisa J. Oyston, Paulina Lau, Gregory Lefebvre, Armand Valsesia, Polina Mironova, Christian Chabert
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications, 10:540, 1-10. Nature Publishing Group
Valsesia, A, Wang, Q-P, Gheldof, N, Carayol, J, Ruffieux, H, Clark, T, Shenton, V, Oyston, L J, Lefebvre, G, Metairon, S, Chabert, C, Walter, O, Mironova, P, Lau, P, Descombes, P, Viguerie, N, Langin, D, Harper, M-E, Astrup, A, Saris, W H, Dent, R, Neely, G G & Hager, J 2019, ' Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism ', Nature Communications, vol. 10, 540 . https://doi.org/10.1038/s41467-019-08492-8
Nature Communications
Nature Communications, 10:540, 1-10. Nature Publishing Group
Valsesia, A, Wang, Q-P, Gheldof, N, Carayol, J, Ruffieux, H, Clark, T, Shenton, V, Oyston, L J, Lefebvre, G, Metairon, S, Chabert, C, Walter, O, Mironova, P, Lau, P, Descombes, P, Viguerie, N, Langin, D, Harper, M-E, Astrup, A, Saris, W H, Dent, R, Neely, G G & Hager, J 2019, ' Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism ', Nature Communications, vol. 10, 540 . https://doi.org/10.1038/s41467-019-08492-8
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention re
Autor:
Eirini Maratou, Efthimios Pappas, Ioanna Kokkinopoulou, Maria-Ioanna Christodoulou, Christos K. Kontos, Eleni Boutati, Emmanuel G. Fragoulis, Panayota Mitrou, Andreas Scorilas, Margaritis Avgeris
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Despite significant progress by genome-wide association studies, the ability of genetic variants to conduce to the prediction or prognosis of type-2 diabetes (T2D) is weak. Expression analysis of the corresponding genes may suggest possible links bet
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports
Genetic Creutzfeldt-Jakob disease (gCJD) with E200K mutation is one of the common subtypes of human genetic prion diseases worldwide. In this study, we systematically analyzed 30 Chinese E200K gCJD cases for their epidemiological, clinical, laborator
Autor:
Ana Patiño-García, Borja Santos-Zorrozua, Africa Garcia-Orad, Angela Gutierrez-Camino, Idoia Martin-Guerrero, Nerea Bilbao-Aldaiturriaga, Vita Dolžan
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports
Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports
Association studies in osteosarcoma risk found significant results in intergenic regions, suggesting that regions which do not codify for proteins could play an important role. The deregulation of microRNAs (miRNAs) has been already associated with o
A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome
Autor:
Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Jamin, Christophe, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valérie, Boudjeniba, Cheïma, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodríguez-Pintó, Ignasi, De Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovács, László, Witte, Torsten, Bettacchioli, Eléonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Borghi, Maria Orietta, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickaël, Moingeon, Philippe, Alarcón-Riquelme, Marta, Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabel, Gonzalez-Gay Mantecón, Miguel Angel, Blanco Alonso, Ricardo, Corrales Martínez, Alfonso, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Aguirre-Zamorano, Ma Angeles, Escudero-Contreras, Alejandro, Castro-Villegas, Ma Carmen, Jiménez Gómez, Yolanda, Ortego, Norberto, Fernández Roldán, María Concepción, Raya, Enrique, Jiménez Moleón, Inmaculada, de Ramon, Enrique, Díaz Quintero, Isabel, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Zuber, Aleksandra, Wynar, Donatienne, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Hiepe, Falk, Thiel, Silvia, Rodriguez Maresca, Manuel, López-Berrio, Antonio, Aguilar-Quesada, Rocío, Navarro-Linares, Héctor, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcón Riquelme, Marta, Gomes Anjos, Tania, Marañón, Concepción, Le Lann, Lucas, Simon, Quentin, Rouvière, Bénédicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Gerl, Velia, Khodadadi, Laleh, Cheng, Qingyu, De Groof, Aurélie, Ducreux, Julie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Neves, Esmeralda, Rao, Sambasiva, Jouve, Pierre-Emmanuel
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5182e71983a3c820bc2eed151f2178
http://hdl.handle.net/10261/250682
http://hdl.handle.net/10261/250682
Autor:
Martin Farrall, William Watson, Heather J. Cordell, Kathryn A. McGurk, Oliver J Rider, Alistair Revell, Hugh Watkins, Bernard Keavney, Richard Nethononda, Benjamin Owen
Publikováno v:
McGurk, K, Owen, B, Watson, W, Nethononda, R, Cordell, H J, Farrall, M, Rider, O J, Watkins, H, Revell, A & Keavney, B 2020, ' Heritability of haemodynamics in the ascending aorta ', Scientific Reports, vol. 10, 14356 . https://doi.org/10.1038/s41598-020-71354-7
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Blood flow in the vasculature can be characterised by dimensionless numbers commonly used to define the level of instabilities in the flow, for example the Reynolds number, Re. Haemodynamics play a key role in cardiovascular disease (CVD) progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722c27e93a12f75f095e3f606bd42986
http://hdl.handle.net/10044/1/98546
http://hdl.handle.net/10044/1/98546
Autor:
Daniele Pastori, Anna Montali, Bruna De Masi, Alessia Di Costanzo, Marialuisa Sponziello, Diego Bailetti, Francesco Angelico, Laura D'Erasmo, Francesca Belardinilli, Licia Polimeni, Francesco Baratta, Giuseppe Giannini, Fabrizio Ceci, Gabriella Girelli, Antonio Angeloni, Maria Del Ben, Marcello Arca
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 gen