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Autor:
Tim S. Heistek, Sara Hijazi, Philip Scheltens, Derya R. Shimshek, August B. Smit, Ulf Neumann, Ronald E. van Kesteren, Huibert D. Mansvelder
Publikováno v:
Molecular Psychiatry, 25(12), 3380-3398. Nature Publishing Group
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibi
Autor:
Amin Marghalani, Wael Yaghmoor, Isabel Carreras, Jae-Yong Ahn, Christina M. Tognoni, Danielle Stephens, Alpaslan Dedeoglu, Alpdogan Kantarci
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Periodontal disease (PD) has been suggested to be a risk factor for Alzheimer’s disease (AD). We tested the impact of ligature-induced PD on 5xFAD mice and WT littermates. At baseline, 5xFAD mice presented significant alveolar bone loss compared to
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets ar
Autor:
Masaaki Toda, Taro Yasuma, Tetsu Kobayashi, Ahmed M. Abdel-Hamid, Osamu Hataji, Akira Mizoguchi, Kota Nishihama, Esteban C. Gabazza, Alvaro G. Hernandez, Hajime Fujimoto, Heejin Kim, Shujie Wang, Kentaro Fujiwara, Atsuro Takeshita, Tomohito Okano, Masayuki Fukumura, Yuko Okano, Peter M. Yau, Isaac Cann, Yoichi Nishii, Yasuhiro Kondoh, Junpei Ohtsuka, Yudong Ren, Jing Wu, Roderick I. Mackie, Valeria Fridman D’Alessandro, Christy L. Wright, Yutaka Yano, Christopher J. Fields, Hirokazu Kawagishi, Atsushi Tomaru, Kensuke Kataoka, Corina N. D’Alessandro-Gabazza, Gabriel V. Pereira, Tetsuya Nosaka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This intractable disease is associated with increased abundance of Staph
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Physical exercise has been suggested to reduce the risk of developing Alzheimer’s disease (AD) as well as ameliorate the progression of the disease. However, we recently published results from two large epidemiological studies showing no such benef
Autor:
Andrew Parker, Sara Falcone, Charles D. Pusey, A Blease, Jeremy Sanderson, Laura Wisby, T Nicol, Paul Potter, Becky Starbuck, Steve D.M. Brown, Frederick W.K. Tam, Cheryl L. Scudamore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
The link between mutations in collagen genes and the development of Alport Syndrome has been clearly established and a number of animal models, including knock-out mouse lines, have been developed that mirror disease observed in patients. However, it
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently, there is no treatment for this detrimental disorder. Development of therapies
Autor:
Michael Kim, Mandeep Takhar, S. Neben, John R. Androsavich, Tania Valencia, Vishal Patel, Philip Bentley, Kara Kersjes, Scott Davis, Edmund C. Lee, Tiffany Chu, Randy Soriano, Jian Li, Sole Gatto, Kai Liu, Salma Sarwary, Andrea Flaten, Adam Pavlicek, Steven Lockton, Matanel Yheskel, Charles R. Allerson, Wright Timothy, Julia Kaplan, Graham Jang, Tate Owen, Annelie Schairer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease. Unfortunately, treatment options f
Autor:
Christoph Handschin, Marius Brazaitis, Tomas Venckunas, Igor Cervenka, Shamim Dadvar, Duarte M. S. Ferreira, Regula Furrer, Liu Zhengye, Lars Ketscher, Jorge L. Ruas, Johanna T. Lanner, Leandro Z. Agudelo, Manizheh Izadi, Sigitas Kamandulis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid.
Autor:
Justin J. Yerbury, Yossi Buskila, Michael Trpceski, Orsolya Kékesi, Tracey Berg, Wei Lin Seah, Lezanne Ooi, Alba Bellot-Saez
Publikováno v:
Cell Death and Disease, Vol 10, Iss 4, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Amyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND) in which humans lose motor functions due to progressive loss of motoneurons in the cortex, brainstem, and spinal cord. In patients and in animal models of MND it has been obs