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Autor:
Tong Shen, Youlutuziayi Rixiati, Ling-Dong Cai, Jian-Ming Li, Jing-Lin Liu, Chu-Yi Wang, Yuan-Yuan Zhao, Shi Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-18 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The mechanisms and key factors involved in tumor environments for lung metastasis of CRC are still unclear. Here, using clinical samples from lung metastases of CRC patients, we found that intestinal immune network for IgA production was significantl
Autor:
Jiaming Su, Shu Zheng, Meng Lou, Yifei Shi, Qi Dong, Yajuan Rui, Dingbo Huang, Si Shen, Meng Wang, Na Zhao, Wenwen Zheng, Rongzhen Xu, Xiao-Fang Yu, Yong Cai, Shiqi Chen, Ying Hu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic, leading to millions of infections and hundreds of thousands of human deaths. The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human inna
Autor:
Jin-Kui Yang, Li Zhang, Youchun Wang, Fang-Yuan Yang, Wei Hou, Yingmei Feng, Changfa Fan, Wei-Li Yang, Rong-Hua Jin, Miao-Miao Zhao, Weijin Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SUMMARYTo discover new drugs to combat coronavirus disease 2019 (COVID-19), an understanding of the molecular basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is urgently needed. Here, for the first time, we report the
Autor:
Xin Wang, Wenqiang Liu, Dan Liao, Kuntai Jiang, Tiebang Kang, Ruhua Zhang, Jingjing Li, Zhiliang Cao, Miao Li, Sui Jianhua, Cuiling Zeng, Yi Xin Zeng, Jingxuan Wang, Li Zhong
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-16 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PY
Autor:
Yanping Yu, Xiaofang Zhang, Jun Liu, Xinhui Zhao, Ye Wu, Haiming Liu, Jipeng Li, Jianyong Sun, Yihuan Qiao, Angang Yang, Ke Wang, Rui Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in cancer development and progression. However, the general regulatory mechanism of FoxM1 is still limited. STMN1 is a microtubule-binding protein which can inhib
Autor:
Hong Yang, Jing Xu, Jinhai Tang, Qing Li, Runqiu Jiang, Xuehao Wang, Liyong Pu, Jiannan Qiu, Yong Ni, Yuanchang Hu, Liren Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possibl
Autor:
Zengwu Shao, Bo Zhou, Ge Zhang, Qinnan Yan, Youqiang Song, Xiaohao Wu, Lei Qin, Wenfei Jin, Di Chen, Sheng Chen, Meiqing Wang, Huiling Cao, Xuekun Fu, Yumei Lai, Chu Tao, Sixiong Lin, Guozhi Xiao, Xuenong Zou
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-13 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells usi
Autor:
Michael Nilsson, Lin Kooi Ong, Murielle G. Kluge, Wei Zhen Chow, Frederick R. Walker, Prajwal Gyawali
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
For many chronic stroke survivors, persisting cognitive dysfunction leads to significantly reduced quality of life. Translation of promising therapeutic strategies aimed at improving cognitive function is hampered by existing, disparate cognitive ass
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-77026-w⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-77026-w⟩
The vestibulo-ocular reflex (VOR) and the optokinetic reflex (OKR) work synergistically to stabilize gaze in response to head movements. We previously demonstrated that a 14-day visuo-vestibular mismatch (VVM) protocol applied in freely behaving mice
Autor:
Anthony J. Ricci, Z Jason Qian
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Current clinical interest lies in the relationship between hearing loss and cognitive impairment. Previous work demonstrated that noise exposure, a common cause of sensorineural hearing loss (SNHL), leads to cognitive impairments in mice. However, in