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Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric s
Autor:
Eun-Kyo Park, Jimin Kim, Yoosoo Chang, Seungho Ryu, Kyung Eun Yun, Han Na Kim, Hyung Lae Kim, Mi-Hyun Kim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Although obesity is associated with numerous diseases, the risks of disease may depend on metabolic health. Associations between the gut microbiota, obesity, and metabolic syndrome have been reported, but differences in microbiomes according to metab
Autor:
Larry S. Barak, Richard A. Gibbs, Yushi Bai, Maria Kousi, Tanner O. Monroe, Karen Soldano, Jeremiah Savage, Sungjin Moon, Ramona M. Rodriguiz, Steven C. Brodar, Thomas Hansen, Melanie E. Garrett, Donna M. Muzny, Nicholas Katsanis, Akira Sawa, William C. Wetsel, Allison E. Ashley-Koch, Patrick F. Sullivan, Thomas Werge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in the postnatal brain. We show that ablation of pericentriolar material 1 in the mouse leads to progressive ciliary, anatomic
Autor:
Lydia Warburton, Tarek Meniawy, Elin S. Gray, Michelle R. Pereira, Ashleigh C. McEvoy, Leslie Calapre, Michael Millward, Mel Ziman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
BRAF inhibitors revolutionised the management of melanoma patients and although resistance occurs, there is a subgroup of patients who maintain durable disease control. For those cases with durable complete response (CR) it is not clear whether it is
Autor:
Eric J. Duell, Victor Moreno, Gemma Ibáñez-Sanz, Mireia Obón-Santacana, Robert Carreras-Torres
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
Several studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD
Autor:
Merete Eggesbø, Siddhartha Mandal, Anne Lise Brantsæter, Karl Mårild, German Tapia, Lars C. Stene, Nicolai A Lund-Blix, Ketil Størdal
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child
Autor:
Maria Gavriatopoulou, Lia-Angela Moulopoulos, Evangelos Terpos, Nikolaos Kanellias, Andriani Βoultadaki, Efstathios Kastritis, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Magdalini Migkou, Charis Bourgioti, Despina Fotiou, Meletios A. Dimopoulos, Evangelos Eleutherakis-Papaiakovou, Vassilis Koutoulidis
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 9, Pp 1-7 (2020)
Blood Cancer Journal
Blood Cancer Journal
Introduction: Multiple myeloma (MM) is the second most common haematological malignancy and is characterized by bone marrow infiltration of monoclonal plasma cells and end-organ involvement. Smoldering MM (SMM) is an intermediate clinical entity betw
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Autor:
Cecilie L. Bager, M. H. Tang, Anne-Christine Bay-Jensen, Søren Brunak, P. Frederiksen, Morten A. Karsdal, Joseph P.M. Blair
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Blair, J P M, Bay-Jensen, A-C, Tang, M H, Frederiksen, P, Bager, C, Karsdal, M & Brunak, S 2020, ' Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis ', Scientific Reports, vol. 10, no. 1, 13975 . https://doi.org/10.1038/s41598-020-70942-x
Scientific Reports
Blair, J P M, Bay-Jensen, A-C, Tang, M H, Frederiksen, P, Bager, C, Karsdal, M & Brunak, S 2020, ' Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis ', Scientific Reports, vol. 10, no. 1, 13975 . https://doi.org/10.1038/s41598-020-70942-x
Rheumatoid arthritis (RA) is a chronic inflammatory disease with fluctuating course of progression. Despite substantial improvement in treatments in recent years, treatment response is still not guaranteed. The aim of this study was to identify varia
Autor:
Juichi Fujimori, Tetsuya Akaishi, Masashi Aoki, Tadashi Ishii, Kazuo Fujihara, Michiaki Abe, Ichiro Nakashima, Tatsuro Misu, Toshiyuki Takahashi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
The progressive patterns of neurological disability in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) and the significance of clinical relapses to the progressions of neurological disability in these diseases have not bee