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Autor:
Shengnan Yang, Ziyang Hong, Qinglin Tan, Jinke Zhuge, Qiang Zuo, Xuxian Zhong, Jing Guo, Qiong Deng, Jiaqi Liao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding eff
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protect
Autor:
Zhigang Zhang, Zhihuang Zheng, Zhonghua Zhao, Huijuan Wu, Chuanlei Li, Jun Liu, Guangze Shao, Kexin Xu, Jinqing Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Acute kidney injury (AKI) is associated with significant morbidity and its chronic inflammation contributes to subsequent chronic kidney disease (CKD) development. Yes-associated protein (YAP), the major transcriptional coactivator of the Hippo pathw
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging evidence has demonstrated that alternative splicing has a vital role in regulating protein function, but how alternative splicing factors can be regulated remains unclear. We showed that the PPM1G, a protein phosphatase, regulated the phosph
Autor:
Jing Ji, Yue Li, Bin Liu, Xiaotian Huang, Mei Ji, Zhao Zhao, Wei Liu, Zhe Li, Kaige Wang, Penglin Xu, Jia Shi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a type of RNA binding protein that highly expressed in a variety of tumors and plays a vital role in tumor progression. However, its post-translational regulation through ubiquitin-mediated proteo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Neutrophils are significant compositions of solid tumors and exert distinct functions in different types of tumors. However, the precise role of neutrophils in the progression of breast cancer (BC) is presently unclear. In this study, by investigatin
Autor:
Shengyu He, Xiao Wang, Anqi He, Zihua Jiang, Keming Yu, Zedu Cui, Xuan Liu, Shuilian Chen, Xi Chen, Pei Chen, Jing Zhuang, Nandan Wu, Qian Luo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Exosomes derived from tumor cells play a key role in tumor development. In the present study, we identified the bioactivity of exosomes released from WERI-Rb1 retinoblastoma cells in tumor angiogenesis, as well as the underlying mechanism, through bi