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Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Chunyu Zhang, Zhanying Wu, Feifei Yuan, Zhijuan Wang, Yanli Sun, Fengchao Wang, Yanying Cui, Meijia Zhang, Hongwei Wei, Ke-Ping Xie
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Sphingosine phosphate lyase 1 (SGPL1) is a highly conserved enzyme that irreversibly degrades sphingosine-1-phosphate (S1P). Sgpl1-knockout mice fail to develop germ cells, resulting in infertility. However, the molecular mechanism remains unclear. T
Autor:
Zheng Yu, Dongyan Ren, Bin Luo, Erkang Fei, Ziyang Liu, Baoming Li, Mingtao Xiong, Dong Lin, Changqin Zhao, Wenbing Chen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation. Cell adhesion molecules have been foun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Growing evidence indicates that circular RNAs (circRNAs) are closely involved in tumorigenesis, but the association between circRNAs and pancreatic ductal adenocarcinoma (PDAC) is far from clear. Here, we focused on the functional investigation of ci
Autor:
Zhenwei Xia, Zhihan Wang, Shugang Qin, Ping Lin, Pan Gao, Min Wu, Nadeem Khan, Colin K. Combs, Kai Guo, Qinqin Pu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-10 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Bitter receptors function primarily in sensing taste, but may also have other functions, such as detecting pathogenic organisms due to their agile response to foreign objects. The mouse taste receptor type-2 member 138 (TAS2R138) is a member of the G
Autor:
Kaili Long, Zhigang Guo, Yilan Zhang, Zhigang Hu, Lingfeng He, Enjie Li, Lulu Li, Feiyan Pan, Ziyu Zhang, Lili Gu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 is highly expressed and assoc
Autor:
Yan Zheng, Haoting Sun, Mo Chen, Yuan-Yuan Sheng, Lun-Xiu Qin, Qiongzhu Dong, Xudong Ren, Qin Luo, Bei-Yuan Hu, Yan Geng, Tiantian Zou, Xiao-Mei Gao, Kai-Li Zhang, Chaoqun Wang, Lu-Yu Yang, Shican Yan, Yan Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown. Exosomes released by tumor cells have been proved to be effective cell-to-cell signal m
Autor:
Christine Hartmann, Lena I. Wolff, Jessica Bertrand, Christine Fabritius, Stefan Teufel, Petra Köckemann, Thomas Pap
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Agonists and antagonists of the canonical Wnt signaling pathway are modulators of pathological aspects of rheumatoid arthritis (RA). Their activity is primarily modifying bone loss and bone formation, as shown in animal models of RA. More recently, m
Autor:
Wanning Zhang, Xuehui Wu, Yanqing Ding, Xiaoli Ren, Yongrong Yan, Li Liang, Zhicheng Zeng, Yumei He, Wangjun Liao, Feifei Wang, Wei Yang, Jianbiao Xiao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
In colorectal cancer (CRC), overt metastases often appear after years of latency. But the signals that cause micro-metastatic cells to remain indolent, thereby enabling them to survive for extended periods of time, are unclear. Immunofluorescence and
Autor:
Gaia Spinetti, Mario Tirone, Pasquale Creo, Simona Greco, Matteo Carrara, Paola Fuschi, Davide Maselli, Carlo Gaetano, Massimiliano Mazzone, Biagina Maimone, Fabio Martelli, Christine Voellenkle, Germana Zaccagnini, Marialucia Longo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that