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Autor:
Mengyuan Niu, Li Li, Yibing Ding, Lulu Wei, Wangsen Cao, Wenyuan Pu, Zhonglan Su, Shiyu Song, Qian Gao, Hongwei Wang, Chen Zhao, Junaid Wazir
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly impairs the quality of life of cancer patients; however, the underlying pathological proc
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric s
Autor:
Silvia Guerrera, Melania Manco, Silvia Di Vara, Lucilla Ravà, Stefano Vicari, Marta Ciofi Degli Atti, Giovanni Valeri
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
The autism spectrum disorder (ASD) is an etiologically heterogeneous disorder. Dysfunctions of the intermediate metabolism have been described in some patients. We speculate these metabolic abnormalities are associated with brain insulin resistance (
Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo
Autor:
Markus J. Hofer, Samantha J. Lain, Velda X. Han, Natasha Nassar, Shekeeb S. Mohammad, Hannah F Jones, Russell C. Dale, Wendy A. Gold, Shrujna Patel, Timothy C Nielsen, Fabienne Brilot
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), trigge
Autor:
Kritika Subramanian, Selin Merdan, Turgay Ayer, Johan Van Weyenbergh, Jean L. Koff, Christopher R. Flowers, Andres Chang
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 1, Pp 1-12 (2021)
Blood Cancer Journal
Blood Cancer Journal
The clinical risk stratification of diffuse large B-cell lymphoma (DLBCL) relies on the International Prognostic Index (IPI) for the identification of high-risk disease. Recent studies suggest that the immune microenvironment plays a role in treatmen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.19066. ⟨10.1038/s41598-020-76011-7⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-76011-7⟩
Scientific Reports, Nature Publishing Group, 2020, 10, pp.19066. ⟨10.1101/751289⟩
Scientific Reports, 2020, 10 (1), pp.19066. ⟨10.1038/s41598-020-76011-7⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.19066. ⟨10.1038/s41598-020-76011-7⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-76011-7⟩
Scientific Reports, Nature Publishing Group, 2020, 10, pp.19066. ⟨10.1101/751289⟩
Scientific Reports, 2020, 10 (1), pp.19066. ⟨10.1038/s41598-020-76011-7⟩
The conditions used to describe the presence of an immune disease are often represented by interaction graphs. These informative, but intricate structures are susceptible to perturbations at different levels. The mode in which that perturbation occur
Autor:
Eun-Kyo Park, Jimin Kim, Yoosoo Chang, Seungho Ryu, Kyung Eun Yun, Han Na Kim, Hyung Lae Kim, Mi-Hyun Kim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Although obesity is associated with numerous diseases, the risks of disease may depend on metabolic health. Associations between the gut microbiota, obesity, and metabolic syndrome have been reported, but differences in microbiomes according to metab
Autor:
Evguenia Nepotchatykh, Dawei Li, Christian Godbout, Corinne Leveau, Alain Moreau, Viorica Lascau-Coman, Shawn Lauzon, Lynda Chalder, Yanick Maillet, Renata Kosovskaia, Emi Kanamaru, Catherine Beaudin, Wesam Elremaly, Saadallah Bouhanik, Yaned Patricia Gaitan, Anita Franco, Iurie Caraus
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
For years, avian influenza has influenced economies and human health around the world. The emergence and spread of avian influenza virus have been uncertain and sudden. The virus is likely to spread through several pathways such as poultry transporta