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Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-3 (2017)
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-3 (2017)
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9d0d17403db4b93fc7988622565efb
Autor:
Liang-Hao Hu, Zhuan Liao, Fei Jiang, Jin-Huan Lin, Jun-Tao Ji, Ting-Ting Du, Zhao-Shen Li, Lei Xin, Dan Wang, Jun Gao
Publikováno v:
Scientific Reports
Chronic pancreatitis (CP) is an inflammatory disease characterized by progressive fibrosis of pancreas. Early diagnosis will improve the prognosis of patients. This study aimed to obtain serum miRNA biomarkers for early diagnosis of CP. In the curren
Publikováno v:
Scientific Reports
Alzheimer’s disease (AD) and ischemic brain injury are two major neurodegenerative diseases. Mitochondrial dysfunction commonly occurs in AD and ischemic brain injury. Currently, little attention has been paid to the glycans on mitochondrial glycop
Autor:
Salla Ruskamo, Erik I. Hallin, Guro Helén Vatne, Arne Raasakka, Päivi Joensuu, Ulrich Bergmann, Ilpo Vattulainen, Petri Kursula, Anne Baumann, Cecilie Katrin Kristiansen, Tuomo Nieminen
Publikováno v:
Scientific reports 7(1), 6510 (2017). doi:10.1038/s41598-017-06781-0
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
This article has an erratum: Doi 10.1038/s41598-017-18751-7 Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neuropathies. Recently, three CMT1-associated point mutations (I43N, T51P, and I52T) were discovered in the abundant per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50d966b1cc8f3805a8581f6ec05e126
https://bib-pubdb1.desy.de/record/398517
https://bib-pubdb1.desy.de/record/398517
Autor:
Christian Vogler, Matthias Fastenrath, Christian Beisel, David Coynel, Bernardo Delarue Bizzini, Thomas Elbert, Torsten Schwede, Angela Heck, Sarah Wilker, Philippe Demougin, Nathalie Schicktanz, Dominique J.-F. de Quervain, Thierry Sengstag, Annette Milnik, Iris-Tatjana Kolassa, Francina Hartmann, Jana Petrovska, Niko Beerenwinkel, Pablo Escobar, Tobias Egli, Eva Loos, Jochen Singer, Andreas Papassotiropoulos, Virginie Freytag, Vanja Vukojevic
Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b123aeba84f7aba57c969cbe1017fc27
Publikováno v:
Scientific Reports
Rydbirk, R, Folke, J, Winge, K, Aznar, S, Pakkenberg, B & Brudek, T 2016, ' Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases ', Scientific Reports, vol. 6, 37116 . https://doi.org/10.1038/srep37116
Rydbirk, R, Folke, J, Winge, K, Aznar, S, Pakkenberg, B & Brudek, T 2016, ' Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases ', Scientific Reports, vol. 6, 37116 . https://doi.org/10.1038/srep37116
Evaluation of gene expression levels by reverse transcription quantitative real-time PCR (RT-qPCR) has for many years been the favourite approach for discovering disease-associated alterations. Normalization of results to stably expressed reference g
Publikováno v:
Scientific Reports
In brains of Alzheimer’s disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production
Autor:
Marie E. Jetté, Kimberly A. Dill-McFarland, Alissa S. Hanshew, Susan L. Thibeault, Garret Suen
Publikováno v:
Scientific Reports
Prolonged diffuse laryngeal inflammation from smoking and/or reflux is commonly diagnosed as chronic laryngitis and treated empirically with expensive drugs that have not proven effective. Shifts in microbiota have been associated with many inflammat
Autor:
Zhi-Yao Xu, Bin Zhou, Zi-Ping Miao, Zhiping Chen, Zhang-Nv Yang, Ya-jing Li, Yisheng Sun, Hong-Jun Dong, Dan-Hong Qiu, Pingping Yao, Weifeng Liang, Zhi-yong Zhu, Hang-Jing Lu, Fang Xu, Wei-wei Wang, Hanping Zhu, Jie Qian, Yong Xia, Stijn van der Veen
Publikováno v:
Scientific Reports
Coxsackievirus A16 (CA16) is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD) in the Asia-pacific region. Although CA16 infections are generally mild, severe neurological manifestations or even death has been repo
Autor:
Werner J.H. Koopman, Luis Salamanca, Nico J. Diederich, P. Derkinderen, Laurent Antunes, Aidos Baumuratov, Laura Longhino, Marek Ostaszewski, Paul Antony, J Weber, Feng He
Publikováno v:
Scientific Reports, 6
Scientific reports, 6, 33117. England (2016).
Scientific Reports
Scientific reports, 6, 33117. England (2016).
Scientific Reports
Contains fulltext : 172471.pdf (Publisher’s version ) (Open Access) Based on autopsy material mitochondrial dysfunction has been proposed being part of the pathophysiological cascade of Parkinson's disease (PD). However, in living patients, evidenc