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Autor:
Tim S. Heistek, Sara Hijazi, Philip Scheltens, Derya R. Shimshek, August B. Smit, Ulf Neumann, Ronald E. van Kesteren, Huibert D. Mansvelder
Publikováno v:
Molecular Psychiatry, 25(12), 3380-3398. Nature Publishing Group
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibi
Autor:
Yan-Hong Li, Bin-Bin Fang, Xiao-Mei Li, Xiao-Ming Gao, Fen Liu, Jun-Yi Luo, Ting Tian, Yi-Ning Yang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Myocardial infarction (MI), the leading cause of mortality and disability worldwide, is a disease in which multiple environmental and genetic factors are involved. Recently, researches suggested that insertion/deletion (ins/del) variation of NFKB1 ge
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1). NATURE RESEARCH
Scientific Reports
Scientific Reports, 10(1)
Scientific Reports, 10(1). NATURE RESEARCH
Scientific Reports
Scientific Reports, 10(1)
Iron accumulation in the brain is a phenomenon common to many neurodegenerative diseases, perhaps most notably Alzheimer’s disease (AD).We present here magnetic analyses of post-mortem brain tissue of patients who had severe Alzheimer’s disease,
Autor:
Amin Marghalani, Wael Yaghmoor, Isabel Carreras, Jae-Yong Ahn, Christina M. Tognoni, Danielle Stephens, Alpaslan Dedeoglu, Alpdogan Kantarci
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Periodontal disease (PD) has been suggested to be a risk factor for Alzheimer’s disease (AD). We tested the impact of ligature-induced PD on 5xFAD mice and WT littermates. At baseline, 5xFAD mice presented significant alveolar bone loss compared to
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets ar
Autor:
Jinho Yang, Ju Kwang Choi, Yoon Jeong Park, Da Hyeon Choi, Jae Won Chang, Bon Seok Koo, Yoon Shin Park, Ho-Ryun Won, Won Hee Lee, Jiwon Park, Chan Oh, Ju Yeon Lee, Kyeong Eun Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1564-1573 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and re
Autor:
Maria Gavriatopoulou, Lia-Angela Moulopoulos, Evangelos Terpos, Nikolaos Kanellias, Andriani Βoultadaki, Efstathios Kastritis, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Magdalini Migkou, Charis Bourgioti, Despina Fotiou, Meletios A. Dimopoulos, Evangelos Eleutherakis-Papaiakovou, Vassilis Koutoulidis
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 9, Pp 1-7 (2020)
Blood Cancer Journal
Blood Cancer Journal
Introduction: Multiple myeloma (MM) is the second most common haematological malignancy and is characterized by bone marrow infiltration of monoclonal plasma cells and end-organ involvement. Smoldering MM (SMM) is an intermediate clinical entity betw
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
The akinetic/rigid (AR) motor subtype of Parkinson’s Disease is associated with increased rates of motor and cognitive decline. Cross-sectional studies examining the neural correlates of AR have found abnormalities in both subcortical and cortical
Autor:
Yaqian Xu, Ashley S. Harms, Anna S. Nordvig, Luigi Zecca, James E. Goldman, K. Ray Chaudhuri, Elena Moro, Valentina Leta, Alessandro Sette, Stanley Fahn, Osama Al-Dalahmah, Richard J. Smeyne, David Sulzer, Olimpia Meucci, Angelo Antonini, Luigi Bubacco
Publikováno v:
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-10 (2020)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s diseas
Autor:
Luigi Bonavina, Stefano Siboni, Veronica Lazzari, Daniele Bernardi, Emanuele Asti, Davide Ferrari
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
The magnetic sphincter augmentation (MSA) device has been proven safe and effective in controlling typical reflux symptoms and esophageal acid exposure for up to 6-year follow-up. Longer term outcomes have not been reported yet. A prospectively maint