Zobrazeno 1 - 10
of 29
pro vyhledávání: ''
Autor:
Larry S. Barak, Richard A. Gibbs, Yushi Bai, Maria Kousi, Tanner O. Monroe, Karen Soldano, Jeremiah Savage, Sungjin Moon, Ramona M. Rodriguiz, Steven C. Brodar, Thomas Hansen, Melanie E. Garrett, Donna M. Muzny, Nicholas Katsanis, Akira Sawa, William C. Wetsel, Allison E. Ashley-Koch, Patrick F. Sullivan, Thomas Werge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in the postnatal brain. We show that ablation of pericentriolar material 1 in the mouse leads to progressive ciliary, anatomic
Autor:
Costantino Pitzalis, Esteban A. Gomez, Conrad Bessant, Romain A. Colas, Rebecca Hands, Myles Lewis, Patricia R. Souza, Jesmond Dalli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Autor:
Masaaki Toda, Taro Yasuma, Tetsu Kobayashi, Ahmed M. Abdel-Hamid, Osamu Hataji, Akira Mizoguchi, Kota Nishihama, Esteban C. Gabazza, Alvaro G. Hernandez, Hajime Fujimoto, Heejin Kim, Shujie Wang, Kentaro Fujiwara, Atsuro Takeshita, Tomohito Okano, Masayuki Fukumura, Yuko Okano, Peter M. Yau, Isaac Cann, Yoichi Nishii, Yasuhiro Kondoh, Junpei Ohtsuka, Yudong Ren, Jing Wu, Roderick I. Mackie, Valeria Fridman D’Alessandro, Christy L. Wright, Yutaka Yano, Christopher J. Fields, Hirokazu Kawagishi, Atsushi Tomaru, Kensuke Kataoka, Corina N. D’Alessandro-Gabazza, Gabriel V. Pereira, Tetsuya Nosaka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This intractable disease is associated with increased abundance of Staph
Autor:
Rima Kaddurah-Daouk, Kevin Huynh, Matthias Arnold, David A. Bennett, Siamak MahmoudianDehkordi, Lisa St John Williams, J. Will Thompson, Jon B. Toledo, Colette Blach, Jessica D. Tenenbaum, Rebecca Baillie, Barbara Brauner, Roberta Diaz Brinton, Andrew J. Saykin, Jan Krumsiek, Kwangsik Nho, Alexandra Kueider-Paisley, Leslie M. Shaw, Michael W. Weiner, Gabi Kastenmüller, Ralph N. Martins, P. Murali Doraiswamy, M. Arthur Moseley, Tyler Massaro, Peter J. Meikle, Eugenia Trushina, Xianlin Han, Rui Chang, Gregory Louie, John Q. Trojanowski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigat
Autor:
Corrado Priami, Melissa J. Morine, Valeria Savoca, Karla Misselbeck, Silvia Parolo, Pranami Bora, Maria Caterina Mione, Francesca Lorenzini, Enrico Domenici, Lorena Leonardelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Metabolic syndrome is a pathological condition characterized by obesity, hyperglycemia, hypertension, elevated levels of triglycerides and low levels of high-density lipoprotein cholesterol that increase cardiovascular disease risk and type 2 diabete
Autor:
Michael Kim, Mandeep Takhar, S. Neben, John R. Androsavich, Tania Valencia, Vishal Patel, Philip Bentley, Kara Kersjes, Scott Davis, Edmund C. Lee, Tiffany Chu, Randy Soriano, Jian Li, Sole Gatto, Kai Liu, Salma Sarwary, Andrea Flaten, Adam Pavlicek, Steven Lockton, Matanel Yheskel, Charles R. Allerson, Wright Timothy, Julia Kaplan, Graham Jang, Tate Owen, Annelie Schairer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease. Unfortunately, treatment options f
Autor:
Georgia Chenevix-Trench, Jan Pyman, David G. Hunstman, Hugo Saunders, Linda Mileshkin, Dane Cheasley, Alison Maree Hadley, Nadia Traficante, Clare L. Scott, Diane Provencher, Niko Thio, Clare G Fedele, Joy Hendley, Jason Li, Michael S. Anglesio, Prue E. Allan, Siobhan Hughes, Magnus Zethoven, Timothy Semple, Tom Jobling, Martin Köbel, Michael Christie, Goli Samimi, Kylie L. Gorringe, Anne Marie Mes-Masson, George Au-Yeung, Yoland Antill, Andrew N. Stephens, Cécile Le Page, Carolina Salazar, Kathryn Alsop, Anna deFazio, Kurosh Rahimi, Richard Lupat, Orla McNally, Georgina L Ryland, Jessica N. McAlpine, Ian G. Campbell, Renee Demeo, Rhiannon Dudley, Simone M Rowley, Michael Churchman, C. Blake Gilks, Gwo-Yaw Ho, Stephen B. Fox, Yoke Eng Chiew, Sally M Hunter, David D.L. Bowtell, Charlie Gourley, Catherine J. Kennedy, Zhongyue Xing, Scott H. Kaufmann, Nicole Fairweather, Kimberly R. Kalli, Alison Brand, Ragwha Sharma, Maret Böhm, Sian Fereday, Matthew Wakefield, Michelle C. Torres, Alice J. Sharpe, Neville F. Hacker, Sumitra Ananda, Kaushalya C. Amarasinghe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cheasley, D, J Wakefield, M, E Allan, P, L Ryland, G, Alsop, K, C Amarasinghe, K, Ananda, S, S Anglesio, M, Au-Yeung, G, Bohm, M, DL Bowtell, D, Brand, A, Chenevix-Trench, G, Christie, M, Chew, Y-E, Churchman, M, DeFazio, A, Demeo, R, Dudley, R, Fairweather, N, G Fedele, C, Fereday, S, B Fox, S, Gilks, C B, Gourley, C, F Hacker, N, M Hadley, A, Hendley, J, Ho, G-Y, Hughes, S, G Hunstman, D, M Hunter, S, W Jobling, T, R Kalli, K, H Kaufmann, S, J Kennedy, C, Kobel, M, Le Page, C, Li, J, Lupat, R, M McNally, O, N McAlpine, J, Mes-Masson, A-M, Mileshkin, L, M Provencher, D, Pyman, J, Rahimi, K, M Rowley, S, Salazar, C, Samimi, G, Saunders, H, Semple, T, Sharma, R, J Sharpe, A, N Stephens, A, Thio, N, C Torres, M, Traficante, N, Xing, Z, Zethoven, M, C Antill, Y, L Scott, C, G Campbell, I & Gorringe, K 2019, ' The Molecular Origin and Taxonomy of Mucinous Ovarian Carcinoma ', Nature Communications . https://doi.org/10.1038/s41467-019-11862-x
Nature Communications
Cheasley, D, J Wakefield, M, E Allan, P, L Ryland, G, Alsop, K, C Amarasinghe, K, Ananda, S, S Anglesio, M, Au-Yeung, G, Bohm, M, DL Bowtell, D, Brand, A, Chenevix-Trench, G, Christie, M, Chew, Y-E, Churchman, M, DeFazio, A, Demeo, R, Dudley, R, Fairweather, N, G Fedele, C, Fereday, S, B Fox, S, Gilks, C B, Gourley, C, F Hacker, N, M Hadley, A, Hendley, J, Ho, G-Y, Hughes, S, G Hunstman, D, M Hunter, S, W Jobling, T, R Kalli, K, H Kaufmann, S, J Kennedy, C, Kobel, M, Le Page, C, Li, J, Lupat, R, M McNally, O, N McAlpine, J, Mes-Masson, A-M, Mileshkin, L, M Provencher, D, Pyman, J, Rahimi, K, M Rowley, S, Salazar, C, Samimi, G, Saunders, H, Semple, T, Sharma, R, J Sharpe, A, N Stephens, A, Thio, N, C Torres, M, Traficante, N, Xing, Z, Zethoven, M, C Antill, Y, L Scott, C, G Campbell, I & Gorringe, K 2019, ' The Molecular Origin and Taxonomy of Mucinous Ovarian Carcinoma ', Nature Communications . https://doi.org/10.1038/s41467-019-11862-x
Nature Communications
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progressi
Autor:
Vishal Swaminathan, Prashant Chandrasekaran, Sowmya Jayachandran, Kiran Musunuru, David B. Frank, Apeksha Dave, Tiankun Wang, Brandon White, Heather A. Hartman, Sourav Bose, Rajan Jain, Haiying Li, Felix De Bie, Meghana V. Kashyap, Philip W. Zoltick, William H. Peranteau, Pallavi Menon, Kshitiz Singh, Shiva S. Teerdhala
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
In utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting multiple organs, often leading to early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6f3e77c2cfd338eb9e98b94b10a46a
https://doi.org/10.1038/s41467-021-24443-8
https://doi.org/10.1038/s41467-021-24443-8
Autor:
Marco A. Zarbin, Joan W. Miller, Michael B. Gorin, Marius Ueffing, Cynthia A. Toth, James T. Handa, Andrew D. Dick, Lindsay A. Farrer, Catherine Bowes Rickman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature communications, vol 10, iss 1
Handa, JT, Bowes Rickman, C, Dick, A, Gorin, M B, Miller, J W, Toth, C A, Ueffing, M, Zarbin, M & Farrer, L A 2019, ' A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration ', Nature Communications, vol. 10, no. 1, 3347 . https://doi.org/10.1038/s41467-019-11262-1
Nature Communications
Nature communications, vol 10, iss 1
Handa, JT, Bowes Rickman, C, Dick, A, Gorin, M B, Miller, J W, Toth, C A, Ueffing, M, Zarbin, M & Farrer, L A 2019, ' A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration ', Nature Communications, vol. 10, no. 1, 3347 . https://doi.org/10.1038/s41467-019-11262-1
Nature Communications
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “d