Zobrazeno 1 - 10
of 128
pro vyhledávání: ''
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Autor:
Ahasanul Hasan, Raquibul Hasan, Nusrat Subhan, Ferdous Khan, Mushfera Zamila, Ashraful Alam, Farzana Zerin, Mizanur Rahman, Shoumen Lasker, Faisal Parvez
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Diabetes is a leading cause of chronic kidney disease, and the high prevalence of sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further susceptible to SNS-mediated oxidative stress and accelerated kidney damage. Here,
Autor:
Jungwan Hong, Dongyeong Yoon, Youngpyo Nam, Tae Yong Lee, Kyoungho Suk, Kyung Suk Kim, Min Sung Kim, Sang Ryong Kim, Jong-Heon Kim, Ho-Won Lee, Pan-Woo Ko, Donggun Seo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Most cerebellar ataxias (CAs) are incurable neurological disorders, resulting in a lack of voluntary control by inflamed or damaged cerebellum. Although CA can be either directly or indirectly related to cerebellar inflammation, there is no suitable
Autor:
Ryan P. Badman, Jessica L. Killian, Michelle D. Wang, Fenghua Hu, Tuancheng Feng, Shanna Moore, Thomas A. Cleland
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Recent technological advances have introduced diverse engineered nanoparticles (ENPs) into our air, water, medicine, cosmetics, clothing, and food. However, the health and environmental effects of these increasingly common ENPs are still not well und
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Silicon dioxide nanoparticles (SiO2NPs) are widely applied in industry, chemical, and cosmetics. SiO2NPs is known to induce pulmonary toxicity. In this study, we investigated the molecular mechanisms of SiO2NPs on pulmonary toxicity using a lung alve
Autor:
Kampei Shimizu, Satoshi Shimo, Mieko Oka, Tomohiro Aoki, Kazuhiko Nozaki, Isao Ono, Nobuhiko Ohno, Hirokazu Koseki, Hirohiko Imai, Mika Kushamae, Haruka Miyata, Takakazu Kawamata, Yu Abekura, Akitsugu Kawashima
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Smooth muscle cells (SMCs) are the major type of cells constituting arterial walls and play a role to maintain stiffness via producing extracellular matrix. Here, the loss and degenerative changes of SMCs become the major histopathological features o
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
It has been suggested that miR-144 is pro-atherosclerotic via effects on reverse cholesterol transportation targeting the ATP binding cassette protein. This study used proteomic analysis to identify additional cardiovascular targets of miR-144, and s
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The purpose of this study was to determine if transient cell membrane disruptions (TPMDs) in single keratocytes can trigger signaling events in neighboring keratocytes. Stromal cells were cultured from human corneas (HCSC) and mouse corneas (MCSC). T
Autor:
Chaoliang Ge, He Qingxian, Zhang Pengfei, Haiping Hao, Pan Xiaojie, Hong Wang, Guo Yitong, Cui Shuang, Frank J. Gonzalez, Zhou Jiyu, Guangji Wang, Huang Ningning
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate and efficacies in clinical t
Autor:
Ling Zhang, Bin Tian, Mujeeb Ur Rehman, Mingshu Wang, Dekang Zhu, Xinxin Zhao, Ying Wu, Qihui Luo, Shun Chen, Ling Zhu, Ni Zeng, Yunya Liu, Mafeng Liu, Renyong Jia, Yanling Yu, Zhengli Chen, Qiao Yang, Juan Huang, Yin Wang, Anchun Cheng, Xiaoyue Chen, Yalan Lai, Leichang Pan, Shaqiu Zhang, Zhiwen Xu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Duck hepatitis A virus (DHAV) causes an infectious disease that mainly affects 1- to 4-week-old ducklings, resulting in considerable loss to the duck industry. Although there have been many studies on DHAV in recent years, the effects on host infecti