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of 109
pro vyhledávání: ''
Autor:
Xiaofei Zheng, Shiwen Zhang, Guomin Ou, Peng Deng, Yunshu Wu, Cun-Yu Wang, Qiwen Li, Yuchen Guo, Y. Chen, Quan Yuan, Yuting Liu, Xingying Qi, Weiqing Liu, Yuan Wang, Liyan Zhou, Weimin Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in th
Autor:
Andrew P. Shoubridge, Jacob Thomas, Robert J. Adams, Mark van den Hurk, Adam Añonuevo, Erin Knock, Vivian Lee, Mark R. Hutchinson, Kasandra McCormack, Leon H. Chew, Bridget Milky, Carmen K. H. Mak, Anita Mahadevan-Jansen, Michael Zabolocki, Adam J. Hirst, Jenne Tran, Cedric Bardy, Philipp Reineck
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
The capabilities of imaging technologies, fluorescent sensors, and optogenetics tools for cell biology are advancing. In parallel, cellular reprogramming and organoid engineering are expanding the use of human neuronal models in vitro. This creates a
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Autor:
Jeffrey N. Savas, Vasily Rybakin, Nuno Apóstolo, Joris de Wit, Natalia V. Gounko, Samuel N. Smukowski, Jolijn ten Bos, Laura Trobiani, Davide Comoletti, Giuseppe Condomitti, Jeroen Vanderlinden, Sybren Portegies, Keimpe D. Wierda, Kristel M. Vennekens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications
Excitatory and inhibitory neurons are connected into microcircuits that generate circuit output. Central in the hippocampal CA3 microcircuit is the mossy fiber (MF) synapse, which provides powerful direct excitatory input and indirect feedforward inh
Autor:
Yamei Tang, Xinyi Chen, Leo Y. C. Yan, Ho Yin Edwin Chan, Hon-Cheong So, Lei Zhao, Wei-Jye Lin, Hei-Ming Lai, Zhongqi Li, Yu Huang, Xiao Yu Tian, Wai-Lung Ng, Samuel K. H. Sy, Joaquim S. L. Vong, Ho Ko, Junzhe Huang, Vincent Mok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive. Here, w
Autor:
Jimena Perez-Sanchez, Antoine G. Godin, Adalberto Merighi, Louis-Etienne Lorenzo, Yves De Koninck, Nicolas Doyon, Annie Castonguay, Samuel Ferland, Martin Cottet, Francesco Ferrini, Feng Wang, Isabel Plasencia-Fernandez, Chiara Salio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
GABAA/glycine-mediated neuronal inhibition critically depends on intracellular chloride (Cl−) concentration which is mainly regulated by the K+-Cl− co-transporter 2 (KCC2) in the adult central nervous system (CNS). KCC2 heterogeneity thus affects
Autor:
Kibaek Choe, Seon Pyo Hong, Intae Park, Dae-Sik Lim, Sang Heon Suh, Gou Young Koh, Myung Jin Yang, Hosung Bae, Ralf H. Adams, Hyunsoo Cho, Kari Alitalo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of heterogeneity within the villi stromal compartment and how IntSCs regulate the structure and function
Autor:
Minji Lee, Sanguk Kim, Eui-Cheol Shin, Hyobeen Choi, Eun Seo Park, Min-Seok Rha, You Jeong Lee, Dong Jin Joo, Dong-il Kwon, Seong Kyu Han, Yoon Ha Choi, Kwanghwan Lee, Eunmin Lee, Jong Kyoung Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are innate T cells that acquire memory phenotype in the thymus and share similar biological characteristics. However, how their effector differentiation is dev
Autor:
Michael W. Traxlmayr, Omer Dushek, Eva Maria Putz, Benjamin Salzer, Johannes B. Huppa, Elisabeth Lobner, Michelle C. Buri, Manfred Lehner, Boris Kovacic, Michael A. Schoeber, Wolfgang Holter, Timo Peters, Christian Obinger, Charlotte U. Zajc, Christina M. Schueller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
T cells engineered to express chimeric antigen receptors (CAR-T cells) have shown impressive clinical efficacy in the treatment of B cell malignancies. However, the development of CAR-T cell therapies for solid tumors is hampered by the lack of truly
Autor:
Hannah D. Coughlan, Helen Ierino, Timothy M. Johanson, Melissa J. Davis, Mark A. Dawson, Anna Gabrielyan, Charles C. Bell, Kira Behrens, Warren S. Alexander, Tracy A. Willson, Yih-Chih Chan, Stephen L. Nutt, Andrew J. Kueh, Sandra Mifsud, Elizabeth M. Viney, Michael Sze Yuan Low, Rhys S. Allan, Gordon K. Smyth, Marco J Herold, Thomas Boudier, Ladina DiRago, Kelly L. Rogers, David M Tarlinton, Rebecca Feltham, Omer Gilan, Ashley P. Ng, Craig D. Hyland, Soroor Hediyeh-Zadeh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via recombination