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Autor:
Mengyuan Niu, Li Li, Yibing Ding, Lulu Wei, Wangsen Cao, Wenyuan Pu, Zhonglan Su, Shiyu Song, Qian Gao, Hongwei Wang, Chen Zhao, Junaid Wazir
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly impairs the quality of life of cancer patients; however, the underlying pathological proc
Autor:
Christine Hartmann, Lena I. Wolff, Jessica Bertrand, Christine Fabritius, Stefan Teufel, Petra Köckemann, Thomas Pap
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Agonists and antagonists of the canonical Wnt signaling pathway are modulators of pathological aspects of rheumatoid arthritis (RA). Their activity is primarily modifying bone loss and bone formation, as shown in animal models of RA. More recently, m
Autor:
Eirini P. Papapetrou, Oliver Soehnlein, Andriana G. Kotini, Ying Wei, Ross L. Levine, David G. Thomas, Marit Westerterp, Joachim Pircher, Hans-Willem Snoeck, Steffen Massberg, Alan R. Tall, Larry Luchsinger, Nan Wang, Chenyi Xue, Carlos Silvestre-Roig, Tong Xiao, M. Yalcinkaya, Trevor P. Fidler, Peter Libby, Christian Schulz, Mohammad Ali Hajebrahimi, Brian Hardaway, Wenli Liu, Muredach P. Reilly, Benjamin L. Ebert, Sandra Abramowicz
Publikováno v:
The journal of cardiovascular aging
Nature, 592(7853), 296-301. Nature Publishing Group
Nature
Nature, 592(7853), 296-301. Nature Publishing Group
Nature
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independen
Autor:
Siwen Zhao, Jingmei Li, Xingli Qian, Haixuan Wang, Wenhai Yu, Xiaozhong Peng, Dexuan Kuang, Bin Yin, Longjiang Xu, Kaiyun Ding, Jiahong Gao, Junbin Wang, Haiting Long, Li Jiao, Shuaiyao Lu, Haiyan Li, Jingwen Xu, Mengli Yang, Fangyu Luo, Yun Yang, Wei Liu, Hongqi Liu, Jing Yang, Yuan Zhao, Chunxia Ma
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of C
Autor:
Shuang Hui, Meng Ni, Yongxia Dang, Yating Yang, Menglan Niu, Zijie Zhang, Yuanyuan Wu, Yang Wang, Jiaxin Wang, Dengke Bao, Lixin Wan, Bo Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
TEFM (transcription elongation factor of mitochondria) has been identified as a novel nuclear-encoded transcription elongation factor in the transcription of mitochondrial genome. Our bioinformatics analysis of TCGA data revealed an aberrant over-exp
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Ischemia–reperfusion injury (IRI)-induced acute kidney injury (AKI) is a life-threatening disease. The activation of mitophagy was previously identified to play an important role in IRI. Maternally expressed 3 (MEG3) can promote cerebral IRI and he
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Amifostine has been the only small molecule radio-protector approved by FDA for decades; however, the serious adverse effects limit its clinical use. To address the toxicity issues and maintain the good potency, a series of modified small polycystein
Autor:
Zhixia Chen, Xibing Ding, Quan Li, Mengzhu Li, Renlingzi Zhang, Lingling Zhang, Xiaoyin Niu, Zhuang Yu, Bruce R. Pitt, Yao Tong, Timothy R. Billiar, Xiaohu Yang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Imbalance of macrophage polarization plays an indispensable role in acute lung injury (ALI), which is considered as a promising target. Matrix metalloproteinase-9 (MMP-9) is expressed in the macrophage, and has a pivotal role in secreting inflammator
Autor:
Tim S. Heistek, Sara Hijazi, Philip Scheltens, Derya R. Shimshek, August B. Smit, Ulf Neumann, Ronald E. van Kesteren, Huibert D. Mansvelder
Publikováno v:
Molecular Psychiatry, 25(12), 3380-3398. Nature Publishing Group
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Molecular Psychiatry
Hijazi, S, Heistek, T S, Scheltens, P, Neumann, U, Shimshek, D R, Mansvelder, H D, Smit, A B & van Kesteren, R E 2020, ' Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease ', Molecular Psychiatry, vol. 25, no. 12, pp. 3380-3398 . https://doi.org/10.1038/s41380-019-0483-4
Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibi