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Autor:
David C. Yeomans, Daniel I. Jacobs, Brendan J. Tunstall, Alexander Tzabazis, Dean S. Carson, Mary R. Lee, William H. Frey, Leah R. Hanson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain and various psychiatric disorders, however, there is scant evidence that oxytocin reaches the brain. We quantified the concentration and distribution patt
Autor:
Mengdan Xing, Zhe Li, Xiaojing Ye, Stephen R.J. Salton, Jin-lin Zou, Purva Bali, Yamei Tang, Wei-Jye Lin, Cheng Jiang, Noël A. Warren, Shuyu Zheng, Jingru Wu, Yan Zhao
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo mo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protect
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Receptor interaction protein kinase 1 (RIPK1) plays a diverse role in tumor necrosis factor α (TNFα) signalings. The ubiquitination of RIPK1 is essential for NF-κB activation, whereas its kinase activity promotes apoptosis and necroptosis. However
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
The balanced functionality of cellular proteostatic modules is central to both proteome stability and mitochondrial physiology; thus, the age-related decline of proteostasis also triggers mitochondrial dysfunction, which marks multiple degenerative d
Autor:
Ivana Rosenzweig, Goran Sedmak, Katarina Ilić, Kristina Mlinac-Jerković, Svjetlana Kalanj-Bognar
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiati
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Proper development of the mammalian cerebral cortex relies on precise gene expression regulation, which is controlled by genetic, epigenetic, and epitranscriptomic factors. Here we generate RNA demethylase Fto and methyltransferase Mettl3 cortical-sp
Autor:
Ya-Lin Wang, Qiong Liu, Yuanyuan Ma, Hao-ran Wu, Shanshan Zhang, Jin Yu, Honglei Xiao, Yaodong Zhang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
The purpose of the present study was to investigate whether catalpol exhibited neuroprotective effects in chronic unpredictable mild stress (CUMS) mice through oxidative stress-mediated nucleotide-binding oligomerization domain, leucine-rich repeat,
Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Zheng Yu, Dongyan Ren, Bin Luo, Erkang Fei, Ziyang Liu, Baoming Li, Mingtao Xiong, Dong Lin, Changqin Zhao, Wenbing Chen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation. Cell adhesion molecules have been foun