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Autor:
Shengnan Yang, Ziyang Hong, Qinglin Tan, Jinke Zhuge, Qiang Zuo, Xuxian Zhong, Jing Guo, Qiong Deng, Jiaqi Liao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding eff
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological
Autor:
Weijun Liu, Weiyang Cai, Ying-Li Wu, Wenfu Tan, Jun Yang, Yu Zou, Yuan Liu, Qingqing Ding, Wenjing Huang, Yu Zhang, Juan Wang, Jing Gao, Hu Zhou, Zhang Yanjie, Pei hao Yin, Yanyan Qiu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Chemotherapy remains the primary treatment of advanced solid cancer, including lung cancer. However, as first-line treatment, cisplatin-based therapy is restricted by the frequent development of drug resistance. Increasing data showed that the progra
Autor:
Junjie Xu, Liye Tao, Zhongjie Lin, Shunjie Xia, Yifan Wang, Xiao Liang, Liuxin Cai, Zhe Wan, Junhao Zheng, Xiujun Cai, Lin Ji, Yeling Ruan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. The first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Cell Death & Disease
Cell Death & Disease
The decrease of neurotransmitter dopamine (DA) levels in the intestine is closely related to the development of inflammatory bowel disease (IBD). However, the functional relevance and underlying mechanistic basis of the effects of DA signaling on IBD
Autor:
Jin-Kui Yang, Li Zhang, Youchun Wang, Fang-Yuan Yang, Wei Hou, Yingmei Feng, Changfa Fan, Wei-Li Yang, Rong-Hua Jin, Miao-Miao Zhao, Weijin Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SUMMARYTo discover new drugs to combat coronavirus disease 2019 (COVID-19), an understanding of the molecular basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is urgently needed. Here, for the first time, we report the
Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo
Autor:
Shuxia Yao, Zhongbo Zhao, Christian Montag, Qianqian Wang, Juan Kou, Yingying Zhang, Benjamin Becker, Chunmei Lan, Keith M. Kendrick, Feng Zhou
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed as a potential therapeutic intervention in psychiatric disorders. However, following intranasal administration, oxytocin could penetrate directly into the brai
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat