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Autor:
David C. Yeomans, Daniel I. Jacobs, Brendan J. Tunstall, Alexander Tzabazis, Dean S. Carson, Mary R. Lee, William H. Frey, Leah R. Hanson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain and various psychiatric disorders, however, there is scant evidence that oxytocin reaches the brain. We quantified the concentration and distribution patt
Autor:
Ya-Lin Wang, Qiong Liu, Yuanyuan Ma, Hao-ran Wu, Shanshan Zhang, Jin Yu, Honglei Xiao, Yaodong Zhang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
The purpose of the present study was to investigate whether catalpol exhibited neuroprotective effects in chronic unpredictable mild stress (CUMS) mice through oxidative stress-mediated nucleotide-binding oligomerization domain, leucine-rich repeat,
Autor:
Pablo Dolz-Gaitón, Gefei Chen, Hugo Balleza-Tapia, Jan Johansson, André Fisahn, Yuniesky Andrade-Talavera
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
Gamma and theta brain rhythms play important roles in cognition and their interaction can affect gamma oscillation features. Hippocampal theta oscillations depend on cholinergic and GABAergic input from the medial septum-diagonal band of Broca. These
Autor:
Jin-Kui Yang, Li Zhang, Youchun Wang, Fang-Yuan Yang, Wei Hou, Yingmei Feng, Changfa Fan, Wei-Li Yang, Rong-Hua Jin, Miao-Miao Zhao, Weijin Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SUMMARYTo discover new drugs to combat coronavirus disease 2019 (COVID-19), an understanding of the molecular basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is urgently needed. Here, for the first time, we report the
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat
Autor:
Mariah A.A. Meyer, Katsuhiko Nishimori, Max Anstötz, Lynn Y. Ren, Jelena Radulovic, Samantha Schroth, Ana Cicvaric, Viktoriya S. Grayson, Michael P. Fiske, Gianmaria Maccaferri, Anita L. Guedea
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry
Translational Psychiatry
In susceptible individuals, memories of stressful experiences can give rise to debilitating socio-affective symptoms. This occurs even when the ability to retrieve such memories is limited, as seen in patients suffering from traumatic amnesia. We the
Autor:
Kaiqi Kang, Jianguo Li, Zefeng Gao, Jingjing Jia, XianJun Liu, Chunyan Hao, Weiwei Guo, Zhijiang Rong
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Propionate has been reported to exert antidepressant effects, but high-dose propionate may induce autism-like symptoms in experimental animals through induction of dysbiosis of neurotransmitters. The bi-directional effects of propionate seem to be do
Autor:
João Mello-Vieira, Maria M. Mota, Vanessa Zuzarte-Luis, Tania F. de Koning-Ward, Francisco J. Enguita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
The habenula is a phylogenetically conserved epithalamic structure, which conveys negative information via inhibition of mesolimbic dopamine neurons. We have previously shown the expression of kisspeptin (Kiss1) in the habenula and its role in the mo
Autor:
Md. Shenuarin Bhuiyan, A. Wayne Orr, Xiuping Yu, Nicholas E. Goeders, Judy A. King, James G. Traylor, Paari Dominic, Brandon Hartman, Karen Y. Stokes, Connie L. Arnold, Sadia Nitu, Richa Aishwarya, Mohammad Alfrad Nobel Bhuiyan, Shafiul Alam, Mahboob Morshed, Manikandan Panchatcharam, Gopi K. Kolluru, Christopher G. Kevil, Sunitha Chandran, Matthew D. Woolard, Sumitra Miriyala, Chowdhury S. Abdullah, Naznin Sultana Remex
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-20 (2020)
Communications Biology
Communications Biology
Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy s